Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Richard M. Keeling"'
Publikováno v:
Muscle & Nerve. 56:122-128
Objective: We studied mitochondrial impairment as a factor in the pathologic equivalent of sarcopenia, muscle fiber atrophy associated with increased age. Methods: Mitochondrial oxidative enzyme activities and coenzyme Q10 levels were measured in fro
Publikováno v:
Muscle & Nerve. 35:43-48
Although corticosteroids alleviate weakness in mdx mice, no long-term treatment has determined whether this benefit is maintained. We studied mdx mice forelimb grip strength and fatigue from 3 through 84 weeks and followed survival through 104 weeks.
Autor:
Kristin P. Bibee, Grace Hu, William D. Shannon, James Kain Ching, Samuel A. Wickline, Richard M. Keeling, Jon N. Marsh, Jacob W. Myerson, Ya-Jian Cheng, Conrad C. Weihl, Anne M. Connolly, Junjie Chen, Allison Jinquan Li, Gregory M. Lanza, Paul T. Golumbek
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(5)
Duchenne muscular dystrophy in boys progresses rapidly to severe impairment of muscle function and death in the second or third decade of life. Current supportive therapy with corticosteroids results in a modest increase in strength as a consequence
Publikováno v:
European Journal of Immunology. 29:3140-3147
T cell co-stimulation through the CD28 receptor on T cells is critical to the induction of experimental autoimmune encephalomyelitis (EAE). In this study, expression of the co-stimulatory ligands B7-1 (CD80) and B7-2 (CD86), as well as the receptors
Publikováno v:
Journal of Neuroimmunology. 96:144-147
Several laboratories including ours have shown that T cell co-stimulation mediated through B7-1 or B7-2 is critical to the initiation of EAE. The role of T cell co-stimulation in ongoing EAE is less clear. In the present study, 32 mice with establish
Autor:
Pamela S. Wyatt, Charles P. Rodi, Manuel San, Pamela T. Manning, Richard M. Keeling, Anne H. Cross, Salil Goorha, Thomas P. Misko
Publikováno v:
Journal of Neuroimmunology. 71:145-153
Messenger RNA encoding inducible NO synthase (iNOS) was measured by competitive reverse transcriptase polymerase chain reaction (cRT-PCR) and ribonuclease protection assays in spinal cords from mice at varying stages of experimental allergic encephal
Autor:
R. J. Evans, R.W. Karr, Thomas J. Girard, K. S. Giacoletto, John L. Trotter, Anne H. Cross, Robin F. Lin, Richard M. Keeling
Publikováno v:
Journal of Clinical Investigation. 95:2783-2789
T cell activation involves not only recognition of antigen presented by the MHC, but also nonspecific interactions termed "costimulation." The costimulatory molecules B7-1 and B7-2 are ligands on antigen-presenting cells for the CD28 and CTLA-4 recep
Publikováno v:
Development. 113:67-82
The highly regular pattern in which approximately 2000 small somatic cells and 16 large reproductive cells (or ‘gonidia’) are arranged in a typical asexual adult of Volvox carteri can be traced back to a stereotyped program of embryonic cleavage
Autor:
Steven L. Baldwin, Kirk D. Wallace, Richard M. Keeling, Jon N. Marsh, Anne M. Connolly, Gregory M. Lanza, S.A. Wickline, Michael S. Hughes
Publikováno v:
IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 54(11)
Duchenne muscular dystrophy is a severe wasting disease, involving replacement of necrotic muscle tissue by fibrous material and fatty infiltrates. One primary animal model of this human disease is the X chromosome-linked mdx strain of mice. The goal
Publikováno v:
Neuromuscular disorders : NMD. 17(5)
Corticosteroids improve muscle function in boys with Duchenne muscular dystrophy and mdx mice possibly via effects on T-cell and B-cells. We quantified T-cell/B-cell functional effects and refined prednisolone's therapeutic mechanism in mdx mice. RAG