Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Richard M. Philpot"'
Publikováno v:
Archives of Biochemistry and Biophysics. 367:322-332
Methionine has previously been shown to be S-oxidized by flavin-containing monooxygenase (FMO) forms 1, 2, and 3. The most efficient catalyst was FMO3, which has a Km value for methionine S-oxidation of approximately 4 mM, and exhibits high selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1701ee6cd18e4976dd93f92a4f1c64e
https://doi.org/10.1006/abbi.1999.1247
https://doi.org/10.1006/abbi.1999.1247
Autor:
Kiyoshi Itagaki, Allan E. Rettie, Richard M. Philpot, Dieter H. Lang, Catherine Ibarra, Catherine K. Yeung, Raimund M. Peter, Rodolfo Gasser
Publikováno v:
Biochemical Pharmacology. 56:1005-1012
In the present study, we expressed human flavin-containing monooxygenase 1 (FMO1), FMO3, FMO4t (truncated), and FMO5 in the baculovirus expression vector system at levels of 0.6 to 2.4 nmol FMO/mg of membrane protein. These four isoforms, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61259dd8040073351ee00655a40dfad2
https://doi.org/10.1016/s0006-2952(98)00218-4
https://doi.org/10.1016/s0006-2952(98)00218-4
Publikováno v:
Archives of Biochemistry and Biophysics. 358:92-97
Human flavin-containing monooxygenase 3 (FMO3) is subject to modulation by tricyclic antidepressants and other agents. Imipramine activates FMO3-catalyzed metabolism of methimazole at all substrate concentrations tested. This distinguishes FMO3 from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5379f92b746d8c7ddf7da91164f83a8b
https://doi.org/10.1006/abbi.1998.0835
https://doi.org/10.1006/abbi.1998.0835
Publikováno v:
Biochemistry. 37:5930-5938
The activity of the flavin-containing monooxygenase (FMO) can be modulated by a number of nitrogen-containing compounds in a manner that is both isoform and modulator-dependent. We now show that the direction (activation or inhibition) and extent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea7c2bc5a36950b45329d99f8bd06a7
https://doi.org/10.1021/bi972622b
https://doi.org/10.1021/bi972622b
Autor:
Randy L. Rose, Ernest Hodgson, Nathan J. Cherrington, Richard M. Philpot, Kieran M. Clements, Patricia E. Levi, J. Greg Falls
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 12:205-212
Full-length cDNA clones encoding FMO1 and FMO5 have been isolated from a library constructed with mRNA from the liver of a female CD-1 mouse. The derived sequence of FMO1 contains 2310 bases: 1596 in the coding region, 301 in the 5'-flanking region,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839bb4aff7a4e522094b33df534e64e6
https://doi.org/10.1002/(sici)1099-0461(1998)12:4<205::aid-jbt2>3.0.co
https://doi.org/10.1002/(sici)1099-0461(1998)12:4<205::aid-jbt2>3.0.co
Autor:
Charles G. Plopper, Richard M. Philpot, Mary E. Murphy, Alan R. Buckpitt, Michelle V. Fanucchi
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 17:302-314
Various studies indicate that cytodifferentiation of Clara cells and development of pulmonary cytochrome P450 (CYP) monooxygenases occur postnatally. The timing of these events is species-specific. Neonatal mice are more susceptible than adult mice a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebd4052b7f895472b9e30db21e3c662
https://doi.org/10.1165/ajrcmb.17.3.2774
https://doi.org/10.1165/ajrcmb.17.3.2774
Autor:
Adnan A. Elfarra, Sharon L. Ripp, Renee J. Krause, Richard M. Philpot, Peter J. Sausen, Lila H. Overby
Publikováno v:
Archives of Biochemistry and Biophysics. 333:109-116
Methionine is oxidized to methionine sulfoxide by rat liver and kidney microsomes in an O2- and NADPH-dependent manner. In all microsomal assays, no methionine sulfone was detected. Use of a monoclonal antibody to rat liver cytochrome P-450 reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fb309b67b460e472ba379a9aa76682
https://doi.org/10.1006/abbi.1996.0370
https://doi.org/10.1006/abbi.1996.0370
Publikováno v:
Biochemical Pharmacology. 50:1567-1575
In the present study, retroviral vectors were used to stably transfer and express the cDNA encoding rabbit CYP4B1 in mouse C3H/10T1/2 cells. The replication defective retroviral vector was packaged in the ecotropic packaging cell line, GP+E-86, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffe0ea1a2fb5aa65c9e0b54aba08fd5
https://doi.org/10.1016/0006-2952(95)02029-2
https://doi.org/10.1016/0006-2952(95)02029-2
Autor:
Wellington V. Cardoso, A. Gebremichael, Alan R. Buckpitt, Richard M. Philpot, Charles G. Plopper, Chunmei Ji, Kent E. Pinkerton
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 269:L394-L402
Because a number of studies suggest that the developmental expression of cytochrome P-450s (CYP) in Clara cells is species specific, this study was designed to compare the developmental patterns of the isoform CYP2B and NADPH reductase protein expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40a16afb1d0c59ff4b5f25c57f64168
https://doi.org/10.1152/ajplung.1995.269.3.l394
https://doi.org/10.1152/ajplung.1995.269.3.l394
Autor:
Allan E. Rettie, Kenneth R. Korzekwa, Thomas A. Baillie, Richard M. Philpot, Pamela Sheffels, Frank J. Gonzalez
Publikováno v:
Biochemistry. 34:7889-7895
The cytochrome P450-dependent terminal desaturation of valproic acid (VPA) is of both toxicological and mechanistic interest because the product, 4-ene-VPA, is a more potent hepatotoxin than the parent compound and its generation represents a rather
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7719409a7c89718ec0ccf53b0b8ac683
https://doi.org/10.1021/bi00024a013
https://doi.org/10.1021/bi00024a013