Výsledky vyhledávání - "Richard N. Clayton"

Data from Genome-Wide Analysis in a Murine Dnmt1 Knockdown Model Identifies Epigenetically Silenced Genes in Primary Human Pituitary Tumors

Autor: William E. Farrell, Richard N. Clayton, Philip Whitby, Kate Revill, Kevin J. Dudley

DNA methylation at promoter CpG islands (CGI) is an epigenetic modification associated with inappropriate gene silencing in multiple tumor types. In the absence of a human pituitary tumor cell line, small interfering RNA–mediated knockdown of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56a78ac405b447c5e555ce511d08e13d
https://doi.org/10.1158/1541-7786.c.6541483

Zobrazit plný text záznamu

The role of cumulative growth hormone exposure in determining mortality and morbidity in acromegaly: a single centre study

Autor: Raoul C. Reulen, Lakshminarayanan Varadhan, Richard N. Clayton, Maureen Brown

Publikováno v: Pituitary. 19:251-261

Acromegaly has traditionally been associated with significant mortality and cardiovascular morbidity. The aim of this study was to assess the overall mortality and improvement in mortality and morbidity in acromegaly and correlate these with cumulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5e860b171ade8d74256f07eee58fb0
https://doi.org/10.1007/s11102-015-0700-3

Zobrazit plný text záznamu

Preincubation of Pituitary Tumor Cells With the Epidrugs Zebularine and Trichostatin A Are Permissive for Retinoic Acid-Augmented Expression of the BMP-4 and D2R Genes

Autor: Cuong V. Duong, Kiren Yacqub-Usman, William E. Farrell, Richard N. Clayton

Publikováno v: Endocrinology. 154:1711-1721

Retinoic acid (RA)-induced expression of bone morphogenetic protein-4 (BMP-4) inhibits in vitro and in vivo cell proliferation and ACTH synthesis in corticotroph-derived tumor cells. Reduced expression of BMP-4 in this adenoma subtype is associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeff5fac852700d5d0183f312a1f2864
https://doi.org/10.1210/en.2013-1061

Zobrazit plný text záznamu

The EFEMP1 Gene: A Frequent Target for Epigenetic Silencing in Multiple Human Pituitary Adenoma Subtypes

Autor: Kiren Yacqub-Usman, Cuong V. Duong, Richard D. Emes, Richard N. Clayton, William E. Farrell

Publikováno v: Neuroendocrinology. 98:200-211

Background/Aims: In a genome-wide investigation we recently identified the EGF-containing fibulin-like extracellular matrix protein 1 gene, EFEMP1, as hypermethylated in growth hormone-secreting adenoma. Methods: In an independent cohort we determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd6b63d3c2d4d0fee42ce32c662741a3
https://doi.org/10.1159/000355624

Zobrazit plný text záznamu

Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours

Autor: Rajesh V. Thakker, J L Magnay, John E. Bicknell, E Kyrodimou, David J. Simpson, William E. Farrell, Richard N. Clayton

Publikováno v: British Journal of Cancer

The majority of pituitary tumours are monoclonal in origin and arise sporadically or occasionally as part of multiple endocrine neoplasia type 1 (MEN1). Whilst a multi-step aetiology involving both oncogenes and tumour suppressor genes has been propo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f77bf2d3bd825eddc977c0df0da26ad
https://ora.ox.ac.uk/objects/uuid:c1361a17-cff5-4357-b751-f0b83260c347

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání