Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Richard R. Goodwin"'
Autor:
Ronald Palin, Hardy Sundaram, Philip S. Jones, David Vrolijk, Louise Evans, Mark A. Weston, David R. Barn, Grove Simon James Anthony, Helen Feilden, John K. Clark, J. Cottney, Marc Crockatt, Alasdair R.C. Smith, Grant Wishart, Paul Wren, Phillip M. Cowley, Richard Morphy, Frank Griekspoor, Richard R. Goodwin, Andrea K. Houghton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:589-593
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43590a4562dd3711ecd7e4e22da1580f
https://doi.org/10.1016/j.bmcl.2004.11.049
https://doi.org/10.1016/j.bmcl.2004.11.049
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Autor:
Geddis A; EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K.; Centre for Inflammation Research, The University of Edinburgh, Edinburgh EH16 4UU, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, U.K., Mendive-Tapia L; Centre for Inflammation Research, The University of Edinburgh, Edinburgh EH16 4UU, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, U.K., Sujantho A; EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K.; Centre for Inflammation Research, The University of Edinburgh, Edinburgh EH16 4UU, U.K., Liu E; EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K.; Centre for Inflammation Research, The University of Edinburgh, Edinburgh EH16 4UU, U.K., McAughtrie S; EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K., Goodwin R; Clinical Pharmacology and Safety Sciences, Biopharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Vendrell M; Centre for Inflammation Research, The University of Edinburgh, Edinburgh EH16 4UU, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, U.K., Campbell CJ; EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh EH9 3FJ, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, U.K.
Publikováno v:
Analytical chemistry [Anal Chem] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.
Autor:
Morgan HJ; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Olivero C; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Shorning BY; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Gibbs A; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Phillips AL; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Ananthan L; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Lim AXH; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Martuscelli L; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy., Borgogna C; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy., De Andrea M; Viral Pathogenesis Unit, Department of Public Health and Pediatric Sciences, University of Turin Medical School, Turin, Italy.; Intrinsic Immunity Unit, Translational Research Centre for Autoimmune and Allergic Diseases, University of Eastern Piedmont, Novara, Italy., Hufbauer M; Institute of Virology, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany., Goodwin R; Department of Dermatology, Aneurin Bevan University Health Board, Royal Gwent Hospital, Newport, United Kingdom., Akgül B; Institute of Virology, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany., Gariglio M; Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy., Patel GK; European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, United Kingdom.
Publikováno v:
JCI insight [JCI Insight] 2024 Jun 25; Vol. 9 (15). Date of Electronic Publication: 2024 Jun 25.
Autor:
Pearce SM; Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK., Cross NA; Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK., Smith DP; Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK., Clench MR; Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK., Flint LE; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, The Discovery Centre (DISC), Biomedical Campus, 1 Francis Crick Ave, Trumpington, Cambridge CB2 0AA, UK., Hamm G; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, The Discovery Centre (DISC), Biomedical Campus, 1 Francis Crick Ave, Trumpington, Cambridge CB2 0AA, UK., Goodwin R; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, The Discovery Centre (DISC), Biomedical Campus, 1 Francis Crick Ave, Trumpington, Cambridge CB2 0AA, UK., Langridge JI; Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, Cheshire SK9 4AX, UK., Claude E; Waters Corporation, Stamford Avenue, Altrincham Road, Wilmslow, Cheshire SK9 4AX, UK., Cole LM; Centre for Mass Spectrometry Imaging, Biomolecular Sciences Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK.
Publikováno v:
Metabolites [Metabolites] 2024 May 29; Vol. 14 (6). Date of Electronic Publication: 2024 May 29.
