Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Richard M. Fine"'
Autor:
Chi Ching Mak, Xianchang Gong, Elena Dneprovskaia, Andrew McPherson, Ved P. Pathak, J. Hood, Binqi Zeng, Boris Klebansky, Richard M. Fine, W. Liao, Wolfgang Wrasidlo, Glenn Noronha, Joel Renick, Ningning Zhao, Y. Zhou, Kathy Barrett, Colleen Gritzen, Moorthy S. S. Palanki, Xinshan Kang, Ge Li, Ute Splittgerber, Richard M. Soll, Daniel L. Lohse, Jianguo Cao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5546-5550
We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c3a59d9d64cb5d6108ec85b738a7b4
https://doi.org/10.1016/j.bmcl.2006.08.035
https://doi.org/10.1016/j.bmcl.2006.08.035
Autor:
Glen Noronha, Jianguo Cao, Chun Chow, Elena Dneprovskaia, Linda Hwang, Dan Lohse, Chi Ching Mak, Andrew McPherson, Richard M. Fine, Xinshan Kang, Boris Klebansky, Moorthy S.S. Palanki, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d4f3146de588732bf746c8ec5d69ab
https://doi.org/10.2174/978160805201110703010121
https://doi.org/10.2174/978160805201110703010121
Autor:
Sarah J. Duellman, Jeremiah P. Malerich, Christopher Hutson, Peter B. Madrid, Richard M. Fine, Boris Keblansky, Julie Fong, Mary J. Tang, Bryan T. Glaser
Publikováno v:
Journal of biomolecular screening. 16(2)
DNA gyrase, a type II topoisomerase that introduces negative supercoils into DNA, is a validated antibacterial drug target. The holoenzyme is composed of 2 subunits, gyrase A (GyrA) and gyrase B (GyrB), which form a functional A(2)B(2) heterotetramer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f79fb8ac2654cd675d112a6e43d6b2
https://pubmed.ncbi.nlm.nih.gov/21245469
https://pubmed.ncbi.nlm.nih.gov/21245469
Autor:
Guy Servant, Haitian Liu, Catherine Tachdjian, Feng Zhang, Hong Xu, Boris Klebansky, Richard M. Fine, Mark Zoller, Xiaodong Li
Positive allosteric modulators of the human sweet taste receptor have been developed as a new way of reducing dietary sugar intake. Besides their potential health benefit, the sweet taste enhancers are also valuable tool molecules to study the genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff1393eed61ca40fee59198226f5c27
https://europepmc.org/articles/PMC2842058/
https://europepmc.org/articles/PMC2842058/
Autor:
Jürgen Bajorath, Richard M. Fine
Publikováno v:
ImmunoMethods. 1:137-146
We describe an approach to modeling the combining sites of antibodies that is based on energy minimization from many randomly generated starting conformations. This technique combines the Random Tweak method for loop backbone generation with a combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05e91d1e3ed9a21ad3ee193bcc2e44af
https://doi.org/10.1016/s1058-6687(05)80036-1
https://doi.org/10.1016/s1058-6687(05)80036-1
Autor:
Feng Zhang, Hong Xu, Xiaodong Li, Haitian Liu, Catherine Tachdjian, Alexey Pronin, Boris Klebansky, Richard M. Fine
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(52)
Umami is one of the 5 basic taste qualities. The umami taste of L-glutamate can be drastically enhanced by 5′ ribonucleotides and the synergy is a hallmark of this taste quality. The umami taste receptor is a heteromeric complex of 2 class C G-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90f3d91bfeaf6908297a96d842abcab
https://pubmed.ncbi.nlm.nih.gov/19104071
https://pubmed.ncbi.nlm.nih.gov/19104071
Autor:
Elena Dneprovskaia, Daniel L. Lohse, Richard Soll, Andrew McPherson, Chi Ching Mak, John Hood, Boris Klebansky, Richard M. Fine, Joel Renick, Jianguo Cao, Chun P. Chow, Moorthy S. S. Palanki, Glenn Noronha, Ved P. Pathak, Binqi Zeng, Xinshan Kang
Publikováno v:
Current topics in medicinal chemistry. 8(10)
Chronic myelogenous leukemia (CML) is a hematological stem cell disorder caused by increased and unregulated growth of myeloid cells in the bone marrow, and the accumulation of excessive white blood cells. Abelson tyrosine kinase (ABL) is a non-recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12165fa94b4010e1abb10fefa72becb6
https://pubmed.ncbi.nlm.nih.gov/18673174
https://pubmed.ncbi.nlm.nih.gov/18673174
Autor:
Ved P. Pathak, Chun P. Chow, Shiyin Yee, Michael D. Martin, Binqi Zeng, Hong Zhu, Shu Kachi, John Doukas, Naoyasu Umeda, Andrew McPherson, Dellamary Luis A, Hideo Akiyama, J. Hood, Boris Klebansky, Moorthy S.S. Palanki, Richard M. Fine, Katsutoshi Yokoi, Peter A. Campochiaro, Ahmed A Kousba, Joel Renick, Glenn Noronha, Dan Lohse, Xinshan Kang, Richard M. Soll, Colleen Gritzen, Chi Ching Mak, Steven Hu, Jianguo Cao
Publikováno v:
Journal of medicinal chemistry. 51(6)
Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to treat AMD has been validated clinically. A large body of evidence suggests that inhibitors ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60c2e3e531b4630c43bbf6701bffacd
https://pubmed.ncbi.nlm.nih.gov/18311895
https://pubmed.ncbi.nlm.nih.gov/18311895
Autor:
Shiyin Yee, John Doukas, Wolfgang Wrasidlo, Michael D. Martin, Hong Zhu, John Hood, Moorthy S. S. Palanki, Daniel L. Lohse, Glenn Noronha, Richard Soll, Xinshan Kang, Richard M. Fine, Elena Dneprovskaia
Publikováno v:
Journal of medicinal chemistry. 50(18)
In studies aimed toward identifying effective and safe inhibitors of kinase signaling cascades that underlie ischemia/reperfusion (I/R) injury, we synthesized a series of pteridines and pyridopyrazines. The design strategy was inspired by the examina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9556434a69a57d5e8f096abf079df2
https://pubmed.ncbi.nlm.nih.gov/17685602
https://pubmed.ncbi.nlm.nih.gov/17685602
Autor:
Moorthy S. S. Palanki, Elena Dneprovskaia, John Doukas, Richard M. Fine, John Hood, Xinshan Kang, Dan Lohse, Michael Martin, Glenn Noronha, Richard M. Soll, Wolfgang Wrasidlo, Shiyin Yee, Hong Zhu
Publikováno v:
Journal of Medicinal Chemistry; Sep2007, Vol. 50 Issue 18, p4279-4294, 16p