Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Richard M. Angell"'
Autor:
Richard M. Angell, John Ludes-Meyers, Simon E. Ward, Michael Paradowski, Irina Chuckowree, Alexandre Bedernjak, James Lumley, Carol Villalonga Barber, Kenneth Powell, Edward Littler, Daniel Watterson, Geraldine Taylor, Elaine Thomas, Jose Gascon-Simorte, Mark E. Peeples, Michelle Thom, Jason S. McLellan, Dereck Tait, Neil Mathews, Paul R. Young, Ian M. Fraser, Morgan S.A. Gilman, James A. D. Good, G. Stuart Cockerill, Rachel Harland, Sara M. Johnson, Graham Lunn, Claire Scott, Gareth Williams
RV521 is an orally bioavailable inhibitor of respiratory syncytial virus (RSV) fusion that was identified after a lead optimization process based upon hits that originated from a physical property directed hit profiling exercise at Reviral. This exer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8371da7b3d3bd17095117d7ce4913054
https://orca.cardiff.ac.uk/id/eprint/143067/1/jm-2020-01882r.R2_Proof_hi.pdf
https://orca.cardiff.ac.uk/id/eprint/143067/1/jm-2020-01882r.R2_Proof_hi.pdf
Publikováno v:
SLAS Discovery. 18:219-225
The Aurora kinases are a group of serine/threonine protein kinases that regulate key steps during mitosis, and deregulation of these proteins (e.g., by gene amplification or overexpression) has been linked to a wide variety of tumor types. Thus, Auro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d8120265255ee2efaf35736233290a
https://doi.org/10.1177/1087057112459888
https://doi.org/10.1177/1087057112459888
Publikováno v:
Antiviral chemistrychemotherapy. 22(4)
In this review, we consider recent advances in the discovery and development of antiviral agents for respiratory syncytial virus (RSV) infections. A background to the various manifestations of human RSV infection and current treatments is provided. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14118d7ab8b40a6e0961da8ed6c74fb1
https://pubmed.ncbi.nlm.nih.gov/22182737
https://pubmed.ncbi.nlm.nih.gov/22182737
Autor:
Rupert E. Shaw, Andy J. Harker, Panayiotis Alexandro Procopiou, Michael A. Snowden, Colin M. Burgess, Helen E. Weston, Ashley Paul Hancock, Sarah Walton, Rob J. Stubbs, Rosanne M. Farrell, Richard M. Angell, Chris Ioannou, Onkar M. P. Singh, Wendy R. Irving, Yemisi E. Solanke, Keith Biggadike
Publikováno v:
Journal of medicinal chemistry. 43(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efd138007f0925d3f8cfe9a195fd5b6
https://pubmed.ncbi.nlm.nih.gov/10633034
https://pubmed.ncbi.nlm.nih.gov/10633034
Autor:
D. Christopher Braddock, Anthony G. M. Barrett, Steven Swallow, Richard M. Angell, Benjamin D. Vickery
Publikováno v:
Chemical Communications. :919
Condensation of aromatic aldehydes and (E)-but-2-enyl- trichlorosilane in the presence of (S)-(+)-4-(2-methylpropyl)-2-(2-pyridinyl)-2-oxazoline gives the corresponding homoallylic alcohols in excellent anti-diastereoselectivity (>99%) and good enant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f05672f2d879269756bb810b7edc4b08
https://doi.org/10.1039/a701244f
https://doi.org/10.1039/a701244f