Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Richard N Freiman"'
Autor:
Megan A Gura, Maria M Mikedis, Kimberly A Seymour, Dirk G de Rooij, David C Page, Richard N Freiman
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008515 (2020)
Germ cells undergo many developmental transitions before ultimately becoming either eggs or sperm, and during embryonic development these transitions include epigenetic reprogramming, quiescence, and meiosis. To begin understanding the transcriptiona
Externí odkaz:
https://doaj.org/article/621760bfc3a2474c9061383b9789fb7a
Autor:
Kathryn J Grive, Eric A Gustafson, Kimberly A Seymour, Melody Baddoo, Christoph Schorl, Kayla Golnoski, Aleksandar Rajkovic, Alexander S Brodsky, Richard N Freiman
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006128 (2016)
TAF4b is a gonadal-enriched subunit of the general transcription factor TFIID that is implicated in promoting healthy ovarian aging and female fertility in mice and humans. To further explore the potential mechanism of TAF4b in promoting ovarian foll
Externí odkaz:
https://doaj.org/article/f86c6d9be15841a8ba6bc4d56097c4f4
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
As ovarian tumors progress, they undergo a process of dedifferentiation, allowing adaptive changes in growth and morphology that promote metastasis and chemoresistance. Herein, we outline a hypothesis that TATA-box binding protein (TBP) associated fa
Externí odkaz:
https://doaj.org/article/10556480ee57440a9d429e83bb76ca83
Autor:
Megan A. Gura, Myles A. Bartholomew, Kimberly M. Abt, Soňa Relovská, Kimberly A. Seymour, Richard N. Freiman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Prospermatogonia (ProSpg) link the embryonic development of male primordial germ cells to the healthy establishment of postnatal spermatogonia and spermatogonial stem cells. While these spermatogenic precursor cells undergo the characteristic transit
Externí odkaz:
https://doaj.org/article/3597998ca5324d9fbdb6b4ea2adaa104
Supplementary Figure 1. Reduction in Notch1 levels did not alter levels of col4α2 expression. Supplementary Table 1. List of Antibodies. Supplementary Table 2. List of Primers. Supplementary Table 3. Increased Notch3 expression correlates with incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0c984078a7aa091c12f04de3112ceb
https://doi.org/10.1158/1541-7786.22511376
https://doi.org/10.1158/1541-7786.22511376
Supplementary Figure/Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6286ed41734087843bd700fe5997953c
https://doi.org/10.1158/1541-7786.22511373
https://doi.org/10.1158/1541-7786.22511373
Ovarian cancer is a lethal disease with the majority of diagnosed women having distant metastases. Interestingly, although Notch3 overexpression has been correlated with poor survival in epithelial ovarian cancer (EOC), little is known about its mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c41807403bf0f3b0c4d548d590d50c
https://doi.org/10.1158/1541-7786.c.6539928.v1
https://doi.org/10.1158/1541-7786.c.6539928.v1
Autor:
Megan A. Gura, Myles A. Bartholomew, Kimberly M. Abt, Soňa Relovská, Kimberly A. Seymour, Richard N. Freiman
Prospermatogonia (ProSpg) link the embryonic development of male primordial germ cells to the healthy establishment of postnatal spermatogonia and long-term mammalian spermatogenesis. While these spermatogenic precursor cells undergo the characterist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f14f1fe8f2e3ff86f8acc05f685124c6
https://doi.org/10.1101/2022.04.20.488869
https://doi.org/10.1101/2022.04.20.488869
Publikováno v:
Medical oncology (Northwood, London, England). 39(5)
Human epididymis protein-4 (HE4/WFDC2) has been well-studied as an ovarian cancer clinical biomarker. To improve our understanding of its functional role in high grade serous ovarian cancer, we determined transcriptomic differences between ovarian tu
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The development of multicellular organisms and the uniqueness of each cell are achieved by distinct transcriptional programs. Multiple processes that regulate gene expression converge at the core promoter region, an 80 bp region that directs accurate