Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Richard P. DiAugustine"'
Publikováno v:
Journal of Biological Chemistry. 279:6883-6892
Troglitazone (TGZ) and 15-deoxy-Delta(12,14)-prostaglandin J2 (PGJ2) are peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands that have been shown to possess pro-apoptotic activity in human colon cancer. Although these compounds bind
Autor:
Jonathan Lindzey, Michele Raviscioni, Richard P. DiAugustine, Julie F. Foley, Paolo Ciana, Diane M. Klotz, Kenneth S. Korach, Sylvia C. Hewitt, Adriana Maggi
Publikováno v:
Journal of Biological Chemistry. 277:8531-8537
In the uterus insulin-like growth factor-1 (IGF-1) signaling can be initiated by estradiol acting through its nuclear receptor (estrogen receptor (ER)) to stimulate the local synthesis of IGF-1. Conversely, in vitro studies have demonstrated that est
Publikováno v:
Endocrinology. 142:3842-3849
The insulin receptor substrates are docking proteins that bind various receptor tyrosine kinases and signaling proteins. Previous studies have shown that E2 or progesterone can regulate the relative abundance of insulin receptor substrate-1 and -2 in
Autor:
Richard P. DiAugustine, Darlene Dixon, John I. Risinger, David K. Walmer, Retha R. Newbold, Jeffrey I. Everitt, Estella C. Parrott
Publikováno v:
Environmental Health Perspectives. 108:769-773
Uterine leiomyomas (fibroids, myomas) are the most common tumors occurring in the genital tract of women over 30 years of age. These benign uterine smooth-muscle tumors are estimated to be clinically significant in at least 25% of the American female
Publikováno v:
Endocrinology. 141:3430-3439
Recent data indicate that insulin-like growth factor I (IGF-I) may have a function in mediating the mitogenic effects of 17beta-estradiol (E2) in the uterus and in regulating the growth of uterine neoplasms. This study was designed to determine wheth
Publikováno v:
Journal of Biological Chemistry. 273:11962-11969
Some of the actions of estradiol occur through stimulation of growth factor pathways in target organs. Tyrosine-phosphorylated (Tyr(P)) insulin-like growth factor-1 receptor (IGF-1R) and the insulin receptor substrate (IRS)-1 are found in the uterus
Publikováno v:
Journal of Mammary Gland Biology and Neoplasia. 2:109-117
The discovery of multiple EGF-like ligands and erbB receptors offers the potential for a highly diverse signaling system allowing specific ligand/receptor complexes to be created in response to a certain hormone(s) or stage of mammary development. Th
Publikováno v:
Proceedings of the National Academy of Sciences. 93:12002-12007
The signaling pathways associated with estrogen-induced proliferation of epithelial cells in the reproductive tract have not been defined. To identify receptor tyrosine kinases that are activated in vivo by 17 beta-estradiol (E2), uteri from ovariect
Publikováno v:
Molecular and Cellular Biology. 35:4094-4094
Publikováno v:
Environmental Health Perspectives
Bioengineering of the mammary gland to produce proteins of therapeutic and industrial value is the result of extensive investigation of the physiology of the mammary gland and the ability to generate transgenic animals. Targeting the expression of he