Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Richard N. Harkins"'
Autor:
Irene Kuhn, Paul Harden, Maxine Bauzon, Cecile Chartier, Julie Nye, Steve Thorne, Tony Reid, Shaoheng Ni, Andre Lieber, Kerry Fisher, Len Seymour, Gabor M Rubanyi, Richard N Harkins, Terry W Hermiston
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2409 (2008)
BackgroundViral-mediated oncolysis is a novel cancer therapeutic approach with the potential to be more effective and less toxic than current therapies due to the agents selective growth and amplification in tumor cells. To date, these agents have be
Externí odkaz:
https://doaj.org/article/791544878a6041298c0ab175a5f83c9b
Publikováno v:
International Journal of Peptide and Protein Research. 8:125-130
We have computed the observed distribution of amino acid pairs n, n+1 up to n, n+10 within 100 unrelated protein sequences containing a total of 14,034 amino acids. The expected distribution of the same amino acid pairs was calculated assuming that t
Autor:
Richard N. Harkins, Fang Jin, Peter J. Kretschmer, Hu Sheng Qian, Paul Szymanski, Maxine Bauzon, Gabor M. Rubanyi, Terry Hermiston
Publikováno v:
Molecular Therapy. 15:1340-1347
We have developed a one-plasmid regulated gene expression system, pBRES, based on a mifepristone (MFP)-inducible two-plasmid system. The various expression elements of the pBRES system (promoters, 5′ and 3′ untranslated regions (UTRs), introns, t
Autor:
Gabor M. Rubanyi, Oliver Ast, Cynthia Gross, Husheng Qian, Linda Cashion, Richard N. Harkins, Maxine Bauzon, Alan R. Brooks, Caralee Schaefer, Paul Szymanski, Ann Orme, Harald Petry, Heather Gibson
Publikováno v:
Journal of Interferon & Cytokine Research. 26:699-705
Recombinant interferon-beta (IFN-beta) protein is used successfully for the treatment of multiple sclerosis (MS). Gene therapy might be an alternative approach to overcome drawbacks occurring with IFN-beta protein therapy. A critical issue in develop
Autor:
Cynthia Gross, Richard N. Harkins, Harald Petry, Perry Liu, Linda Cashion, Toni Rose Hidalgo, Hu Sheng Qian, Paul Szymanski, Alan R. Brooks, Claudia Goldman, Caralee Schaefer, Gabor M. Rubanyi, Peiyin Wang
Publikováno v:
Journal of Interferon & Cytokine Research. 26:449-454
Experimental allergic encephalomyelitis (EAE) is a model of central nervous system (CNS) inflammation that follows immunization with certain CNS antigens. The course and clinical manifestations of EAE are similar to those of multiple sclerosis (MS) i
Autor:
H S Qian, Katalin Kauser, Huw Ly, Cashion L, Liu P, Halks-Miller M, Dole Wp, Jun Yu, Hill Sm, Jin F, Blasko E, Richard N. Harkins, Vergona R, Peter J. Kretschmer, Gabor M. Rubanyi, P Szymanski, William C. Sessa, A Orme
Publikováno v:
Gene Therapy. 13:1342-1350
Gene delivery of angiogenic growth factors is a promising approach for the treatment of ischemic cardiovascular diseases. However, success of this new therapeutic principle is hindered by the lack of critical understanding as to how disease pathology
Autor:
Sarah Hale, C Herbert, Kerry D. Fisher, Karel Ulbrich, Vivien Mautner, A B Hale, Len Seymour, Terry Hermiston, N K Green, Richard N. Harkins
Publikováno v:
Gene Therapy. 11:1256-1263
Systemic delivery of adenoviral vectors is a major goal in cancer gene therapy, but is currently prohibited by rapid hepatic uptake of virus following intravenous injection with levels of viable virus in the murine plasma typically falling to less th
Autor:
Pengxuan Liu, Alan R. Brooks, Peiyin Wang, Gabor M. Rubanyi, Hu Sheng Qian, Richard N. Harkins
Publikováno v:
The Journal of Gene Medicine. 6:395-404
Background Although the transient nature of transgene expression using first-generation adenovirus (Ad) vectors is well known, the exact mechanisms responsible for this phenomenon are uncertain. Methods Rats were given intramuscular (i.m.) injections
Autor:
Campbell McInnes, David W. Hoyt, Richard N. Harkins, Brian D. Sykes, Maria T. Debanne, Rene N. Pagila, Maureen D. O'Connor-McCourt
Publikováno v:
Journal of Biological Chemistry. 271:32204-32211
The study of human transforming growth factor-α (TGF-α) in complex with the epidermal growth factor (EGF) receptor extracellular domain has been undertaken in order to generate information on the interactions of these molecules. Analysis of 1H NMR
Autor:
Robert T. Jensen, A de Weerth, Stephen A. Wank, Richard N. Harkins, Timothy Slattery, Hagit Shapira
Publikováno v:
Proceedings of the National Academy of Sciences. 89:3125-3129
The cholecystokinin (CCK) family of peptides and their receptors are widely distributed throughout the gastrointestinal and central nervous systems where they regulate secretion, motility, growth, anxiety, and satiety. The CCK receptors can be subdiv