Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Richard M. Eglen"'
Autor:
Terry Reisine, Richard M. Eglen
Publikováno v:
Pharmaceuticals, Vol 4, Iss 2, Pp 244-272 (2011)
GPCRs play a critical role in human physiology and are a prime target for drug discovery globally. Novel insights into the functions of GPCRs are providing unique approaches to modulate these proteins to generate unique drug candidates. Next generati
Externí odkaz:
https://doaj.org/article/fd35d00774344c989d8a6cc84bb349e8
Autor:
Joe Horecka, Neil W. Charter, Betty L. Bosano, Peter Fung, Phil Kobel, Kun Peng, Richard M. Eglen
Publikováno v:
BioTechniques, Vol 40, Iss 3, Pp 381-383 (2006)
Externí odkaz:
https://doaj.org/article/8e6d8b563d944fd18cbf8e2d8669e623
Autor:
Jurgen Wess, Celine Valant, Andrew B. Tobin, David Thal, Roy D. Schwarz, Neil M. Nathanson, Ernst Mutschler, Fred Mitchelson, Chris Langmead, Günter Lambrecht, Heinz J. Kilbinger, Rudolf Hammer, Christian C. Felder, Frederick Ehlert, Richard M. Eglen, Arthur Christopoulos, R.A. John Challiss, Noel J. Buckley, David A. Brown, Sophie Bradley, Nigel J. M. Birdsall
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Autor:
Frank Yocca, Carlos M. Villalon, Andrew Sleight, Trevor Sharp, Pramod R. Saxena, Bryan Roth, John A. Peters, Stephen J. Peroutka, John Neumaier, Ewan Mylecharane, Derek N. Middlemiss, Graeme R. Martin, Luc Maroteaux, Klaus Peter Latté, Patrick P. A. Humphrey, Daniel Hoyer, Rebecca Hills, Katharine Herrick-Davis, Julie Hensler, René Hen, Paul R. Hartig, Michel Hamon, Mark Hamblin, Manfred Göthert, Richard M. Eglen, Aline Dumuis, Marlene L. Cohen, Amy Butler, Theresa Branchek, Joel Bockaert, Gordon Baxter, Nicholas M. Barnes, Rodrigo Andrade
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversi
Autor:
Neil M. Nathanson, Jürgen Wess, Rudolf Hammer, R. A. John Challiss, Richard M. Eglen, Fred Mitchelson, David Brown, Sophie J. Bradley, Celine Valant, Heinz Kilbinger, Chris Langmead, Frederick J. Ehlert, Andrew B. Tobin, Noel J. Buckley, Ernst Mutschler, Günter Lambrecht, Arthur Christopoulos, David M. Thal, Roy D. Schwarz, Nigel J. M. Birdsall, Christian C. Felder
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Autor:
Frederick J. Ehlert, Nigel J. M. Birdsall, Ernst Mutschler, Heinz Kilbinger, Günter Lambrecht, Neil M. Nathanson, Roy D. Schwarz, Sophie J. Bradley, Richard M. Eglen, Christian C. Felder, David M. Thal, R. A. John Challiss, Rudolf Hammer, Andrew B. Tobin, Jürgen Wess, Arthur Christopoulos, Celine Valant, Noel J. Buckley, Fred Mitchelson, David Brown, Chris Langmead
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in
Autor:
Richard M. Eglen
Muscarinic Receptor Classification, M. Caulfield Muscarinic Acetylcholine Receptor Signaling Pathways in Smooth Muscle, R.A.J. Challiss and J.L. Blank Muscarinic Receptors and Gastrointestinal Smooth Muscle, F.J. Ehlert, E.A. Thomas, E.H. Gerstin, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b4f41a66dfa92b08c75efff478806c
https://doi.org/10.1201/9781003069027
https://doi.org/10.1201/9781003069027
Autor:
Pramod R. Saxena, Patrick P.A. Humphrey, Joël Bockaert, Rebecca Hills, Sleight Andrew, Rodrigo Andrade, Amy S. Butler, Bryan L. Roth, Graeme R. Martin, Frank D. Yocca, Stephen J. Peroutka, Manfred Göthert, Julie Hensler, Carlos M. Villalón, Katharine Herrick-Davis, Luc Maroteaux, Richard M. Eglen, Paul R. Hartig, Nicholas M. Barnes, M. Hamon, Theresa Branchek, Aline Dumuis, Klaus Peter Latté, Mark W. Hamblin, Trevor Sharp, Ewan J. Mylecharane, John F. Neumaier, René Hen, John A. Peters, Marlene L. Cohen, Derek N. Middlemiss, Gordon Baxter, Daniel Hoyer
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversi
Autor:
Celine Valant, Fred Mitchelson, Noel J. Buckley, David Brown, Neil M. Nathanson, Roy D. Schwarz, Nigel J. M. Birdsall, Christian C. Felder, Rudolf Hammer, Chris Langmead, Arthur Christopoulos, Günter Lambrecht, Frederick J. Ehlert, Richard M. Eglen, Jürgen Wess, Sophie J. Bradley, Ernst Mutschler, Heinz Kilbinger, Andrew B. Tobin, R. A. John Challiss
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
Muscarinic acetylcholine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [45]) are GPCRs of the Class A, rhodopsin-like family where the endogenous agonist is acetylcholine. In addition to the age
Autor:
Richard M. Eglen, Ye Fang
Publikováno v:
Slas Discovery
SLAS Discov
SLAS Discov
The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery b