Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Richard N. Hill"'
Autor:
Vicki L. Dellarco, John R. Bucher, M. E. Meek, David G. Longfellow, Richard N. Hill, Jennifer Seed, Dorothy E. Patton, Samuel M. Cohen, Timothy P. Pastoor, Lois D. Lehman-McKeeman
Publikováno v:
Critical Reviews in Toxicology. 33:591-653
The human relevance framework (HRF) outlines a four-part process, beginning with data on the mode of action (MOA) in laboratory animals, for evaluating the human relevance of animal tumors. Drawing on U.S. EPA and IPCS proposals for animal MOA analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eeb8de69ca4faca15a9e0fab53e6545
https://doi.org/10.1080/713608373
https://doi.org/10.1080/713608373
Publikováno v:
Regulatory Toxicology and Pharmacology. 34:249-257
New test methods are being developed to improve the prediction of human and environmental risks and to benefit animal welfare by reducing, refining, and replacing animal use. Regulatory adoption of new test methods is often a complex and protracted p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5353cb2d1a03afac04973d991690ebea
https://doi.org/10.1006/rtph.2001.1496
https://doi.org/10.1006/rtph.2001.1496
Publikováno v:
Food and Chemical Toxicology. 35:175-178
In November 1993, the Interagency Regulatory Alternatives Group (IRAG) sponsored a workshop to examine the current scientific status of alternatives to the Draize eye irritation test by assessing the current practical application of methods used to p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c001300d688a4f6c19802260f4dd1aca
https://doi.org/10.1016/s0278-6915(96)00110-x
https://doi.org/10.1016/s0278-6915(96)00110-x
Autor:
Michael S. Dickens, Richard N. Hill, Alan M. Goldberg, Robert A. Scala, Kevin J. Renskers, Stephen D. Gettings, David Brusick, Oliver P. Flint, N.L. Wilcox, Sidney Green, Robert L. Lipnick, Bellina Veronesi, June A. Bradlaw, John M. Frazier, Rodger Curren
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 29:688-692
The development and application of in vitro alternatives designed to reduce or replace the use of animals, or to lessen the distress and discomfort of laboratory animals, is a rapidly developing trend in toxicology. However, at present there is no fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e9995ad68ec5712e13a90146806c75
https://doi.org/10.1007/bf02631424
https://doi.org/10.1007/bf02631424
Autor:
D.K. Lowther, W.A. Chambers, K.C. Gupta, V.M. Seabaugh, P.T. Liu, N.L. Wilcox, Sidney Green, J.A. Springer, P.M. Hurley, L.A. Lambert, Richard N. Hill
Publikováno v:
Food and Chemical Toxicology. 31:117-121
An in vivo test protocol and an evaluation and classification system for the determination of eye irritation potential of chemicals and mixtures (substances) is proposed. The protocol uses two or three rabbits and reduces distress in test animals. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd6150729fcb5c41920433867c055ac
https://doi.org/10.1016/0278-6915(93)90124-h
https://doi.org/10.1016/0278-6915(93)90124-h
Autor:
J.A. Springer, V.M. Seabaugh, C.D. Roberts, L.A. Lambert, Richard N. Hill, K.C. Gupta, C.C. Lee, N.L. Wilcox, Sidney Green, J.K. Lee, P.T. Liu, P.M. Hurley, D.K. Lowther, W.A. Chambers
Publikováno v:
Food and Chemical Toxicology. 31:99-103
The Draize rabbit eye test was developed to provide a method for assessing the irritation potential of materials that might come in contact with human eyes. The method involves the instillation of 0.1 ml of a test liquid (100 mg solid) into the conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6a24ef5ac0628cec11477eaba28c77
https://doi.org/10.1016/0278-6915(93)90121-e
https://doi.org/10.1016/0278-6915(93)90121-e
Autor:
L.A. Lambert, P.M. Hurley, J.K. Lee, C.D. Roberts, N.L. Wilcox, Sidney Green, V.M. Seabaugh, C.C. Lee, D.K. Lowther, W.A. Chambers, K.C. Gupta, P.T. Liu, J.A. Springer, Richard N. Hill
Publikováno v:
Food and Chemical Toxicology. 31:95-98
Pretreatment of the eyes of rabbits with a topical anaesthetic can be viewed as a refinement of the test for eye irritation. It reduces pain at the time of test-material administration, decreases animal distress and permits easier application of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51799adcc0bda65dbff6d5e36f08d5a
https://doi.org/10.1016/0278-6915(93)90120-n
https://doi.org/10.1016/0278-6915(93)90120-n
Autor:
Kevin J. Renskers, S.D. Gettings, Michael S. Dickens, Robert L. Lipnick, Richard N. Hill, N.L. Wilcox, June A. Bradlaw, Oliver P. Flint, John M. Frazier, Sidney Green, D. Brusick, R. D. Curren, Alan M. Goldberg, R. A. Scala, Bellina Veronesi
Publikováno v:
Xenobiotica. 23:563-572
The development and application of in vitro alternatives designed to reduce or replace the use of animals, or to lessen the distress and discomfort of laboratory animals, is a rapidly developing trend in toxicology. However, at present there is no fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00da9d8874db08d87dbf4f337ad0e80
https://doi.org/10.3109/00498259309059395
https://doi.org/10.3109/00498259309059395
Autor:
Robert L. Lipnick, Kevin J. Renskers, Bellina Veronesi, Michael S. Dickens, Robert A. Scala, Richard N. Hill, Oliver Flint, Stephen D. Gettings, June A. Bradlaw
Publikováno v:
Journal of the American College of Toxicology. 12:23-30
In toxicology the development and application of in vitro alternatives to reduce or replace animal testing, or to lessen the distress and discomfort of laboratory animals, is a rapidly developing trend. However, at present there is no formal administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e748b9c7c9d66e2966af257349aba271
https://doi.org/10.3109/10915819309140619
https://doi.org/10.3109/10915819309140619