Výsledky vyhledávání - "Richard P. Woychik"

Akademický článek

The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development

Publikováno v: Developmental Cognitive Neuroscience, Vol 69, Iss , Pp 101423- (2024)

The human brain undergoes rapid development during the first years of life. Beginning in utero, a wide array of biological, social, and environmental factors can have lasting impacts on brain structure and function. To understand how prenatal and ear

Externí odkaz: https://doaj.org/article/c628e88449864b67a8b01eb2762b6abb

Zobrazit plný text záznamu

Akademický článek

A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data

Autor: Oswaldo A. Lozoya, Janine H. Santos, Richard P. Woychik

Publikováno v: Frontiers in Genetics, Vol 9 (2018)

To life scientists, one important feature offered by RNAseq, a next-generation sequencing tool used to estimate changes in gene expression levels, lies in its unprecedented resolution. It can score countable differences in transcript numbers among th

Externí odkaz: https://doaj.org/article/6424576df8764681abf1a4f53861354a

Zobrazit plný text záznamu

Akademický článek

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

Autor: Oswaldo A Lozoya, Inmaculada Martinez-Reyes, Tianyuan Wang, Dagoberto Grenet, Pierre Bushel, Jianying Li, Navdeep Chandel, Richard P Woychik, Janine H Santos

Publikováno v: PLoS Biology, Vol 16, Iss 4, p e2005707 (2018)

Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a

Externí odkaz: https://doaj.org/article/956885ce10ee49b489a6dee1a030f6e2

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

A Novel Analytical Strategy to Identify Fusion Transcripts between Repetitive Elements and Protein Coding-Exons Using RNA-Seq.

Autor: Tianyuan Wang, Janine H Santos, Jian Feng, David C Fargo, Li Shen, Gonzalo Riadi, Elizabeth Keeley, Zachary S Rosh, Eric J Nestler, Richard P Woychik

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159028 (2016)

Repetitive elements (REs) comprise 40-60% of the mammalian genome and have been shown to epigenetically influence the expression of genes through the formation of fusion transcript (FTs). We previously showed that an intracisternal A particle forms a

Externí odkaz: https://doaj.org/article/15d56a31a03a4d48a3ac2c70ab092a7d

Zobrazit plný text záznamu

Rapid Scaling Up of Covid-19 Diagnostic Testing in the United States — The NIH RADx Initiative

Autor: Bruce J. Tromberg, Richard J. Hodes, Tara A. Schwetz, Rachael L. Fleurence, Rick A. Bright, Francis S. Collins, Eliseo J. Pérez-Stable, Richard P. Woychik

Publikováno v: The New England Journal of Medicine
New England Journal of Medicine

RADx — Rapid Scaling Up of Covid-19 Testing In April 2020, Congress appropriated $1.5 billion to the NIH to increase national testing capacity for SARS-CoV-2. The NIH established the Rapid Accelera...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2e1607b23f7ba0d575866fac8c913a
http://europepmc.org/articles/PMC7493127

Zobrazit plný text záznamu

Correction: A brain-specific PGC1a fusion transcript affects gene expression and behavioral outcomes in mice

Autor: Jesse D. Cushman, Gonzalo Riadi, Janine H. Santos, Sheryl S. Moy, Patricia Jensen, Oswaldo A. Lozoya, Tianyuan Wang, Fuhua Xu, Richard P. Woychik, Dagoberto Grenet, Artiom Gruzdev, Thomas B Hagler, Korey D. Stevanovic, Bairon Hernandez

Publikováno v: Life Science Alliance

This study shows that loss of a brain-specific fusion isoform of PGC1a leads to up-regulation of genes and motor impairments in mice, suggesting functional differences between PGC1 isoforms in the brain.
PGC1α is a transcriptional coactivator i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5d14ad72249ac0290d81facc8447e7
https://pubmed.ncbi.nlm.nih.gov/34649938

Zobrazit plný text záznamu

Patterns, Profiles, and Parsimony: Dissecting Transcriptional Signatures From Minimal Single-Cell RNA-Seq Output With SALSA

Autor: Humphrey H.-C. Yao, Kathryn S. McClelland, Brian N. Papas, Jian-Liang Li, Oswaldo A. Lozoya, Richard P. Woychik

Publikováno v: Frontiers in Genetics, Vol 11 (2020)
Frontiers in Genetics

Single-cell RNA sequencing (scRNA-seq) technologies have precipitated the development of bioinformatic tools to reconstruct cell lineage specification and differentiation processes with single-cell precision. However, start-up costs and data volumes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be81e28191c4adb7dc70a7d5cd429733
https://www.frontiersin.org/article/10.3389/fgene.2020.511286/full

Zobrazit plný text záznamu

A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice

Autor: Sheryl S. Moy, Bairon Hernandez, Korey D. Stevanovic, Dagoberto Grenet, Oswaldo A. Lozoya, Jesse D. Cushman, Artiom Gruzdev, Thomas B Hagler, Fuhua Xu, Patricia Jensen, Richard P. Woychik, Gonzalo Riadi, Janine H. Santos, Tianyuan Wang

Publikováno v: Life Science Alliance. 4:e202101122

PGC1α is a transcriptional coactivator in peripheral tissues, but its function in the brain remains poorly understood. Various brain-specific Pgc1α isoforms have been reported in mice and humans, including two fusion transcripts (FTs) with non-codi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9541fe6cd3ff63d0eec3228d0e6aac5
https://doi.org/10.26508/lsa.202101122

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání