Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Richard P. Paczynski"'
Publikováno v:
International Journal of Risk & Safety in Medicine. 24:137-146
Public and private payers use drug compendia to make coverage determinations, yet the quality of evidence they contain has received little scrutiny. We examined compendia citations regarding antipsychotic drugs, an important drug class given their su
Publikováno v:
International Journal of Risk and Safety in Medicine. 21:139-145
Background: Because type II diabetes is currently more prevalent in schizophrenics than non-schizophrenics, some investigators have postulated a more fundamental association between these two disorders. However, there is a paucity of evidence concern
Publikováno v:
Journal of Medical Regulation. 94:16-22
Misconduct in clinical research jeopardizes the integrity of medical science. Physician researcher misconduct that produces flawed results has consequences, including the subsequent inability of other physicians who rely on erroneous data to provide
Publikováno v:
International Journal of Risk and Safety in Medicine. 20:37-44
Pharmacologic intervention at the earliest stages of suspected psychotic illness is an intuitively appealing concept and a logical extension of the current approach to many other diseases of the central nervous system. Atypical antipsychotic agents (
Autor:
Kilichan Gurleyik, Richard P. Paczynski, Ramesh Venkatesan, Chung Y. Hsu, Weili Lin, William J. Powers, Yong Y. He
Publikováno v:
Magnetic Resonance in Medicine. 43:146-150
Using a magnetic resonance (MR) imaging method, absolute measurements of in vivo brain water content were obtained in 15 male Long Evans rats that underwent a 90-min focal cerebral ischemia. A strong linear relationship (r = 0.80) with a slope of 1 w
Publikováno v:
Scopus-Elsevier
Acute hypercapnia simultaneously induces increases in regional cerebral blood volume (rCBV) and the oxygen saturation of cerebral venous blood (Yv). Changes in both physiologic parameters may influence the changes in R2* (ΔR2*) that can be measured
Publikováno v:
Scopus-Elsevier
T2*-weighted gradient echo magnetic resonance images of rat brain were obtained dynamically during acute hypoxemic hypoxia to investigate the relations between changes in cerebral blood oxygen saturation(ΔYb), blood hematocrit (Hct), and R2* (ΔR2*)
Publikováno v:
Magnetic Resonance in Medicine. 38:420-428
A three-dimensional (3D) T 1 -weighted sequence was used to acquire high spatial resolution whole brain images in rats before and after the injection of an intravascular contrast agent. These T 1 -weighted images were used to estimate regional cerebr
Publikováno v:
Stroke. 28:1437-1444
Background and Purpose Repeated use of mannitol in the setting of ischemic infarction is a controversial and poorly defined therapeutic intervention. The purpose of this study was to examine the effects of repeated mannitol infusions on brain water c
Autor:
Richard P. Paczynski
Publikováno v:
Critical Care Clinics. 13:105-129
Osmotherapy with compounds such as mannitol has become a mainstay of neurologic and neurosurgical intensive care. Elevated intracranial pressure is the most common indication. A substantive debate remains as to the appropriate timing of administratio