Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Richard P. Haynes"'
Autor:
Michelle. A. Goonasekera, Alison Offer, Waseem Karsan, Muram El-Nayir, Amy E. Mallorie, Sarah Parish, Richard J. Haynes, Marion M. Mafham
Publikováno v:
Systematic Reviews, Vol 13, Iss 1, Pp 1-15 (2024)
Abstract Background Ascertainment of heart failure (HF) hospitalizations in cardiovascular trials is costly and complex, involving processes that could be streamlined by using routinely collected healthcare data (RCD). The utility of coded RCD for HF
Externí odkaz:
https://doaj.org/article/bdb8de8e18f44b0ab92fd3b98d21e0dc
Autor:
Daniel J. Watson, Lizahn Laing, Jacobus P. Petzer, Ho Ning Wong, Christopher J. Parkinson, Lubbe Wiesner, Richard K. Haynes
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Efforts to develop new artemisinin triple combination therapies effective against artemisinin-tolerant strains of Plasmodium falciparum based on rational combinations comprising artemisone or other amino-artemisinins, a redox active drug and a third
Externí odkaz:
https://doaj.org/article/f0b32b20533b40e5ab69e8781098f068
Autor:
Joachim Müller, Carling Schlange, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Richard K. Haynes, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 1-12 (2023)
The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the pero
Externí odkaz:
https://doaj.org/article/ab6fe9874f28493880edaf6ef7fc235c
Publikováno v:
Methods and Protocols, Vol 6, Iss 6, p 104 (2023)
We describe the development and validation of a new high performance liquid chromatography (HPLC) method for analysis of a combination of the first-line anti-tubercular drugs isoniazid, pyrazinamide, and rifampicin together with clofazimine. This is
Externí odkaz:
https://doaj.org/article/4c1cf7658abd48afa6851e9d1ef5c3c1
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1348 (2023)
Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that are superior to other lipid-based oral drug delivery systems in terms of providing drug protection against the gastrointestinal (GI) environment, inhibition of drug efflux a
Externí odkaz:
https://doaj.org/article/84b8a9f290fe49088e58e32e8c4e5829
Autor:
Jerome P. L. Ng, Yu Han, Li Jun Yang, Lyn-Marie Birkholtz, Dina Coertzen, Ho Ning Wong, Richard K. Haynes, Paolo Coghi, Vincent Kam Wai Wong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Artemisinin, isolated from the traditional Chinese medicinal plant qīng hāo 青蒿 (Artemisia annua) and its derivatives are used for treatment of malaria. With treatment failures now being recorded for the derivatives and companion drugs used in a
Externí odkaz:
https://doaj.org/article/b5bdae38dcd7468283dd4e8dfca5fc88
Autor:
Daniel J. Watson, Lizahn Laing, Richard M. Beteck, Liezl Gibhard, Richard K. Haynes, Lubbe Wiesner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The emergence of Plasmodium falciparum (Pf) parasite strains tolerant of the artemisinin component and resistant to the other drug component in artemisinin combination therapies (ACTs) used for treatment now markedly complicates malaria control. Thus
Externí odkaz:
https://doaj.org/article/0fa9857392ad4a1886dbda6556e86f19
Autor:
Lorencia Taljaard, Alexandra Probst, Robert Tornow, Jennifer Keiser, Richard K. Haynes, Frank van der Kooy
Publikováno v:
Phytomedicine Plus, Vol 2, Iss 3, Pp 100279- (2022)
Background: Schistosomiasis, a neglected tropical disease, imposes substantial health and economic burdens on impoverished groups living in predominantly rural areas. Praziquantel (PZQ) is the only drug available for treatment, and it is not complete
Externí odkaz:
https://doaj.org/article/505302c9eb5b43359d033ce34cbf9493
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1293 (2023)
Self-emulsification is considered a formulation technique that has proven capacity to improve oral drug delivery of poorly soluble drugs by advancing both solubility and bioavailability. The capacity of these formulations to produce emulsions after m
Externí odkaz:
https://doaj.org/article/85f9e3e7ed00477e8b59c7ecdd8d2b00
Autor:
Jessica Ramseier, Dennis Imhof, Kai Pascal Alexander Hänggeli, Nicoleta Anghel, Ghalia Boubaker, Richard M. Beteck, Luis-Miguel Ortega-Mora, Richard K. Haynes, Andrew Hemphill
Publikováno v:
Pathogens, Vol 12, Iss 3, p 447 (2023)
The effects of decoquinate (DCQ) and three O-quinoline-carbamate-derivatives were investigated using human foreskin fibroblasts (HFF) infected with Neospora caninum tachyzoites. These compounds exhibited half-maximal proliferation inhibition (IC50s)
Externí odkaz:
https://doaj.org/article/54d7f83ce6a34fad8ff630573d8953d0