Výsledky vyhledávání - "Richard M. England"

Method to Investigate the Distribution of Water-Soluble Drug-Delivery Systems in Fresh Frozen Tissues Using Imaging Mass Cytometry

Autor: Richard M. England, Richard J. A. Goodwin, Stephanie Ling, Jonathan A. Rose, Nicole Strittmatter, Marianne Ashford, Ian Purvis, Alan M. Race, Daniel Sutton, Jennifer I. Moss, Edmond Wong, Ruth Macdonald, Simon T. Barry, Gareth Maglennon

Publikováno v: Analytical Chemistry. 93:3742-3749

Imaging mass cytometry (IMC) offers the opportunity to image metal- and heavy halogen-containing xenobiotics in a highly multiplexed experiment with other immunochemistry-based reagents to distinguish uptake into different tissue structures or cell t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77823ccf3774c54ef14fdc86b398b9da
https://doi.org/10.1021/acs.analchem.0c03908

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Designing Highly Stable Poly(sarcosine)-based Telodendrimer Micelles with High Drug Content Exemplified with Fulvestrant

Autor: Qing Yu, Richard M. England, Anders Gunnarsson, Robert Luxenhofer, Kevin Treacher, Marianne B. Ashford

Polymeric micelles have been extensively used as nanocarriers for the delivery of chemotherapeutic agents, aiming to improve their efficacy in cancer treatment. However, the poor loading capacity, premature drug release, non-uniformity, and reproduci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3e193624ec3fde94143afa692ad67d
https://doi.org/10.26434/chemrxiv-2021-p3jf5

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Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression

Autor: Anna Schantz, Sanyogitta Puri, Stephanie M. Bates, Edward J. Sayers, Richard M. England, Arwyn Tomos Jones, Maya Beano, Samantha Peel, Arpan S. Desai, Marianne Ashford

Publikováno v: Mol Ther

Lipid nanoparticles have great potential for delivering nucleic-acid-based therapeutics, but low efficiency limits their broad clinical translation. Differences in transfection capacity between in vitro models used for nanoparticle pre-clinical testi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb98452992fd2857b632619be0095af
https://doi.org/10.1016/j.ymthe.2019.07.018

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Evaluating liver uptake and distribution of different poly(2-methyl-2-oxazoline) modified lysine dendrimers following intravenous administration

Autor: Marianne Ashford, Bård Smedsrød, Jennifer I. Moss, Kjetil Elvevold, Richard M. England, Hill Kathryn Jane

Publikováno v: Biomaterials Science. 7:3418-3424

We report on the synthesis of four poly(2-methyl-2-oxazoline) modified lysine dendrimers with different residual groups or modifications on the dendrimer core, including: amino groups (positive charge), carboxyl groups (negative charge), and two drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d257af56e79f1682096b6bdff073cb
https://doi.org/10.1039/c9bm00385a

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Enhanced cytocompatibility and functional group content of poly(l-lysine) dendrimers by grafting with poly(oxazolines)

Autor: Marianne Ashford, Simon T. Barry, Kevin Treacher, Michael J. Waring, Cameron Alexander, Paul D. Kemmitt, Richard M. England, Jennifer I. Hare

Publikováno v: Polymer Chemistry. 7:4609-4617

When considering the design of an advanced drug delivery system, a common desirable attribute is to have a prolonged residence time in blood circulation so that accumulation and localised payload release may occur at the site of interest (e.g. a tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69d0b2bf275ac1470e44860260dc1894
https://doi.org/10.1039/c6py00478d

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Polyacetal-Based Combination Therapy for the Treatment of Prostate Cancer

Autor: María J. Vicent, Thipapun Plyduang, Julie Movellan, Ruedeekorn Wiwattanapatapee, Richard M. England, Ana Armiñán

Publikováno v: Macromolecular rapid communications. 39(19)

The high incidence of prostate carcinogenesis has prompted the search for novel effective treatment approaches. We have employed curcumin (Curc) and diethylstilbestrol (DES) to synthesize a series of polyacetal (PA)-based combination conjugates for p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141e5db25675b6f8c54dcb7950721111
https://pubmed.ncbi.nlm.nih.gov/30062740

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Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers

Autor: Joanne Wilson, Jennifer Barnes, Cameron Alexander, Michael J. Waring, Simon T. Barry, Paul D. Kemmitt, Jennifer I. Hare, Aaron Smith, Richard M. England, Marianne Ashford, Nicole Strittmatter

Irinotecan is used clinically for the treatment of colorectal cancer; however, its utility is limited by its narrow therapeutic index. We describe the use of a generation 5 l-lysine dendrimer that has been part-modified with a polyoxazoline as a drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c5fff49244e8dffb9457c4e689a206

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Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery

Autor: Richard M. England, Eric Lopez-Mocholi, Marta Cases-Villar, Ana Alastrue-Agudo, María J. Vicent, Raquel Requejo-Aguilar, Victoria Moreno-Manzano

Publikováno v: BIOMATERIALS
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. Animal models of acute SCI have provided evidence that transplantation of ependymal stem/progenitor cells of the spinal cord (epSPCs) induces functional recovery, while

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b8fb5ca1782e828034752e894b8ff3
https://pubmed.ncbi.nlm.nih.gov/27810639

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