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pro vyhledávání: '"Richard M. Phan"'
Publikováno v:
The Journal of Organic Chemistry. 81:5093-5100
Chain elongation prenyltransferases catalyze the addition of the hydrocarbon moiety of allylic isoprenoid diphosphates to the carbon-carbon double bond in isopentenyl diphosphate (IPP) in the primary building reactions in the isoprenoid biosynthetic
Autor:
C. Dale Poulter, Boxue Tian, Lawrence Blas Perez, Mark L. Pugh, Richard M. Phan, Matthew P. Jacobson, Gurusankar Ramamoorthy
Publikováno v:
The Journal of Organic Chemistry. 80:3902-3913
Farnesyl diphosphate synthase catalyzes the sequential chain elongation reactions between isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) to form geranyl diphosphate (GPP) and between IPP and GPP to give farnesyl diphosphate (FPP)
Autor:
Richard M. Phan, Poulter Cd
Publikováno v:
The Journal of Organic Chemistry. 66:6705-6710
Thiolo thiophosphate analogues of isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), farnesyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP) were synthesized. Inorganic thiopyrophosphate (SPP(i)) wa
Publikováno v:
The Journal of Organic Chemistry. 71:1739-1741
Short practical syntheses for five deuterium labeled derivatives of dimethylallyl diphosphate (DMAPP) useful for enzymological studies are reported. These include the preparation of the C1-labeled derivatives (R)-[1-2H]3-methylbut-2-enyl diphosphate
Autor:
C. Dale Poulter, Richard M. Phan
Publikováno v:
Organic Letters. 2:2287-2289
The tris(tetra-n-butylammonium) salt of thiopyrophosphate 5 was prepared from trimethyl phosphate in four steps. Treatment of geranyl bromide with 5 gave an 80% yield of geranyl S-thiolodiphosphate (6). Thiolodiphosphate 6 is substantially less react