Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Richard P, Junghans"'
Autor:
Ancy Thomas, Saurav Sumughan, Emilia R. Dellacecca, Rohan S. Shivde, Nicola Lancki, Zhussipbek Mukhatayev, Cristina C. Vaca, Fei Han, Levi Barse, Steven W. Henning, Jesus Zamora-Pineda, Suhail Akhtar, Nikhilesh Gupta, Jasmine O. Zahid, Stephanie R. Zack, Prathyaya Ramesh, Dinesh Jaishankar, Agnes S.Y. Lo, Joel Moss, Maria M. Picken, Thomas N. Darling, Denise M. Scholtens, Daniel F. Dilling, Richard P. Junghans, I. Caroline Le Poole
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Mutations underlying disease in tuberous sclerosis complex (TSC) give rise to tumors with biallelic mutations in TSC1 or TSC2 and hyperactive mammalian target of rapamycin complex 1 (mTORC1). Benign tumors might exhibit de novo expression of immunoge
Externí odkaz:
https://doaj.org/article/f0d788c1bbd34b7ead95bd619eb9df37
Autor:
Richard Paul Junghans
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 17, Iss 12, Pp 5133-5134 (2021)
COVID-19 trials have relied on symptomatic subjects for judging the effectiveness of vaccine candidates, whereas asy–mptomatic subjects have been suspected as the main driver of the pandemic. An assumption of the same impact on symptomatic and asym
Externí odkaz:
https://doaj.org/article/2ce6713232714e16a5bf901ea39e8cbc
Autor:
Zhussipbek Mukhatayev, Emilia R. Dellacecca, Cormac Cosgrove, Rohan Shivde, Dinesh Jaishankar, Katherine Pontarolo-Maag, Jonathan M. Eby, Steven W. Henning, Yekaterina O. Ostapchuk, Kettil Cedercreutz, Alpamys Issanov, Shikhar Mehrotra, Andreas Overbeck, Richard P. Junghans, Joseph R. Leventhal, I. Caroline Le Poole
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs can provide protection against depigmentation. Ganglioside D3 (GD3
Externí odkaz:
https://doaj.org/article/2aa1452d89f0471bb166b8aac11bb57f
Autor:
Kenneth Cornetta, Lisa Duffy, Steven A. Feldman, Crystal L. Mackall, Marco L. Davila, Kevin J. Curran, Richard P. Junghans, Jean Yuh Tang, James N. Kochenderfer, Roisin O’Cearbhaill, Gary Archer, Hans-Peter Kiem, Nirali N. Shah, Cindy Delbrook, Rosie Kaplan, Renier J. Brentjens, Isabelle Rivière, Michel Sadelain, Steven A. Rosenberg
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 371-378 (2018)
Replication-competent retrovirus (RCR) is a safety concern for individuals treated with retroviral gene therapy. RCR detection assays are used to detect RCR in manufactured vector, transduced cell products infused into research subjects, and in the r
Externí odkaz:
https://doaj.org/article/d41ec9a65e514c438579bc848efe4243
Publikováno v:
iScience, Vol 2, Iss , Pp 105-122 (2018)
Summary: T cells infiltrate affected organs in chronic infections and malignancy, but they may fail to eradicate virus-infected cells or tumor because of exhaustion. This report describes a Yin Yang-1 (YY1)-centered mechanism for diverse components t
Externí odkaz:
https://doaj.org/article/054e0a0af77f42cab1650b88fc558a45
Autor:
Prakash Sampath, Richard P. Junghans, Henry Brem, Bob S. Carter, Ayguen Sahin, Jinyuan Zhou, Saryn Doucette, Qiangzhong Ma, Anthony J. Bais, Betty Tyler, Sadhak Sengupta, Seogkyoung Kong
Purpose: Glioblastoma multiforme (GBM) remains highly incurable, with frequent recurrences after standard therapies of maximal surgical resection, radiation, and chemotherapy. To address the need for new treatments, we have undertaken a chimeric anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250d2e5a5e9dbebb1acf0ed4e3bd9c6d
https://doi.org/10.1158/1078-0432.c.6520563
https://doi.org/10.1158/1078-0432.c.6520563
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Supplemental Figure 1. In vitro cytotoxicity assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e4f36b3128e8a08781410abb288250
https://doi.org/10.1158/1078-0432.22458323
https://doi.org/10.1158/1078-0432.22458323
Autor:
Richard P. Junghans, Rosa M. Gonzalo-Daganzo, David L. Liu, Erica M. Gomes, Agnes S.Y. Lo, Peter C.R. Emtage
Purpose: This report describes the development and preclinical qualification tests of second-generation anti-carcinoembryonic (CEA) designer T cells for use in human trials.Experimental Design: The progenitor first-generation immunoglobulin-T-cell re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609f06263a3fd6e3e52001c2a003e799
https://doi.org/10.1158/1078-0432.c.6517050
https://doi.org/10.1158/1078-0432.c.6517050
Autor:
Richard P. Junghans, Rosa M. Gonzalo-Daganzo, David L. Liu, Erica M. Gomes, Agnes S.Y. Lo, Peter C.R. Emtage
Supplementary Data from Second-Generation Anti–Carcinoembryonic Antigen Designer T Cells Resist Activation-Induced Cell Death, Proliferate on Tumor Contact, Secrete Cytokines, and Exhibit Superior Antitumor Activity In vivo: A Preclinical Evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630a40d59c3a5498dfe3137da91c74a5
https://doi.org/10.1158/1078-0432.22439610.v1
https://doi.org/10.1158/1078-0432.22439610.v1
Autor:
Richard P. Junghans, N. Joseph Espat, Robin Davies, Earle O. Assanah, Brian F. Stainken, Qiangzhong Ma, Mitchell Thorn, Pranay D. Khare, Gary R. Point, Wesley Mooring, Li Juan Wang, Elise McCormack, Rachel A. Burga, Steven C. Katz
Purpose: Chimeric antigen receptor–modified T cells (CAR-T) have demonstrated encouraging results in early-phase clinical trials. Successful adaptation of CAR-T technology for CEA-expressing adenocarcinoma liver metastases, a major cause of death i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c749b8413a71355a55dddb9a20c880e
https://doi.org/10.1158/1078-0432.c.6523904.v1
https://doi.org/10.1158/1078-0432.c.6523904.v1