Výsledky vyhledávání - "Richard M. Kellogg"

Akademický článek

Resolution of a Metastable Racemic Compound of Anhydrous Phencyphos by Hydrate Formation

Autor: Michel Leeman, Richard M. Kellogg

Publikováno v: Crystals, Vol 11, Iss 10, p 1225 (2021)

The resolution of 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide (phencyphos) was achieved by dissolution of anhydrous racemic phencyphos, a racemic compound, accompanied by simultaneous secondary nucleation of the dissolved racemate

Externí odkaz: https://doaj.org/article/eb5a6abf5ac5470a8f703f5ec79dd545

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Chiral Amplification through the Interplay of Racemizing Conditions and Asymmetric Crystal Growth

Autor: Sjoerd W. van Dongen, Imane Ahlal, Michel Leeman, Bernard Kaptein, Richard M. Kellogg, Iaroslav Baglai, Willem L. Noorduin

Publikováno v: Journal of the American Chemical Society.

Amplification of enantiomeric excesses (ee) is routinely observed during chiral crystallization of conglomerate crystals for which the enantiomers undergo racemization in solution. Although routes comprising a combination of crystal growth and dissol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd2b04c2b1afedcd8e244d96d786d5a
https://pubmed.ncbi.nlm.nih.gov/36534614

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Performance Analysis and Model-Free Design of Deracemization via Temperature Cycles

Autor: Marco Mazzotti, Willem L. Noorduin, Richard M. Kellogg, Michel Leeman, Iaroslav Baglai, Francesca Breveglieri

Publikováno v: Organic Process Research & Development, 24 (8)
Organic Process Research & Development

Solid-state deracemization via temperature cycles is a technique that has been shown to be effective to isolate the pure enantiomer of a conglomerate-forming compound. This process has a large number of operating parameters that can be adjusted accor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc1a0ec36cfdfea090dfa58b75f44c8
https://doi.org/10.1021/acs.oprd.0c00266

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Counteracting Enantiospecific Behavior of Tailor-Made Additives During Chiral Symmetry Breaking: Growth Inhibition versus Solid-Solution Formation

Autor: Richard M. Kellogg, Sjoerd W. van Dongen, Iaroslav Baglai, Willem L. Noorduin, Bernard Kaptein, Michel Leeman

Publikováno v: Israel journal of chemistry, 61(9-10), 645-649. Wiley-Blackwell

All biological systems are composed of molecules of a single chirality. Although many different scenarios can lead to chiral symmetry breaking, the transmission of the absolute configuration of one compound to another one remains challenging. We here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a63417acab4043f4a042207195484eb
https://dare.uva.nl/personal/pure/en/publications/counteracting-enantiospecific-behavior-of-tailormade-additives-during-chiral-symmetry-breaking-growth-inhibition-versus-solidsolution-formation(645e18d7-e7e0-4c12-a2cb-62a995654987).html

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A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Autor: Willem L. Noorduin, Michel Leeman, Richard M. Kellogg, Iaroslav Baglai

Publikováno v: Organic & Biomolecular Chemistry. 17:35-38

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35947b53797f157e046dec92952003f
https://doi.org/10.1039/c8ob02660b

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Combining Incompatible Processes for Deracemization of a Praziquantel Derivative under Flow Conditions

Autor: Michel Leeman, Iaroslav Baglai, Joop H. ter Horst, Willem L. Noorduin, Giulio Valenti, Bernard Kaptein, Richard M. Kellogg, Paul Tinnemans

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie, International Edition, 60(10), 5279-5282. John Wiley and Sons Ltd
Angewandte Chemie. International Edition, 60, 5279-5282
Angewandte Chemie. International Edition, 60, 10, pp. 5279-5282
Angewandte Chemie, 133(10), 5339-5342. John Wiley and Sons Ltd

An efficient deracemization method for conversion of the racemate to the desirable (R)-enantiomer of Praziquantel has been developed by coupling incompatible racemization and crystallization processes. By a library approach, a derivative that crystal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620205bed4f121713b080dafc5605237

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Enantiospecific Solid Solution Formation Triggers the Propagation of Homochirality

Autor: Iaroslav Baglai, Willem L. Noorduin, Klaus Wurst, Richard M. Kellogg, Michel Leeman

Publikováno v: Angewandte Chemie (International ed. in English). 59(47)

Propagation of homochirality plays a crucial role in the discussion on the origin of life. We investigated the role of structurally related enantiopure additives in chiral symmetry breaking during reactive crystallizations. We demonstrate that symmet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a5ebdb3357471610717a7096bdef94
https://pubmed.ncbi.nlm.nih.gov/32780534

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Akademický článek

A Tribute to Prof. Binne Zwanenburg

Autor: Richard M. Kellogg

Publikováno v: ARKIVOC, Vol 2004, Iss 2, Pp 1-3 (2003)

Externí odkaz: https://doaj.org/article/b47a2f7d0cb949c4893450e11bcc7438

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