Autor:
Jain V; All Wales Medical Genomics Service, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK. vani.jain@wales.nhs.uk., Foo SH; Department of Dermatology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B4 6NH, UK.; Department of Dermatology, Gleneagles Hospital Medini, Nusajaya, 79250, Johor, Malaysia., Chooi S; School of Medicine, Cardiff University, Heath Park Campus, Cardiff, CF14 4YS, UK., Moss C; Department of Dermatology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, B4 6NH, UK.; University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Goodwin R; Department of Dermatology, Royal Gwent Hospital, Newport, NP20 2UB, UK., Berland S; Department of Medical Genetics, Haukeland University Hospital, 5021, Bergen, Norway., Clarke AJ; All Wales Medical Genomics Service, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.; Division of Cancer and Genetics, Cardiff University, Cardiff, CF14 4XN, UK., Davies SJ; All Wales Medical Genomics Service, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK., Corrin S; All Wales Medical Genomics Service, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK., Murch O; All Wales Medical Genomics Service, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK., Doyle S; Department of Medical Genetics, Our Lady's Children's Hospital, Crumlin, Dublin, D12 N512, Ireland.; Department of Clinical Genetics, The National Maternity Hospital, Holles Street, Dublin, D02 YH21, Ireland., Graham GE; Department of Genetics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada., Greenhalgh L; Liverpool Centre for Genomic Medicine, Liverpool Women's Hospital, Liverpool, L8 7SS, UK., Holder SE; North West Thames Regional Genetic Service, Kennedy Galton Centre, Northwick Park Hospital, Harrow, HA1 3UJ, UK., Johnson D; Department of Clinical Genetics, Northern General Hospital, Sheffield, S5 7AU, UK., Kumar A; North East Thames Regional Genetics Service, Great Ormond Street Hospital, London, WC1N 3JH, UK., Ladda RL; Department of Pediatrics, Division of Human Genetics, Penn State Health Children's Hospital, Hershey, Pennsylvania, 17033, USA., Sell S; Department of Pediatrics, Division of Human Genetics, Penn State Health Children's Hospital, Hershey, Pennsylvania, 17033, USA., Begtrup A; GeneDx, Gaithersburg, Maryland, 20877, USA., Lynch SA; Department of Medical Genetics, Our Lady's Children's Hospital, Crumlin, Dublin, D12 N512, Ireland., McCann E; Liverpool Centre for Genomic Medicine, Liverpool Women's Hospital, Liverpool, L8 7SS, UK., Østern R; Department of Medical Genetics, St. Olavs Hospital, Trondheim University Hospital, 7030, Trondheim, Norway., Pottinger C; All Wales Medical Genomics Service, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK., Splitt M; Northern Genetics Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE1 3BZ, UK., Fry AE; All Wales Medical Genomics Service, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK. fryae@cardiff.ac.uk.; Division of Cancer and Genetics, Cardiff University, Cardiff, CF14 4XN, UK. fryae@cardiff.ac.uk.
Publikováno v:
European journal of human genetics : EJHG [Eur J Hum Genet] 2023 Dec; Vol. 31 (12), pp. 1421-1429. Date of Electronic Publication: 2023 Sep 14.
Autor:
Graziano V; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK vincenzo.graziano@astrazeneca.com Duncan.Jodrell@cruk.cam.ac.uk.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK., Dannhorn A; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences (CPSS), AstraZeneca R&D, Cambridge, UK., Hulme H; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences (CPSS), AstraZeneca R&D, Cambridge, UK., Williamson K; Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK., Buckley H; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Karim SA; Cancer Research UK Beatson Institute, Glasgow, UK., Wilson M; Oncology R&D, Research and Early Development, AstraZeneca R&D, Cambridge, UK., Lee SY; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Kaistha BP; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Islam S; Department of Oncology, University of Cambridge, Cambridge, UK., Thaventhiran JED; Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK., Richards FM; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Goodwin R; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences (CPSS), AstraZeneca R&D, Cambridge, UK., Brais R; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Morton JP; Cancer Research UK Beatson Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Dovedi SJ; Oncology R&D, Research and Early Development, AstraZeneca R&D, Cambridge, UK., Schuller AG; Oncology, AstraZeneca R&D Boston, Waltham, Massachusetts, USA., Eyles J; Oncology R&D, Research and Early Development, AstraZeneca R&D, Cambridge, UK., Jodrell DI; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK vincenzo.graziano@astrazeneca.com Duncan.Jodrell@cruk.cam.ac.uk.; Department of Oncology, University of Cambridge, Cambridge, UK.
