Zobrazeno 1 - 10
of 539
pro vyhledávání: '"Richard M. Ransohoff"'
Autor:
Stefano Garofalo, Germana Cocozza, Alessandro Mormino, Giovanni Bernardini, Eleonora Russo, Donald Ielpo, Diego Andolina, Rossella Ventura, Katiuscia Martinello, Massimiliano Renzi, Sergio Fucile, Mattia Laffranchi, Eva Piano Mortari, Rita Carsetti, Giuseppe Sciumè, Silvano Sozzani, Angela Santoni, Marie-Eve Tremblay, Richard M. Ransohoff, Cristina Limatola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of ad
Externí odkaz:
https://doaj.org/article/0211a315673a47ed8fe4e14ffd46fcd7
Autor:
Kaira A. Church, Derek Rodriguez, Andrew S. Mendiola, Difernando Vanegas, Irene L. Gutierrez, Ian Tamayo, Abdul Amadu, Priscila Velazquez, Sandra M. Cardona, Stefka Gyoneva, Anne C. Cotleur, Richard M. Ransohoff, Tejbeer Kaur, Astrid E. Cardona
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Diabetic retinopathy, a microvascular disease characterized by irreparable vascular damage, neurodegeneration and neuroinflammation, is a leading complication of diabetes mellitus. There is no cure for DR, and medical interventions marginally slow th
Externí odkaz:
https://doaj.org/article/2061e61566104f23b60844866d5b9d5b
Autor:
Atsuko Katsumoto, Olga N. Kokiko-Cochran, Shane M. Bemiller, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Traumatic brain injury (TBI) promotes several Alzheimer’s disease-like pathological features, including microtubule-associated protein tau (MAPT) accumulation within neurons. Macrophage activation in the injured hTau mouse model of tauopathy raises
Externí odkaz:
https://doaj.org/article/f41f39b5aae446be84a8a2be7d736220
Autor:
Mandana Hunter, Krista J. Spiller, Myrna A. Dominique, Hong Xu, Francis W. Hunter, Terry C. Fang, Rebecca G. Canter, Christopher J. Roberts, Richard M. Ransohoff, John Q. Trojanowski, Virginia M.-Y. Lee
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract The microglial reaction is a hallmark of neurodegenerative conditions, and elements thereof may exert differential effects on disease progression, either worsening or ameliorating severity. In amyotrophic lateral sclerosis (ALS), a syndrome
Externí odkaz:
https://doaj.org/article/f1e0fa8cb34c47c4962e39499fbefb6f
Autor:
Stefano Garofalo, Germana Cocozza, Alessandra Porzia, Maurizio Inghilleri, Marcello Raspa, Ferdinando Scavizzi, Eleonora Aronica, Giovanni Bernardini, Ling Peng, Richard M. Ransohoff, Angela Santoni, Cristina Limatola
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Neuroimmune interactions are important in amyotrophic lateral sclerosis (ALS). Here the authors characterize the role of NK cells in mouse models of ALS, and in patient tissue.
Externí odkaz:
https://doaj.org/article/ce9bca4a171342b9b49767f339053fb0
Autor:
Alex R. D. Delbridge, Dann Huh, Margot Brickelmaier, Jeremy C. Burns, Chris Roberts, Ravi Challa, Naideline Raymond, Patrick Cullen, Thomas M. Carlile, Katelin A. Ennis, Mei Liu, Chao Sun, Normand E. Allaire, Marianna Foos, Hui-Hsin Tsai, Nathalie Franchimont, Richard M. Ransohoff, Cherie Butts, Michael Mingueneau
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Microglia are central nervous system (CNS) resident immune cells that have been implicated in neuroinflammatory pathogenesis of a variety of neurological conditions. Their manifold context-dependent contributions to neuroinflammation are only beginni
Externí odkaz:
https://doaj.org/article/366580e0c4aa470182ab0d8f5cdc3740
Autor:
Agata Matejuk, Richard M. Ransohoff
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Based on discoveries enabled by new technologies and analysis using novel computational tools, neuroscience can be re-conceived in terms of information exchange in dense networks of intercellular connections rather than in the context of individual p
Externí odkaz:
https://doaj.org/article/ad36e42917d7421aa31296d2b6222e3b
Autor:
Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-de Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, Vincent Cirotteau, Mira Tohme, Allen Beke, Michaël Trichet, Virginie Bazin, Bobby N. Trawick, Richard M. Ransohoff, François Tronche, Bénédicte Manoury, Sheela Vyas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Inflammation is a component of Parkinson’s disease. Here the authors show that activation of Toll-like receptor 9 controlled by microglial glucocorticoid receptor signaling, contributes to dopamine neuron loss in a model of Parkinson’s disease.
Externí odkaz:
https://doaj.org/article/7e620af317d44ae895a31e6a05dc755b
Autor:
Paul J. Cheng-Hathaway, Erin G. Reed-Geaghan, Taylor R. Jay, Brad T. Casali, Shane M. Bemiller, Shweta S. Puntambekar, Victoria E. von Saucken, Roxanne Y. Williams, J. Colleen Karlo, Miguel Moutinho, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb, Gary E. Landreth
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-12 (2018)
Abstract Background The R47H variant of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) confers greatly increased risk for Alzheimer’s disease (AD), reflective of a central role for myeloid cells in neurodegeneration. Understanding how thi
Externí odkaz:
https://doaj.org/article/9cef465d893a4cad96b02dbb1853282c
Autor:
Karol Estrada, Christopher W. Whelan, Fengmei Zhao, Paola Bronson, Robert E. Handsaker, Chao Sun, John P. Carulli, Tim Harris, Richard M. Ransohoff, Steven A. McCarroll, Aaron G. Day-Williams, Benjamin M. Greenberg, Daniel G. MacArthur
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Neuromyelitis optica (NMO) is a rare autoimmune condition characterized by inflammation and demyelination of the optic nerve and the spinal cord. Here, Estrada et al. identify NMO susceptibility variants in the MHC region and find that autoantibody-p
Externí odkaz:
https://doaj.org/article/097b3f04c35840e1a363fdf27d852415