Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richard M Monaghan"'
Autor:
Richard M Monaghan, Alan J Whitmarsh
Publikováno v:
eLife, Vol 4 (2015)
Drugs that change the shape of AKT, a protein kinase that promotes tumor growth, may be more effective than drugs that only target its enzymatic activity.
Externí odkaz:
https://doaj.org/article/8cd68bde0ac346b4aef6cea6e17b261f
Publikováno v:
Monaghan, R M, Page, D J, Ostergaard, P & Keavney, B D 2021, ' The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases ', Cardiovascular research, vol. 117, no. 8, pp. 1877-1890 . https://doi.org/10.1093/cvr/cvaa291, https://doi.org/10.1093/cvr/cvaa291
Cardiovascular Research
Monaghan, R M, Page, D J, Ostergaard, P & Keavney, B D 2021, ' The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases ', Cardiovascular research, vol. 117, no. 8, pp. 1877-1890 . https://doi.org/10.1093/cvr/cvaa291
Cardiovascular Research
Monaghan, R M, Page, D J, Ostergaard, P & Keavney, B D 2021, ' The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases ', Cardiovascular research, vol. 117, no. 8, pp. 1877-1890 . https://doi.org/10.1093/cvr/cvaa291
Vascular endothelial growth factor receptors (VEGFRs) are part of the evolutionarily conserved VEGF signalling pathways that regulate the development and maintenance of the body’s cardiovascular and lymphovascular systems. VEGFR3, encoded by the FL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28988ac9287174028910e2622c11da38
https://doi.org/10.1093/cvr/cvaa291
https://doi.org/10.1093/cvr/cvaa291
Autor:
Doreen A. Cantrell, Mitchell Lindsay, Lindsey A. Edwards, R Budd, L K J Stadler, Camille Parsons, Christopher Rush, E Tobias, S Abraham, Jeremy Hughes, Muhammad Javaid, S R Walmsley, Simon G. Williams, Graham Rena, Aadil Shaukat, R Moon, Gennadiy Tenin, Mohapradeep Mohan, J Marshall, Y Liu, Bernard Keavney, P Hua, E R Watt, Donna J. Page, Ify Mordi, Mun-Kit Choy, Nicholas C. Harvey, Sachith Mettananda, Richard Good, Peter McCartney, J McCafferty, Robert Fraser, S V Gandhi, Damien Collison, A van der Klaauw, Fatma Gossiel, James O.J. Davies, A Perikari, P Coelho, Shilpa Chokshi, Stuart Watkins, Ddd Study, M K B Whyte, M Bewley, David Corcoran, Aris T. Papageorghiou, Graeme C.M. Black, Antonio Riva, H Edwards, C. Cooper, J Keogh, Jens L. Hukelmann, Calum Forteath, Richard M. Monaghan, L Diver, Kate Maslin, G Gazdagh, Keith Robertson, Roger Williams, A Wong, Rhian M. Touyz, Elizabeth M Curtis, E Ryan, Doug Higgs, Vishal C. Patel, W Rumsey, Keith G. Oldroyd, T M Cacciottolo, T M Plant, Stefania D'Angelo, Colin N. A. Palmer, Thomas J. Ford, Matthieu J. Miossec, E Fotiou, A Mirchandani, M Santibanez-Koref, Chim C. Lang, Inez Schoenmakers, P Sadiku, Mohsin Badat, Stephen Kennedy, Sarah Crozier, David H. Dockrell, Colin Berry, Mark J. W. McPhail, Novalia Sidik, Nick Bishop, F Ahmed, Ron Schwessinger, Y Sanchez, I S Farooqi, Stuart Hood, Robert McDade, S Walmsley, Alex McConnachie, Bethany Stanley, Hazel Inskip, Alex S. F. Doney, Margaret McEntegart, Ross McGeoch, Paul Rocchiccioli, Andrew J. M. Howden, Hany Eteiba, Sarah Azarian, Ann Prentice, E Henning, R. Eastell, Keith M. Godfrey, R McGowan, Moira K. B. Whyte, Elizabeth Gray
Publikováno v:
DDD Study & CHANGE Study Collaborators, CheartED Study Collaborators 2019, ' Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland ', QJM : monthly journal of the Association of Physicians, vol. 112, no. 9, pp. 724-729 . https://doi.org/10.1093/qjmed/hcz175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74b98d2738544050a43a39fa9ea067c
https://www.research.manchester.ac.uk/portal/en/publications/scientific-business-abstracts-of-the-113th-annual-meeting-of-the-association-of-physicians-of-great-britain-and-ireland(ecd77393-a581-4779-8b0b-d90251ca1104).html
https://www.research.manchester.ac.uk/portal/en/publications/scientific-business-abstracts-of-the-113th-annual-meeting-of-the-association-of-physicians-of-great-britain-and-ireland(ecd77393-a581-4779-8b0b-d90251ca1104).html
Autor:
Gennadiy Tenin, Simon G. Williams, David W. Ray, Shona Borland, Richard M. Monaghan, Sabu Abraham, Matthew Baxter, Bernard Keavney
Publikováno v:
Basic Science.
