Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Richard M. Torack"'
Publikováno v:
Neuropathology and Applied Neurobiology. 27:444-450
Hippocampal deafferentation has been proposed as a pathogenetic mechanism for neurofibrillary tangle (NFT) formation in human mesolimbocortical dementia. We previously developed a rodent model of hippocampal deafferentation involving bilateral destru
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 55:466-470
This work tests the hypothesis that deafferentation caused by experimental brain lesions leads to the appearance of perikaryal argyrophilia and the accumulation of phosphorylated cytoskeletal proteins which are potential precursors for neurofibrillar
Autor:
John W. Miller, Richard M. Torack
Publikováno v:
Brain research. 669(1)
This study demonstrates that combined dopaminergic and cholinergic denervation of the hippocampus results in the appearance of morphologically altered, Tau reactive, apical dendrites of granule cells in the rat dentate gyrus. The denervated granule c
Autor:
Richard M. Torack, John W. Miller
Publikováno v:
Brain research. 574(1-2)
The occurrence of neurofibrillary tangles (NFT) in the perforant pathway in association with dopaminergic cell loss in the ventral tegmental area (VTA) in human mesolimbic dementia, raises the possibility that denervation is a cause of NFT formation.
Autor:
John C. Morris, Richard M. Torack
Publikováno v:
Neuroscience letters. 116(1-2)
A practical methodology has been described for the use of human postmortem brain tissue in both tyrosine hydroxylase and dopamine β-hydroxylase immunohistochemistry in which in situ perfusion with paraformaldehyde is followed by immersion fixation i
Publikováno v:
Annals of Neurology. 24:17-22
Clinical investigations of Alzheimer's disease (AD) have been limited by diagnostic inaccuracy. We employed explicit clinical inclusion and exclusion criteria to identify subjects with senile dementia of the Alzheimer type (SDAT). In a consecutive se
Autor:
Richard M. Torack
Publikováno v:
Neuroscience Letters. 71:365-369
T-lymphocyte function in Alzheimer's disease (AS) was evaluated by means of delayed type hypersensitivity (DTH) and mitogen responsiveness using concanavalin A (Con A) and BCG vaccine as stimulators. DTH and the response to Con A was significantly lo
Autor:
Richard M. Torack
Publikováno v:
Computerized Radiology. 6:35-41
An index case and 13 other cases of acute ischemic cerebral infarction have been examined following the occurrence of death 1–6 days postictus. Histologic studies and water content assay involved both the infarct and peri-infarct tissue. The primar
Autor:
Richard M. Torack
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 41:387-390
Autor:
Richard M. Torack, Mary-Elizabeth Lell, Barry A. Hendin, Abdelsalam H. Ragab, Darryl C. DeVivo, Teresa J. Vietti
Publikováno v:
Cancer. 33:468-482
A 7-year-old boy with acute lymphocytic leukemia suffered increasing dementia, seizures, ataxia, and spasticity. The neuropathologic findings appeared unique, and included extensive fibrillary gliosis, with lesser degrees of myelin loss and axonal dy