Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Richard N McLaughlin"'
Autor:
Michael J Xie, Gareth A Cromie, Katherine Owens, Martin S Timour, Michelle Tang, J Nathan Kutz, Ayman W El-Hattab, Richard N McLaughlin, Aimée M Dudley
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010972 (2023)
Reduced activity of the enzymes encoded by PHGDH, PSAT1, and PSPH causes a set of ultrarare, autosomal recessive diseases known as serine biosynthesis defects. These diseases present in a broad phenotypic spectrum: at the severe end is Neu-Laxova syn
Externí odkaz:
https://doaj.org/article/5cbfc7893cfb45d0b000a1426ef56261
Publikováno v:
eLife, Vol 9 (2020)
Host-virus arms races are inherently asymmetric; viruses evolve much more rapidly than host genomes. Thus, there is high interest in discovering mechanisms by which host genomes keep pace with rapidly evolving viruses. One family of restriction facto
Externí odkaz:
https://doaj.org/article/26f89791fb8e474ab2f7632f246e5d5c
Autor:
Rossana Colón-Thillet, Emily Hsieh, Laura Graf, Richard N McLaughlin, Janet M Young, Georg Kochs, Michael Emerman, Harmit S Malik
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000181 (2019)
Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenes
Externí odkaz:
https://doaj.org/article/17900a824db4486098fa966658ecc257
Autor:
Amit Sharma, Richard N McLaughlin, Ryan S Basom, Caroline Kikawa, Molly OhAinle, Jacob S Yount, Michael Emerman, Julie Overbaugh
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007925 (2019)
HIV-1 does not persistently infect macaques due in part to restriction by several macaque host factors. This has been partially circumvented by generating chimeric SIV/HIV-1 viruses (SHIVs) that encode SIV antagonist of known restriction factors. How
Externí odkaz:
https://doaj.org/article/1febe60de0c6484ba46e595b7a4da92a
Autor:
Richard N McLaughlin
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2005470 (2018)
Transposable elements comprise a huge portion of most animal genomes. Unlike many pathogens, these elements leave a mark of their impact via their insertion into host genomes. With proper teasing, these sequences can relay information about the evolu
Externí odkaz:
https://doaj.org/article/9a086640577b4c8093c66bfbd4ed1d61
Autor:
Richard N McLaughlin, Harmit S Malik
Publikováno v:
PLoS Genetics, Vol 11, Iss 7, p e1005364 (2015)
Externí odkaz:
https://doaj.org/article/2fb89e3eb32a41e594da5c04814667e4
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004531 (2014)
Mammalian genomes comprise many active and fossilized retroelements. The obligate requirement for retroelement integration affords host genomes an opportunity to 'domesticate' retroelement genes for their own purpose, leading to important innovations
Externí odkaz:
https://doaj.org/article/4afacfdc604f4ebc93bb57a368d2735d
Autor:
Michael J. Xie, Gareth A. Cromie, Katherine Owens, Martin S. Timour, Michelle Tang, J. Nathan Kutz, Ayman W. El-Hattab, Richard N. McLaughlin, Aimée M. Dudley
Publikováno v:
bioRxiv
BackgroundPathogenic variants inPHGDH, PSAT1, andPSPHcause a set of rare, autosomal recessive diseases known as serine biosynthesis defects. Serine biosynthesis defects present in a broad phenotypic spectrum that includes, at the severe end, Neu–La
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6546749b6c5e1e716fc5b17b1054840d
https://doi.org/10.1101/2023.01.11.523651
https://doi.org/10.1101/2023.01.11.523651
Autor:
Lei Yang, Genevieve A. Metzger, Ricky Padilla Del Valle, Diego Delgadillo Rubalcaba, Richard N. McLaughlin
Transposable elements including LINE-1 (Long INterspersed Element-1) impact genome variation, function, regulation, and disease. LINE-1s seem to have expanded as distinct consecutive lineages, but the drivers of lineage emergence and disappearance ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdf4d119c36403f2171dbf6dc12cd019
https://doi.org/10.1101/2022.11.17.516944
https://doi.org/10.1101/2022.11.17.516944
Publikováno v:
Science (New York, N.Y.). 378(6618)
The human genome contains a domesticated viral envelope gene with antiviral activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d21424800d06714ab40be94f6f7040e
https://pubmed.ncbi.nlm.nih.gov/36302021
https://pubmed.ncbi.nlm.nih.gov/36302021