Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Richard N. Loeppky"'
Publikováno v:
Chirality. 27:18-22
The C-arylglycosides are available in enantiomerically pure form via the Dotz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O-carbamate directed ipso
Autor:
Jianzheng Shi, Richard N Loeppky
Publikováno v:
Chemical Research in Toxicology. 21:319-329
The reaction of N-nitrosotolazoline, the nitrosation product of a representative imidazoline receptor drug tolazoline, with DNA, deoxyguanosine (dG), or deoxyadenosine (dA) produces adducts containing the 2-phenylacetamidoethyl group. The synthesis a
Publikováno v:
ACS Chemical Biology. 2:286-292
The first Chemistry in Cancer Research Conference jointly presented by the American Chemical Society (ACS) and American Association for Cancer Research (AACR) was hosted by the Chemistry in Cancer Research Working Group (CICR) of the AACR, February 4
Publikováno v:
The Journal of Organic Chemistry. 70:6790-6801
The results are presented of a theoretical study of the nitrosation chemistry of pyrroline 1 (X = CH2), imidazoline 2 (X = NH), and 2-oxazoline 3 (X = O). Imines 1-3 are converted to the alpha-hydroxy-N-nitrosamines 7-9 via the N-nitrosoiminium ions
Autor:
Michelle K Dennehy, Richard N. Loeppky
Publikováno v:
Chemical Research in Toxicology. 18:556-565
N-Nitrosodiethanolamine (NDELA) is a bident carcinogen that undergoes both P-450 mediated alpha-hydroxylation and beta-oxidation, leading ultimately to the formation of two prominent DNA adducts, glyoxaldeoxyguanosine (gdG) and O6-2-hydroxyethyldeoxy
Autor:
Petra Goelzer, Richard N. Loeppky
Publikováno v:
Chemical Research in Toxicology. 15:457-469
N-Nitrosodiethanolamine (NDELA), an environmentally prevalent, potent carcinogen, undergoes competitive rat liver microsome-mediated oxidation at both the alpha (adjacent to N)- and beta-positions of the 2-hydroxyethyl chains. The former process, alp
Publikováno v:
Chemical Research in Toxicology. 15:470-482
The mechanism by which environmentally prevalent N-nitrosodiethanolamine (NDELA) and related 2-hydroxyethyl- or other beta-oxidized nitrosamines initiate the carcinogenic process has remained obscure. (32)P-Postlabeling assays for the pH sensitive gl
Autor:
Wenge Cui, Richard N. Loeppky
Publikováno v:
Tetrahedron. 57:2953-2956
A variety of N-arylcyclopropylamines has been prepared in one step, by the Pd2(dba)3/BINAP/NaOtBu-catalyzed amination of an aryl bromide with cyclopropylamine. Compounds bearing the N-aryl substitutent (phenyl, 4-methylphenyl, 2-methoxyphenyl, 3-meth
Autor:
Richard N. Loeppky, Misun Park
Publikováno v:
Chemical Research in Toxicology. 13:72-81
The deamination of DNA bases by three alpha-nitrosaminoaldehydes, butylethanalnitrosamine, methylethanalnitrosamine, and N-nitroso-2-hydroxymorpholine (NHMOR), the direct metabolite of potent animal carcinogen N-nitrosodiethanolamine, was demonstrate
Autor:
Saleh Elomari, Richard N. Loeppky
Publikováno v:
The Journal of Organic Chemistry. 65:96-103
A group of N-cyclopropyl-N-alkylanilines has been synthesized, and their reaction with nitrous acid in aqueous acetic acid at 0 degrees C was examined. All compounds reacted rapidly to produce the corresponding N-alkyl-N-nitrosoaniline by specific cl