Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Richard Meldau"'
Autor:
Michele Tomasicchio, Jason Limberis, Ruben van der Merwe, Rachael Jacobson, Richard Meldau, Grant Theron, Mark Nicol, Rob Warren, Keertan Dheda
Publikováno v:
International Journal of Infectious Diseases, Vol 96, Iss , Pp 240-243 (2020)
Objectives: Between-person variability in T-cell-specific interferon-gamma release assay (IGRA) responses and discordance between IGRA test formats are poorly understood. Methods: We evaluated the IFN-γ responses (QuantiFERON-TB Gold-In-Tube [QFT-GI
Externí odkaz:
https://doaj.org/article/3fc580e54caa40a8b0014d235b1f7996
Publikováno v:
International Journal of Infectious Diseases, Vol 95, Iss , Pp 246-252 (2020)
Background: There are limited data about Xpert-Ultra performance in different settings, in HIV-infected persons, in those with a history of previous TB, and with trace readouts. Methods: We evaluated the relative accuracy of Xpert-MTB/RIF and Xpert-U
Externí odkaz:
https://doaj.org/article/379251ab73c6482f8b3f319d10dabab3
Autor:
Phindile Gina, Philippa J. Randall, Tapuwa E. Muchinga, Anil Pooran, Richard Meldau, Jonny G. Peter, Keertan Dheda
Publikováno v:
BMC Infectious Diseases, Vol 17, Iss 1, Pp 1-6 (2017)
Abstract Background Urine LAM testing has been approved by the WHO for use in hospitalised patients with advanced immunosuppression. However, sensitivity remains suboptimal. We therefore examined the incremental diagnostic sensitivity of early mornin
Externí odkaz:
https://doaj.org/article/12cad1d2e2654b17af460d0d6e368772
Autor:
Lucy C K Bell, Gabriele Pollara, Mellissa Pascoe, Gillian S Tomlinson, Rannakoe J Lehloenya, Jennifer Roe, Richard Meldau, Robert F Miller, Alan Ramsay, Benjamin M Chain, Keertan Dheda, Mahdad Noursadeghi
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005469 (2016)
Increased risk of tuberculosis (TB) associated with HIV-1 infection is primarily attributed to deficient T helper (Th)1 immune responses, but most people with active TB have robust Th1 responses, indicating that these are not sufficient to protect ag
Externí odkaz:
https://doaj.org/article/2756ecfddd6448d2884a1415dc005b6c
Autor:
Grant Theron, Jonny Peter, Laura Lenders, Richard van Zyl-Smit, Richard Meldau, Ureshnie Govender, Keertan Dheda
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37436 (2012)
Measures of bacillary load in patients with tuberculosis (TB) may be useful for predicting and monitoring response to treatment. The relationship between quantitative T-cell responses and mycobacterial load remains unclear. We hypothesised that, in a
Externí odkaz:
https://doaj.org/article/af9b66401481407caac9735a08b0315f
Autor:
Richard N van Zyl-Smit, Anke Binder, Richard Meldau, Hridesh Mishra, Patricia L Semple, Grant Theron, Jonathan Peter, Andrew Whitelaw, Suren K Sharma, Robin Warren, Eric D Bateman, Keertan Dheda
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28815 (2011)
Accurate quantification of mycobacterial load is important for the evaluation of patient infectiousness, disease severity and monitoring treatment response in human and in-vitro laboratory models of disease. We hypothesized that newer techniques woul
Externí odkaz:
https://doaj.org/article/abeeb7a6f9064f2ea826e26281cabeea
Autor:
Tamaryn J Cashmore, Jonathan G Peter, Richard N van Zyl-Smit, Patricia L Semple, Alice Maredza, Richard Meldau, Alimuddin Zumla, Barbara Nurse, Keertan Dheda
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10389 (2010)
The diagnosis of smear-negative or sputum-scarce tuberculosis (TB) is problematic as culture takes several weeks and representative biological samples are difficult to obtain. RD-1 antigen-specific interferon-gamma release assays (IGRAs) are sensitiv
Externí odkaz:
https://doaj.org/article/4ae582f9b83a4717835bb1cd96a8672f
Autor:
Keertan Dheda, Virginia Davids, Laura Lenders, Teri Roberts, Richard Meldau, Daphne Ling, Laurence Brunet, Richard van Zyl Smit, Jonathan Peter, Clare Green, Motasim Badri, Leonardo Sechi, Surendra Sharma, Michael Hoelscher, Rodney Dawson, Andrew Whitelaw, Jonathan Blackburn, Madhukar Pai, Alimuddin Zumla
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9848 (2010)
The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB(R)-ELISA) may have some utility for the diagnosis of TB in H
Externí odkaz:
https://doaj.org/article/670128ab3cc74ad0ba8b1ed316592365
Autor:
Keertan Dheda, Richard N Van-Zyl Smit, Leonardo A Sechi, Motasim Badri, Richard Meldau, Gregory Symons, Hoosein Khalfey, Igshaan Carr, Alice Maredza, Rodney Dawson, Helen Wainright, Andrew Whitelaw, Eric D Bateman, Alimuddin Zumla
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4689 (2009)
BackgroundCurrent tools for the diagnosis of tuberculosis pleural effusions are sub-optimal. Data about the value of new diagnostic technologies are limited, particularly, in high burden settings. Preliminary case control studies have identified IFN-
Externí odkaz:
https://doaj.org/article/baa4d0fe7fd24b198853321c1f77e24b
Autor:
Aliasgar Esmail, Philippa Randall, Suzette Oelofse, Michele Tomasicchio, Anil Pooran, Richard Meldau, Edson Makambwa, Lynelle Mottay, Shameem Jaumdally, Gregory Calligaro, Stuart Meier, Marianna de Kock, Tawanda Gumbo, Robin Mark Warren, Keertan Dheda
Publikováno v:
Nature Medicine. 29:1009-1016