Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Richard R, Surgenor"'
Publikováno v:
Nature Chemistry. 15:357-365
Heterobiaryl compounds that exhibit axial chirality are of increasing value and interest across several fields, but direct oxidative methods for their enantioselective synthesis remain elusive. Here we disclose that an iron catalyst in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e2fc6b6b036c067a49fc6991a76863
https://doi.org/10.1038/s41557-022-01095-9
https://doi.org/10.1038/s41557-022-01095-9
Autor:
Andrea C. Grote, Philip N. Collier, Arjun Narayanan, Catherine McGeough, Wenyu Wang, Richard R. Surgenor
Publikováno v:
The Journal of Organic Chemistry. 85:14158-14165
A direct, stereocontrolled synthesis of acyclic α-chloroenamides is presented. Our methodology showed good yields and substrate scope. Mechanistic insights are provided that account for the high levels of stereoselectivity reported. Subsequent synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91237f1a7078c6d665d7436533187ab0
https://doi.org/10.1021/acs.joc.0c01370
https://doi.org/10.1021/acs.joc.0c01370
Publikováno v:
Nature chemistry.
Heterobiaryl compounds that exhibit axial chirality are of increasing value and interest across several fields, but direct oxidative methods for their enantioselective synthesis remain elusive. Here we disclose that an iron catalyst in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e3dd05f774f8d49d72741c521a9e2265
https://pubmed.ncbi.nlm.nih.gov/36509852
https://pubmed.ncbi.nlm.nih.gov/36509852
Publikováno v:
Organic letters. 17(21)
The isolation and total synthesis of the antimicrobial lipopeptide cerexin A1 is reported. This synthesis includes the preparation of orthogonally protected γ-hydroxylysine, utilizing a nitrile Reformatsky-type reaction as a key step to yield both d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8813acc184317ed871fdf1115f05d963
https://pubmed.ncbi.nlm.nih.gov/26465807
https://pubmed.ncbi.nlm.nih.gov/26465807
Autor:
Parker MJ; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Lee H; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Yao S; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Irwin S; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Hwang S; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Belanger K; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., de Mare SW; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Surgenor R; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Yan L; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Gee P; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Morla S; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Puyang X; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Hsiao P; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Zeng H; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Zhu P; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Korpal M; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Dransfield P; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Bolduc DM; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States., Larsen NA; H3 Biomedicine, Inc., 300 Technology Square, Suite 5, Cambridge, Massachusetts 02139, United States.
Publikováno v:
Biochemistry [Biochemistry] 2023 Jul 18; Vol. 62 (14), pp. 2147-2160. Date of Electronic Publication: 2023 Jul 05.