Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Richard M. Wright"'
Autor:
Mehdi A. Fini, Miguel A. Lanaspa, Eric A. Gaucher, Brian Boutwell, Takahiko Nakagawa, Richard M. Wright, Laura G. Sanchez-Lozada, Peter Andrews, Kurt R. Stenmark, Richard J. Johnson
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-5 (2021)
Abstract Background Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to mitochondria and to
Externí odkaz:
https://doaj.org/article/6cf8865c41f7429f8e6c8c278ac69c75
Autor:
Miguel A. Lanaspa, Peter Andrews, Richard M. Wright, Richard J. Johnson, Kurt R. Stenmark, Brian B. Boutwell, Mehdi A. Fini, Takahiko Nakagawa, Eric A. Gaucher, Laura G. Sánchez-Lozada
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-5 (2021)
Cancer & Metabolism
Cancer & Metabolism
Background Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to mitochondria and to reduce ad
Publikováno v:
Clinical and Translational Medicine, Vol 1, Iss 1, Pp n/a-n/a (2012)
Abstract Two risk factors for the development and progression of cancers that are amenable to life style modification are chronic inflammation and the metabolic syndrome. This review proposes two new targets that may mechanistically integrate inflamm
Externí odkaz:
https://doaj.org/article/fd9f1564212245e0879e1251e31e3868
Autor:
David J. Orlicky, Monika Dzieciatkowska, Jenifer Monks, James L. McManaman, Richard M. Wright, Elise S. Bales
Publikováno v:
The Journal of Physiology. 594:5899-5921
Key points Xanthine oxidoreductase (XOR) modulates milk lipid secretion and lactation initiation. XOR is required for butyrophilin1a1 clustering in the membrane during milk lipid secretion. XOR mediates apical membrane reorganization during milk lipi
Autor:
Gisela M. Vaitaitis, John E. Repine, Thomas B. Repine, L. K. Weigel, James L. McManaman, Richard M. Wright
Publikováno v:
Redox report : communications in free radical research. 1(5)
Denver, Tokyo, and Salt Lake City investigators recently published different complimentary deoxyribonucleic acid (cDNA) sequences for human liver xanthine dehydrogenase/xanthine oxidase (XD/XO). The gene encoding the Denver cDNA was subsequently link
Autor:
Richard M. Wright, Mari E. Weyman, Mehdi A. Fini, Gayle N. Shibao, Hillary Fitzgerald, Nancy D. Elkins, Janice Tiao, Sophie Gibbings
Publikováno v:
Gibbings, S, Elkins, N D, Fitzgerald, H, Tiao, J, Weyman, M E, Shibao, G, Fini, M A & Wright, R M 2011, ' Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1 alpha ', Journal of Biological Chemistry, vol. 286, no. 2, pp. 961-975 . https://doi.org/10.1074/jbc.M110.150847
The protective effects of pharmacological inhibitors of xanthine oxidoreductase (XOR) have implicated XOR in many inflammatory diseases. Nonetheless, the role played by XOR during inflammation is poorly understood. We previously observed that inhibit
α-4/β-1 and α-L/β-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury
Publikováno v:
British Journal of Pharmacology. 152:915-929
Background and purpose: Injury to the alveolar epithelium is a critical feature of acute lung injury (ALI). Using a cytokine model of ALI we demonstrated previously that newly recruited mononuclear phagocytes (MNP) contributed to lung inflammation an
Autor:
Noi Kosila, Richard M. Wright, Brendan Essary, James L. McManaman, Lisa A. Ginger, John E. Repine, Nancy D. Elkins
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 30:479-490
Acute lung injury (ALI) is characterized by increased alveolar cytokines, inflammatory cell infiltration, oxidative stress, and alveolar cell apoptosis. Previous work suggested that xanthine oxidoreductase (XOR) may contribute to oxidative stress in
Publikováno v:
Inflammation. 27:257-263
For unknown reasons, serum ferritin levels increase in patients at risk for and with acute lung injury (ALI). To improve understanding of the relationship between serum ferritin alterations and the development of ALI, we investigated the effect of ir
Publikováno v:
The Journal of Physiology. 545:567-579
Xanthine oxidoreductase (XOR), a key enzyme of purine metabolism, has been implicated in the secretion of the milk fat droplet in lactating mammary epithelial cells, possibly through structural interactions with other milk fat globule proteins includ