Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Richard S, Lee"'
Autor:
Olivia H. Cox, Fayaz Seifuddin, Jeffrey Guo, Mehdi Pirooznia, Gretha J. Boersma, Josh Wang, Kellie L.K. Tamashiro, Richard S. Lee
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
Epigenomic annotations for the rat lag far behind those of human and mouse, despite the rat’s immense utility in pharmacological and behavioral studies and the need to understand their epigenetic mechanisms. We have designed a targeted-enrichment m
Externí odkaz:
https://doaj.org/article/04eae527e9f24a36a4966ade55db0208
Blood DNA methylation of CRF and its association with amygdala volume and mood in Cushing’s syndrome
Autor:
Richard S. Lee, Alicia Santos, Henri Garrison-Desany, Anna Aulinas, Jenny L. Carey, Yolanda Vives-Gilabert, Olivia H. Cox, Gabriel Cuilan, Susan M. Webb, Eugenia Resmini
Publikováno v:
Frontiers in Epigenetics and Epigenomics, Vol 2 (2024)
ObjectiveThe impact of chronic exposure to stress or glucocorticoids on psychiatric symptoms has been exemplified by cases of iatrogenic or endogenous hypercortisolism such as Cushing’s syndrome (CS). The amygdala plays an important role in mediati
Externí odkaz:
https://doaj.org/article/30bb08d01b2241c28b13c953263eb5c8
Autor:
Chen-Han Wilfred Wu, Tze Y. Lim, Chunyan Wang, Steve Seltzsam, Bixia Zheng, Luca Schierbaum, Sophia Schneider, Nina Mann, Dervla M. Connaughton, Makiko Nakayama, Amelie T. van der Ven, Rufeng Dai, Caroline M. Kolvenbach, Franziska Kause, Isabel Ottlewski, Natasa Stajic, Neveen A. Soliman, Jameela A. Kari, Sherif El Desoky, Hanan M. Fathy, Danko Milosevic, Daniel Turudic, Muna Al Saffar, Hazem S. Awad, Loai A. Eid, Aravind Ramanathan, Prabha Senguttuvan, Shrikant M. Mane, Richard S. Lee, Stuart B. Bauer, Weining Lu, Alina C. Hilger, Velibor Tasic, Shirlee Shril, Simone Sanna-Cherchi, Friedhelm Hildebrandt
Publikováno v:
European Urology Open Science, Vol 44, Iss , Pp 106-112 (2022)
Background: Congenital anomalies of the kidneys and urinary tract (CAKUT) are the most common cause of chronic kidney disease among children and adults younger than 30 yr. In our previous study, whole-exome sequencing (WES) identified a known monogen
Externí odkaz:
https://doaj.org/article/3efb0bd1ab7841249ffc6b6938766552
Autor:
Olivia H. Cox, Ha Young Song, Henri M. Garrison-Desany, Nuriya Gadiwalla, Jenny L. Carey, Julia Menzies, Richard S. Lee
Publikováno v:
Epigenetics, Vol 16, Iss 12, Pp 1377-1397 (2021)
Exposure to stress or glucocorticoids (GCs) is associated with epigenetic and transcriptional changes in genes that either mediate or are targets of GC signalling. FKBP5 (FK506 binding protein 5) is one such gene that also plays a central role in neg
Externí odkaz:
https://doaj.org/article/755fd032d7554311afd95f85fa951be1
Autor:
Andre K. Portella, Afroditi Papantoni, Antoneta T. Joseph, Liuyi Chen, Richard S. Lee, Patricia P. Silveira, Laurette Dube, Susan Carnell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The dopamine receptor 4 (DRD4) in the prefrontal cortex (PFC) acts to modulate behaviours including cognitive control and motivation, and has been implicated in behavioral inhibition and responsivity to food cues. Adolescence is a sensitive
Externí odkaz:
https://doaj.org/article/aeea860e9e8d4dc5b769e81dd07e31b1
Autor:
Laramie D Lemon, Sneha Kannan, Kim Wai Mo, Miranda Adams, Haley G Choi, Alexander O D Gulka, Elise S Withers, Hasset T Nurelegne, Valeria Gomez, Reina E Ambrocio, Rhea Tumminkatti, Richard S Lee, Morris Wan, Milo B Fasken, Jennifer M Spangle, Anita H Corbett
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 7 (2022)
AbstractSomatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single his
Externí odkaz:
https://doaj.org/article/4d79f600263649b8878492dc6f2abbc7
Autor:
Hsin-Hsiao S Wang, Patricia S Cho, Hui Zhi, Stephen A Kostel, Shannon DiMartino, Adelle M Dagher, Kylie H Davis, Lily D Cabour, Ashley Shimmel, James Lee, John W Froehlich, David Zurakowski, Marsha A Moses, Richard S Lee
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0270018 (2022)
ImportanceExtracellular matrix proteins and enzymes involved in degradation have been found to be associated with tissue fibrosis and ureteropelvic junction obstruction (UPJO). In this study we developed a promising urinary biomarker model which can
Externí odkaz:
https://doaj.org/article/f286ae9dddac4478aa644b6b605b10ec
Autor:
Zachary A. Cordner, Isaiah Marshall-Thomas, Gretha J. Boersma, Richard S. Lee, James B. Potash, Kellie L.K. Tamashiro
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100392- (2021)
The adverse effects of stress on brain and behavior have long been known and well-studied, with abundant evidence linking stress to, among other things, mood and anxiety disorders. Likewise, many have investigated potential treatments for stress-rela
Externí odkaz:
https://doaj.org/article/a3b8625a03fc42d7a03b1b549afa54c6
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/73aa8a0c0fd04cc09afe80e4fe913382
Autor:
Andre Krumel Portella, Afroditi Papantoni, Catherine Paquet, Spencer Moore, Keri Shiels Rosch, Stewart Mostofsky, Richard S Lee, Kimberly R Smith, Robert Levitan, Patricia Pelufo Silveira, Susan Carnell, Laurette Dube
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234601 (2020)
Body weight is substantially determined by eating behaviors, which are themselves driven by biological factors interacting with the environment. Previous studies in young children suggest that genetic influences on dopamine function may confer differ
Externí odkaz:
https://doaj.org/article/760f0bdc98c4416aaa398b44fcf5f6d9