Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Richard M. Reznick"'
Autor:
Varman T. Samuel, Richard M. Reznick, William M. Philbrick, Saki Sono, David Sebastián, Gerald I. Shulman, Morris F. White, Irene K. Moore, Yoshio Nagai, Katsutaro Morino, Susanne Neschen, Dimitrios N. Tsirigotis, Stefan Bilz
Publikováno v:
Diabetes
OBJECTIVE—Insulin resistance in skeletal muscle plays a critical role in the pathogenesis of type 2 diabetes, yet the cellular mechanisms responsible for insulin resistance are poorly understood. In this study, we examine the role of serine phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9ef3dc14461f035340c6e582dcefe3
http://europepmc.org/articles/PMC2551673
http://europepmc.org/articles/PMC2551673
Autor:
Gerald I. Shulman, Roberto Codella, Gary W. Cline, Ameya Kulkarni, Yu-Jin Hwang, Richard M. Reznick, Dongyan Zhang, Cheol Soo Choi, Zhen-Xiang Liu, Lutfi Abu-Elheiga, Alberto Distefano, David B. Savage, Sheene Kim, Salih J. Wakil
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16480-16485
Acetyl–CoA carboxylase 2 (ACC)2 is a key regulator of mitochondrial fat oxidation. To examine the impact of ACC2 deletion on whole-body energy metabolism, we measured changes in substrate oxidation and total energy expenditure in Acc2 −/− and W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc77b6883cc038ba337fac25f867a69
https://doi.org/10.1073/pnas.0706794104
https://doi.org/10.1073/pnas.0706794104
Autor:
Gerald I. Shulman, Marc Pypaert, Irene K. Moore, Ji Li, Simon A. Hawley, Douglas E. Befroy, Katsutaro Morino, Haihong Zong, Hannah J. Yu, Zhen Xiang Liu, Jianying Dong, Kirsty J. Mustard, Lawrence H. Young, D. Grahame Hardie, Richard M. Reznick
Publikováno v:
Cell Metabolism
Recent studies have demonstrated a strong relationship between aging-associated reductions in mitochondrial function, dysregulated intracellular lipid metabolism, and insulin resistance. Given the important role of the AMP-activated protein kinase (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983b365592b8f78eec6ea4f1782c43f7
https://doi.org/10.1016/j.cmet.2007.01.008
https://doi.org/10.1016/j.cmet.2007.01.008
Autor:
Gerald I. Shulman, Richard M. Reznick
Publikováno v:
The Journal of Physiology. 574:33-39
While it has been known for more than 75 years that physical activity is associated with increased mitochondrial content in muscle, the molecular mechanism for this adaptive process has only recently been elucidated. This brief review examines existi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aac9143f7fcb7402c12392323d22d75c
https://doi.org/10.1113/jphysiol.2006.109512
https://doi.org/10.1113/jphysiol.2006.109512
Autor:
Marcus P. Cooper, Saverio Cinti, Monia Manieri, Melina C. Fan, Mi X. Donovan, Katrin S. Lindenberg, Dimitri Krainc, Lindsay M. Rohas, Sibylle Jäger, Pei Hsuan Wu, Jiandie D. Lin, Vamsi K. Mootha, Chen-Yu Zhang, Ann Marie Zavacki, Bradford B. Lowell, Paul T. Tarr, Richard M. Reznick, Julie St-Pierre, Claudia R. Vianna, Bruce M. Spiegelman, Libin Cui, Zhidan Wu, Gerald I. Shulman
Publikováno v:
Cell. 119:121-135
PGC-1alpha is a coactivator of nuclear receptors and other transcription factors that regulates several metabolic processes, including mitochondrial biogenesis and respiration, hepatic gluconeogenesis, and muscle fiber-type switching. We show here th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903cc67efc88f3366a376cfa1382ef19
https://doi.org/10.1016/j.cell.2004.09.013
https://doi.org/10.1016/j.cell.2004.09.013
Autor:
Christoph Handschin, Cheol Soo Choi, Gary W. Cline, Yu-Jin Hwang, Richard M. Reznick, Dongyan Zhang, Zhen-Xiang Liu, Varman T. Samuel, Bruce M. Spiegelman, Alberto Distefano, Hui-Young Lee, Jiandie D. Lin, Roberto Codella, Kitt Falk Petersen, Douglas E. Befroy, Gerald I. Shulman, Sheene Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(50)
Peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α has been shown to play critical roles in regulating mitochondria biogenesis, respiration, and muscle oxidative phenotype. Furthermore, reductions in the expression of PGC-1α in musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076bd69cd33a5916cf19c64b099059dc
https://pubmed.ncbi.nlm.nih.gov/19066218
https://pubmed.ncbi.nlm.nih.gov/19066218
Autor:
Richard M, Reznick, Gerald I, Shulman
Publikováno v:
The Journal of physiology. 574(Pt 1)
While it has been known for more than 75 years that physical activity is associated with increased mitochondrial content in muscle, the molecular mechanism for this adaptive process has only recently been elucidated. This brief review examines existi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d97492d28808e7b87a6c0111438e64e
https://pubmed.ncbi.nlm.nih.gov/16709637
https://pubmed.ncbi.nlm.nih.gov/16709637
Autor:
Alberto Distefano, Ameya Kulkarni, Richard M. Reznick, Jonathan J. Fillmore, Yan Chen, Sheene Kim, Jason K. Kim, Gerald I. Shulman, Emily F. Collier, Irene K. Moore, Mario Kahn, Takamasa Higashimori, Cheol Soo Choi, Zhen-Xiang Liu, Yu-Jin Hwang, Chunli Yu
Publikováno v:
The Journal of clinical investigation. 117(7)
Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity. Increased concentrations of intracellular fatty acid metabolites have been postulated to interfere with insulin signaling by activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed7cb3a015e2604cf0e1530264c01c4
https://pubmed.ncbi.nlm.nih.gov/17571165
https://pubmed.ncbi.nlm.nih.gov/17571165