Publikováno v:
Journal for immunotherapy of cancer [J Immunother Cancer] 2023 Aug; Vol. 11 (8).
Autor:
Waugh ML; Biomedical Engineering Program, University of South Carolina, Columbia, SC, United States., Boltin N; Biomedical Engineering Program, University of South Carolina, Columbia, SC, United States., Wolf L; Biomedical Engineering Program, University of South Carolina, Columbia, SC, United States., Goodwin J; Biomedical Sciences, University of South Carolina School of Medicine - Greenville, Greenville, SC, United States., Parker P; Prisma Health Greenville, Greenville, SC, United States., Horner R; Department of Health Services Research and Administration, University of Nebraska Medical Center, Omaha, NE, United States., Hermes M; Department of Bioengineering, Clemson University, Clemson, SC, United States., Wheeler T; Spartanburg Regional Healthcare System, Spartanburg, SC, United States., Goodwin R; Biomedical Sciences, University of South Carolina School of Medicine - Greenville, Greenville, SC, United States., Moss M; Biomedical Engineering Program, University of South Carolina, Columbia, SC, United States.; Department of Chemical Engineering, University of South Carolina, Columbia, SC, United States.
Publikováno v:
JMIR perioperative medicine [JMIR Perioper Med] 2023 May 31; Vol. 6, pp. e40402. Date of Electronic Publication: 2023 May 31.
Autor:
Hamedi KR; School of Medicine Greenville, University of South Carolina, 607 Grove Rd, Greenville, SC 29605, USA., Loftus G; School of Medicine, University of South Carolina, 6311 Garners Ferry Rd, Columbia, SC 29209, USA., Traylor L; School of Medicine Greenville, University of South Carolina, 607 Grove Rd, Greenville, SC 29605, USA., Goodwin R; School of Medicine Greenville, University of South Carolina, 607 Grove Rd, Greenville, SC 29605, USA., Arce S; School of Medicine Greenville, University of South Carolina, 607 Grove Rd, Greenville, SC 29605, USA.; Prisma Health Cancer Institute, Prisma Health System, 890 W Faris Rd Suite 320, Greenville, SC 29605, USA.
Publikováno v:
Vaccines [Vaccines (Basel)] 2023 Feb 05; Vol. 11 (2). Date of Electronic Publication: 2023 Feb 05.
Autor:
Mottahedin A; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge, UK; Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. Electronic address: amin.mottahedin@ndcn.ox.ac.uk., Prag HA; Department of Medicine, University of Cambridge, Cambridge University Hospitals, Cambridge, UK., Dannhorn A; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R & D, AstraZeneca, Cambridge, UK., Mair R; Division of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals, Cambridge, UK., Schmidt C; CECAD Research Center, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Yang M; CECAD Research Center, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Sorby-Adams A; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge, UK., Lee JJ; Department of Medicine, University of Cambridge, Cambridge University Hospitals, Cambridge, UK., Burger N; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge, UK., Kulaveerasingam D; Department of Medicine, University of Cambridge, Cambridge University Hospitals, Cambridge, UK., Huang MM; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge, UK., Pluchino S; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, UK., Peruzzotti-Jametti L; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, UK., Goodwin R; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R & D, AstraZeneca, Cambridge, UK., Frezza C; CECAD Research Center, Faculty of Medicine, University Hospital Cologne, Cologne, Germany., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge University Hospitals, Cambridge, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk., Krieg T; Department of Medicine, University of Cambridge, Cambridge University Hospitals, Cambridge, UK. Electronic address: tk382@medschl.cam.ac.uk.
Publikováno v:
Redox biology [Redox Biol] 2023 Feb; Vol. 59, pp. 102600. Date of Electronic Publication: 2023 Jan 02.