Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Richard P. H. Huijbregts"'
Autor:
Ashley N. Connelly, Richard P. H. Huijbregts, Harish C. Pal, Valeriya Kuznetsova, Marcus D. Davis, Krystle L. Ong, Christian X. Fay, Morgan E. Greene, Edgar T. Overton, Zdenek Hel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Neutrophils are the most abundant circulating leukocyte population with critical roles in immune defense, regulation of innate and adaptive immune systems, and disease pathogenesis. Our progress in understanding precise mechanisms of neutrop
Externí odkaz:
https://doaj.org/article/6b8d06a67b1c44c3b330ffebdad63b65
Autor:
Harish C. Pal, Zdenek Hel, Morgan E. Greene, Marcus Darrell Davis, Valeriya Kuznetsova, Christian X. Fay, Ashley Nicole Connelly, Krystle L. Ong, Richard P. H. Huijbregts, Edgar T. Overton
Neutrophils are the most abundant circulating leukocyte population with critical roles in immune defense, regulation of innate and adaptive immune systems, and disease pathogenesis. Our progress in understanding precise mechanisms of neutrophil activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9662b2e48a11992002101ef1723b1a9b
https://doi.org/10.21203/rs.3.rs-959537/v1
https://doi.org/10.21203/rs.3.rs-959537/v1
Autor:
Nathan L Bowers, E Scott Helton, Richard P H Huijbregts, Paul A Goepfert, Sonya L Heath, Zdenek Hel
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003993 (2014)
HIV-1 infection is associated with a progressive loss of T cell functional capacity and reduced responsiveness to antigenic stimuli. The mechanisms underlying T cell dysfunction in HIV-1/AIDS are not completely understood. Multiple studies have shown
Externí odkaz:
https://doaj.org/article/83303f7c6dcb42d383f87d587b4720f7
Autor:
Holly E. Richter, Katherine G. Michel, Jonathan L. Gleason, Richard P. H. Huijbregts, Zdenek Hel
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 68:511-518
OBJECTIVE: Epidemiological evidence suggests an association between the use of hormonal contraception and an increased risk of acquiring sexually transmitted diseases including HIV-1. We sought to elucidate the biological mechanisms underlying the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b0d31e19be774efc66dc94248a7dc1
https://doi.org/10.1097/qai.0000000000000531
https://doi.org/10.1097/qai.0000000000000531
Publikováno v:
Molecular Biology of the Cell
Detailed roles of conserved septin motifs, GTP, and Orc6 in Drosophila septin complex functions are examined both in vitro and in vivo in a live animal. A novel mechanism of Orc6 regulation of septin filament formation is presented.
Septins belo
Septins belo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058612ded5c21e36ec1c4825ae04df0d
http://europepmc.org/articles/PMC4279225
http://europepmc.org/articles/PMC4279225
Autor:
E. Scott Helton, Charles O. Elson, Zdenek Hel, Jun Xu, Benjamin S. Christmann, Sonya L. Heath, Jiri Mestecky, E. Turner Overton, Richard P. H. Huijbregts, Warren Denning, Paul A. Goepfert
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006087 (2017)
PLoS Pathogens
PLoS Pathogens
HIV-1 infection is associated with an early and profound depletion of mucosal memory CD4+ T cells, a population that plays an indispensable role in the regulation of isotype switching and transepithelial transport of antibodies. In this study, we add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebfd740d0e602ba79ad2ab056a24e04
http://europepmc.org/articles/PMC5268400?pdf=render
http://europepmc.org/articles/PMC5268400?pdf=render
Autor:
Jun Xu, Jiri Litzman, Richard P. H. Huijbregts, Zdenek Hel, Marcela Vlková, Jana Nechvatalova
Publikováno v:
Journal of Clinical Immunology. 34:971-978
Common variable immunodeficiency (CVID) is the most frequent form of primary symptomatic hypogammaglobulinemia. CVID patients display a number of abnormalities in lymphocyte subpopulations including chronic T-cell activation and decreased numbers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecb2c0dc85b34af12b23bbcf6e66720
https://doi.org/10.1007/s10875-014-0099-z
https://doi.org/10.1007/s10875-014-0099-z
Autor:
Steven L. Carroll, Kevin A. Roth, Fady M. Mikhail, Syed A. Jaffar Kazmi, Richard P. H. Huijbregts, William E. Grizzle, Jenell M. Eckert, Nicole M. Brossier, Stephanie J. Byer, Amy N. Turk
Publikováno v:
The American Journal of Pathology. 182:646-667
Patients with neurofibromatosis type 1 (NF1) develop benign plexiform neurofibromas that frequently progress to become malignant peripheral nerve sheath tumors (MPNSTs). A genetically engineered mouse model that accurately models plexiform neurofibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279a7df91bfbcdc879d52660f8953e48
https://doi.org/10.1016/j.ajpath.2012.11.017
https://doi.org/10.1016/j.ajpath.2012.11.017
Publikováno v:
Proceedings of the National Academy of Sciences. 106:10672-10677
The origin recognition complex (ORC) is a 6-subunit complex required for the initiation of DNA replication in eukaryotic organisms. ORC is also involved in other cell functions. The smallest Drosophila ORC subunit, Orc6, is important for both DNA rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28efa55b529cfd40d4774aaa1464807f
https://doi.org/10.1073/pnas.0902670106
https://doi.org/10.1073/pnas.0902670106
Publikováno v:
Molecular and Cellular Biology. 27:3143-3153
The six-subunit origin recognition complex (ORC) is a DNA replication initiator protein in eukaryotes that defines the localization of the origins of replication. We report here that the smallest Drosophila ORC subunit, Orc6, is a DNA binding protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::567046ec85b6951756dbf65c24160e8d
https://doi.org/10.1128/mcb.02382-06
https://doi.org/10.1128/mcb.02382-06