Zobrazeno 1 - 10 of 320 pro vyhledávání: '"Richard R Neubig"'
2
Akademický článek
Spermine in semen of male sea lamprey acts as a sex pheromone.
Autor: Anne M Scott, Zhe Zhang, Liang Jia, Ke Li, Qinghua Zhang, Thomas Dexheimer, Edmund Ellsworth, Jianfeng Ren, Yu-Wen Chung-Davidson, Yao Zu, Richard R Neubig, Weiming Li
Publikováno v: PLoS Biology, Vol 17, Iss 7, p e3000332 (2019)
Semen is fundamental for sexual reproduction. The non-sperm part of ejaculated semen, or seminal plasma, facilitates the delivery of sperm to the eggs. The seminal plasma of some species with internal fertilization contains anti-aphrodisiac molecules
Externí odkaz: https://doaj.org/article/48ca267d3d984799af6e19062845c6f3
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3
Akademický článek
Mouse models of GNAO1-associated movement disorder: Allele- and sex-specific differences in phenotypes.
Autor: Huijie Feng, Casandra L Larrivee, Elena Y Demireva, Huirong Xie, Jeff R Leipprandt, Richard R Neubig
Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0211066 (2019)
BackgroundInfants and children with dominant de novo mutations in GNAO1 exhibit movement disorders, epilepsy, or both. Children with loss-of-function (LOF) mutations exhibit Epileptiform Encephalopathy 17 (EIEE17). Gain-of-function (GOF) mutations or
Externí odkaz: https://doaj.org/article/d258bc089b254efd8bb9bf326492a2e1
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4
Akademický článek
FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
Autor: Benita Sjögren, Steven Swaney, Richard R Neubig
Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0123581 (2015)
The ubiquitin-proteasome system for protein degradation plays a major role in regulating cell function and many signaling proteins are tightly controlled by this mechanism. Among these, Regulator of G Protein Signaling 2 (RGS2) is a target for rapid
Externí odkaz: https://doaj.org/article/894e5e234bb742a683c1cda4000f9862
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5
Akademický článek
Phase-locked signals elucidate circuit architecture of an oscillatory pathway.
Autor: Andreja Jovic, Bryan Howell, Michelle Cote, Susan M Wade, Khamir Mehta, Atsushi Miyawaki, Richard R Neubig, Jennifer J Linderman, Shuichi Takayama
Publikováno v: PLoS Computational Biology, Vol 6, Iss 12, p e1001040 (2010)
This paper introduces the concept of phase-locking analysis of oscillatory cellular signaling systems to elucidate biochemical circuit architecture. Phase-locking is a physical phenomenon that refers to a response mode in which system output is synch
Externí odkaz: https://doaj.org/article/573ffac3d9af43d1830496532e96ffb1
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6
Akademický článek
BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors
Autor: Sean A. Misek, Bardees M. Foda, Thomas S. Dexheimer, Maisah Akram, Susan E. Conrad, Jens C. Schmidt, Richard R. Neubig, Kathleen A. Gallo
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Single agent and combination therapy with BRAFV600E/K and MEK inhibitors have remarkable efficacy against melanoma tumors with activating BRAF mutations, but in most cases BRAF inhibitor (BRAFi) resistance eventually develops. One resistance mechanis
Externí odkaz: https://doaj.org/article/13e3b3bcb52f4731ab7a41e5e5dd7d41
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8
Akademický článek
In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis
Autor: Aristides D. Tagalakis, Shivam Madaan, Scott D. Larsen, Richard R. Neubig, Peng T. Khaw, Ian Rodrigues, Saurabh Goyal, Kin Sheng Lim, Cynthia Yu-Wai-Man
Publikováno v: Journal of Nanobiotechnology, Vol 16, Iss 1, Pp 1-11 (2018)
Abstract Background Sustained drug delivery is a large unmet clinical need in glaucoma. Here, we incorporated a Myocardin-Related Transcription Factor/Serum Response Factor inhibitor, CCG-222740, into slow release large unilamellar vesicles derived f
Externí odkaz: https://doaj.org/article/01cbae81bc8b41f7bd5ccf2d64ab173f
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