Zobrazeno 1 - 10
of 737
pro vyhledávání: '"Richard M. Goldberg"'
Autor:
Patrick McGarrah MD, Joleen Hubbard MD, Paul J. Novotny MS, Megan E. Branda MS, Daniel S. Sargent PhD, Roscoe F. Morton MD, Charles S. Fuchs MD, Al B. Benson MD, Stephen K. Williamson MD, Brian P. Findlay MD, Steven R. Alberts MD, MPH, Richard M. Goldberg MD, Jeff A. Sloan PhD
Publikováno v:
Cancer Control, Vol 30 (2023)
Background Previous studies have established that higher baseline quality of life (QOL) scores are associated with improved survival in patients with metastatic colorectal cancer (mCRC). We examined the relationship between overall survival (OS) and
Externí odkaz:
https://doaj.org/article/3d9a8dee7cba4816a2b94d26e85684fe
Autor:
Fang-Shu Ou, Daniel H. Ahn, Jesse G. Dixon, Axel Grothey, Yiyue Lou, Pashtoon M. Kasi, Joleen M. Hubbard, Eric Van Cutsem, Leonard B. Saltz, Hans-Joachim Schmoll, Richard M. Goldberg, Alan P. Venook, Paulo Hoff, Jean-Yves Douillard, J. Randolph Hecht, Herbert Hurwitz, Cornelis J. A. Punt, Miriam Koopman, Carsten Bokemeyer, Charles S. Fuchs, Eduardo Diaz-Rubio, Niall C. Tebbutt, Chiara Cremolini, Fairooz F. Kabbinavar, Tanios Bekaii-Saab, Benoist Chibaudel, Takayuki Yoshino, John Zalcberg, Richard A. Adams, Aimery de Gramont, Qian Shi
Publikováno v:
Cancers, Vol 15, Iss 16, p 4117 (2023)
Metastatic colorectal cancer (mCRC) is a heterogeneous disease that can evoke discordant responses to therapy among different lesions in individual patients. The Response Evaluation Criteria in Solid Tumors (RECIST) criteria do not take into consider
Externí odkaz:
https://doaj.org/article/ce222f9467be42278701433a1ee37c17
Autor:
Midhun Malla, Fatemeh Fekrmandi, Nadia Malik, Hassan Hatoum, Sagila George, Richard M. Goldberg, Sarbajit Mukherjee
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Pancreatic cancer is the fourth leading cause of cancer mortality in the United States. Chemotherapy in resectable pancreatic cancer has improved survival by 10-20%. It only converted 10-30% of the borderline resectable and locally advanced pancreati
Externí odkaz:
https://doaj.org/article/0c64f91c8a46448a9a189fe81a0bd134
Autor:
Alberto Puccini, Andreas Seeber, Joanne Xiu, Richard M. Goldberg, Davide Soldato, Axel Grothey, Anthony F. Shields, Mohamed E. Salem, Francesca Battaglin, Martin D. Berger, Wafik S. El-Deiry, Ryuma Tokunaga, Madiha Naseem, Wu Zhang, Sukeshi Patel Arora, Moh’d M. Khushman, Michael J. Hall, Philip A. Philip, John L. Marshall, W. Michael Korn, Heinz-Josef Lenz
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-8 (2021)
Abstract Lymph nodes (LNs) and distant metastases can arise from independent subclones of the primary tumor. Herein, we characterized the molecular landscape and the differences between LNs, distant metastases and primary colorectal cancers (CRCs). S
Externí odkaz:
https://doaj.org/article/c05cb963898a4501a8b4034e06807f08
Autor:
Sigurdis Haraldsdottir, Thorunn Rafnar, Wendy L. Frankel, Sylvia Einarsdottir, Asgeir Sigurdsson, Heather Hampel, Petur Snaebjornsson, Gisli Masson, Daniel Weng, Reynir Arngrimsson, Birte Kehr, Ahmet Yilmaz, Stefan Haraldsson, Patrick Sulem, Tryggvi Stefansson, Peter G. Shields, Fridbjorn Sigurdsson, Tanios Bekaii-Saab, Pall H. Moller, Margret Steinarsdottir, Kristin Alexiusdottir, Megan Hitchins, Colin C. Pritchard, Albert de la Chapelle, Jon G. Jonasson, Richard M. Goldberg, Kari Stefansson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Lynch syndrome is characterized by predisposition to colorectal cancer and mutations in genes involved in mismatch repair. Here, the authors use whole genome sequencing and immunohistochemistry of mismatch repair proteins to show a high prevalence of
