An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial

Autor: Adam D. DeZure, Emily E. Coates, Zonghui Hu, Galina V. Yamshchikov, Kathryn L. Zephir, Mary E. Enama, Sarah H. Plummer, Ingelise J. Gordon, Florence Kaltovich, Sarah Andrews, Adrian McDermott, Michelle C. Crank, Richard A Koup, Richard M. Schwartz, Robert T. Bailer, Xiangjie Sun, John R. Mascola, Terrence M. Tumpey, Barney S. Graham, Julie E. Ledgerwood

Publikováno v: npj Vaccines, Vol 2, Iss 1, Pp 1-6 (2017)

Avian influenza: A vaccine for a deadly emergent strain A vaccine candidate to treat a deadly subtype of avian influenza was shown to induce protective antibodies in initial clinical trials. As of March 2017, avian influenza strain A/H7N9 has killed

Externí odkaz: https://doaj.org/article/e2d2da024d7c4739ac5a7e10fb271246

Safety, tolerability, and immunogenicity of the respiratory syncytial virus prefusion F subunit vaccine DS-Cav1: a phase 1, randomised, open-label, dose-escalation clinical trial

Autor: Peifeng Chen, Anita Arthur, Kaitlyn M. Morabito, Kristin Leach, Xiaolin Wang, Grace L. Chen, Attila Nagy, Lauren A. Chang, Jon Cooper, Amy L. Chamberlain, Janel Holland-Linn, Olga Vasilenko, Alicia T. Widge, Shufeng Bai, Judith A Stein, LaSonji A. Holman, Cristina Carter, Iris Pittman, Deepika Gollapudi, Lisa A. Kueltzo, Colleen Fridley, Michelle C. Crank, Amritha Menon, William Whalen, Mridul Ghosh, Cynthia S. Hendel, Martha Nason, Amy Liu, Althaf Hussain, Laura Novik, Pernell Williams, Maria Burgos Florez, Robert T. Bailer, Thuy Nguyen, Brenda Larkin, Tracy J. Ruckwardt, Pamela Costner, Lam Le, Zhong Zhao, Elizabeth Carey, Vera Ivleva, Jennifer Walters, John R. Mascola, Jennifer Cunningham, Olga Trofymenko, Ya-chen Chang, Somia P. Hickman, Martin R. Gaudinski, Richard M. Schwartz, Slobodanka D. Manceva, Kevin Carlton, Barney S. Graham, Rahul Ragunathan, Jason G. D. Gall, Ana M. Ortega-Villa, Colin Tran, Sarah H. Plummer, Abidemi Ola, Ro Shauna S Rothwell, Ingelise J. Gordon, Mingzhong Chen, Jamie G. Saunders, Aba Mensima Eshun, Bob C. Lin, Azad Kumar, Nina M. Berkowitz, Xun Liu, Cora Trelles Cartagena, Emily Phung, Galina Yamshchikov, Joe Horwitz, Sarah O’Connell, Florence Kaltovich, Floreliz Mendoza, LaShawn Requilman, Man Chen, Preeti Apte, Christopher Lee, Renunda Hicks

Publikováno v: Lancet Respir Med

Multiple active vaccination approaches have proven ineffective in reducing the substantial morbidity and mortality caused by respiratory syncytial virus (RSV) in infants and older adults (aged ≥65 years). A vaccine conferring a substantial and sust

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ae60b574c97c5be6e3eabd0b1e70f3
https://doi.org/10.1016/s2213-2600(21)00098-9

Structural Characterization and Formulation Development of a Trivalent Equine Encephalitis Virus-Like Particle Vaccine Candidate

Autor: Richard M. Schwartz, Newton Wahome, Sangeeta B. Joshi, Harshit Khasa, David B. Volkin, C. Russell Middaugh, Vishal M. Toprani, Lisa A. Kueltzo, Yuan Cheng

Publikováno v: Journal of Pharmaceutical Sciences. 107:2544-2558

The zoonotic equine encephalitis viruses (EEVs) can cause debilitating and life-threatening disease, leading to ongoing vaccine development efforts for an effective virus-like particle (VLP) vaccine based on 3 strains of EEV (Eastern, Western, and Ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d757730dc5f561f33ebbdb0989427d5a
https://doi.org/10.1016/j.xphs.2018.05.022

Development and Application of Synthetic Affinity Ligands for the Purification of Ferritin-Based Influenza Antigens

Autor: Shaleem I. Jacob, Richard M. Schwartz, Nick Bampos, Basmah Khogeer, Tom D. Sheppard, Christopher R. Lowe

Publikováno v: Bioconjugate Chemistry. 28:1931-1943

A recently developed novel recombinant influenza antigen vaccine has shown great success in preclinical studies in ferrets and mice. It provides broader protection, and is efficient to manufacture compared to the conventional trivalent influenza vacc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4141b3e46b0bac49960ee755c17ab6a5
https://doi.org/10.1021/acs.bioconjchem.7b00253

The transient expression of CHIKV VLP in large stirred tank bioreactors

Autor: Frank J. Arnold, Peifeng Chen, Vera B. Ivleva, Jacob Demirji, Richard M. Schwartz, Joe Horwitz

Publikováno v: Cytotechnology

Transient gene expression (TGE) bioprocesses have been difficult to scale up in large stirred tank bioreactors with volumes of more than 1.5 L. Low production levels are often observed, but the causes have not been investigated (Gutierrez-Granados et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d586129ded11f024afbdd0b452ad466
https://europepmc.org/articles/PMC6874627/