Externí odkaz:
https://doaj.org/article/892427e1e8434dbab0cf538d0c78f168
Autor:
Kai Zimmer, Alberto Puccini, Joanne Xiu, Yasmine Baca, Gilbert Spizzo, Heinz-Josef Lenz, Francesca Battaglin, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, Mohamed E. Salem, John L. Marshall, W. Michael Korn, Dominik Wolf, Florian Kocher, Andreas Seeber
Publikováno v:
Cancers, Vol 12, Iss 5, p 1319 (2020)
Werner syndrome gene (WRN) contributes to DNA repair. In cancer, WRN mutations (WRN-mut) lead to genomic instability. Thus, WRN is a promising target in cancers with microsatellite instability (MSI). We assessed this study to investigate the molecula
Externí odkaz:
https://doaj.org/article/91bc5f397a4445e3a025e7fca981d198
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 5 (2013)
Colorectal cancer is the third most common cancer in the Western population and has a 5-year overall survival of 5–10% when metastatic. Approximately 30% of the patients with metastatic colorectal cancer have limited disease apparently isolated to
Externí odkaz:
https://doaj.org/article/93ebd6151dde4398811cac80dda4e61e
Autor:
Fang-Shu Ou, Emil Lou, Joanne Xiu, Hiroyuki Arai, Francesca Battaglin, Heinz-Josef Lenz, Richard M Goldberg, Anthony F Shields, Yasmine Baca, Philip A Philip, John L Marshall, W Michael Korn, Andreas Seeber, Natsuko Kawanishi, Jingyuan Wang, Shivani Soni, Wu Zhang, Shannon M Mumenthaler, Joshua Millstein, Priya Jayachandran, Federico Innocenti, Annika Lenz, Sandra Algaze, Taline Khoukaz, Evanthia Roussos Torres, Jim P Abraham, Benjamin A Weinberg, Alan P Venook
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 1 (2024)
Background The C-C motif chemokine receptor 5 (CCR5)/C-C motif chemokine ligand 5 (CCL5) axis plays a major role in colorectal cancer (CRC). We aimed to characterize the molecular features associated with CCR5/CCL5 expression in CRC and to determine
Externí odkaz:
https://doaj.org/article/0070d43d733f41d1a13e1ef74847bb8d
Autor:
Claire Gallois, Qian Shi, Jeffrey P. Meyers, Timothy Iveson, Steven R. Alberts, Aimery de Gramont, Alberto F. Sobrero, Daniel G. Haller, Eiji Oki, Anthony Frank Shields, Richard M. Goldberg, Rachel Kerr, Sara Lonardi, Greg Yothers, Caroline Kelly, Ioannis Boukovinas, Roberto Labianca, Frank A. Sinicrope, Ioannis Souglakos, Takayuki Yoshino, Jeffrey A. Meyerhardt, Thierry André, Demetris Papamichael, Julien Taieb
Publikováno v:
Journal of Clinical Oncology. 41:803-815
PURPOSE Oxaliplatin-based adjuvant chemotherapy in patients with stage III colon cancer (CC) for 6 months remains a standard in high-risk stage III patients. Data are lacking as to whether early discontinuation of all treatment (ETD) or early discont
Autor:
Jan Franko, Jun Yin, Richard A. Adams, John Zalcberg, Jack Fiskum, Eric Van Cutsem, Richard M. Goldberg, Herbert Hurwitz, Carsten Bokemeyer, Fairooz Kabbinavar, Alexandra Curtis, Jeffery Meyers, Benoist Chibaudel, Takayuki Yoshino, Aimery de Gramont, Qian Shi
Publikováno v:
European Journal of Cancer. 174:142-152
Higher body mass index is associated with a higher incidence of colorectal cancer (CRC) but also with improved survival in metastatic CRC (mCRC). Whether weight change after mCRC diagnosis is associated with survival remains largely unknown.We analys