Congenital heart disease describes a group of defects resulting from aberrant heart development. Tetralogy of Fallot is the most common cyanotic congenital heart defect. The causes of congenital heart disease are poorly understood. Histone modifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1e90e3b474b5c0db28afe5aafe63fac
https://doi.org/10.1136/heartjnl-2019-bcs.173
https://doi.org/10.1136/heartjnl-2019-bcs.173
Autor:
Martin Baron, John O'Sullivan, Elisavet Fotiou, Kathryn E. Hentges, Jeroen Breckpot, Mathieu Bourgey, Barbara J.M. Mulder, Alex V. Postma, William G. Newman, Connie R. Bezzina, Frances A. Bu'Lock, Marc Gewillig, Koenraad Devriendt, Graham Stuart, Heather J. Cordell, Bernard Keavney, David Brook, Robert Eveleigh, Simon G. Williams, Matthieu J. Miossec, James R. Bentham, Mauro Santibanez-Koref, Louise Sutcliffe, Mark Lathrop, Ana Töpf, Donna J. Page, Sally L. Dunwoodie, Richard M. Monaghan, Sanjeev S. Bhaskar, Kerry Setchfield, Guillaume Bourque, David S. Winlaw, Shoumo Bhattacharya, Graeme C.M. Black
Publikováno v:
Young Investigators Award.
Introduction There is strong evidence from familial recurrence studies for a genetic predisposition to sporadic, non-syndromic Tetralogy of Fallot (TOF). TOF is the most common, cyanotic congenital heart disease (CHD) phenotype yet the cause for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd97b941c4bba120bf4aed8b79315e29
https://doi.org/10.1136/heartjnl-2019-bcs.226
https://doi.org/10.1136/heartjnl-2019-bcs.226
Autor:
Kathryn E. Hentges, Robert Eveleigh, Mathieu Bourgey, Barbara J.M. Mulder, William G. Newman, Shoumo Bhattacharya, Sally L. Dunwoodie, Frances A. Bu'Lock, Ana Töpf, Richard M. Monaghan, Elisavet Fotiou, Graham Stuart, Simon G. Williams, Marc Gewillig, Connie R. Bezzina, Alex V. Postma, Guillaume Bourque, Kerry Setchfield, G. Mark Lathrop, Koenraad Devriendt, D Winlaw, J. David Brook, Heather J. Cordell, Graeme C.M. Black, James R. Bentham, Bernard Keavney, Mauro Santibanez-Koref, Matthieu J. Miossec, Louise Sutcliffe, Donna J. Page, Sanjeev S. Bhaskar, Martin Baron, John O'Sullivan, Jeroen Breckpot
Publikováno v:
Page, D J, Miossec, M J, Williams, S G, Monaghan, R M, Fotiou, E, Cordell, H J, Sutcliffe, L, Topf, A, Bourgey, M, Bourque, G, Eveleigh, R, Dunwoodie, S L, Winlaw, D S, Bhattacharya, S, Breckpot, J, Devriendt, K, Gewillig, M, Brook, J D, Setchfield, K J, Bu'Lock, F A, O'Sullivan, J, Stuart, G, Bezzina, C R, Mulder, B J M, Postma, A V, Bentham, J R, Baron, M, Bhaskar, S S, Black, G C, Newman, W G, Hentges, K E, Lathrop, G M, Santibanez-Koref, M & Keavney, B D 2019, ' Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot ', Circulation research, vol. 124, no. 4, pp. 553-563 . https://doi.org/10.1161/CIRCRESAHA.118.313250, https://doi.org/10.1161/CIRCRESAHA.118.313250
Circulation research, 124(4), 553-563. Lippincott Williams and Wilkins
Circulation research, 124(4), 553-563. Lippincott Williams and Wilkins
Rationale: Familial recurrence studies provide strong evidence for a genetic component to the predisposition to sporadic, nonsyndromic Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease phenotype. Rare genetic variants have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ef130c9628a90cd791742dc7a84be5
https://lirias.kuleuven.be/handle/123456789/631749
https://lirias.kuleuven.be/handle/123456789/631749
Autor:
Donna J. Page, Matthieu J. Miossec, Simon G. Williams, Elisavet Fotiou, Richard M. Monaghan, Heather J. Cordell, Louise Sutcliffe, Ana Topf, Mathieu Bourgey, Guillaume Bourque, Robert Eveleigh, Sally L. Dunwoodie, David S. Winlaw, Shoumo Bhattacharya, Jeroen Breckpot, Koenraad Devriendt, Marc Gewillig, David Brook, Kerry Setchfield, Frances A. Bu’Lock, John O’Sullivan, Graham Stuart, Connie Bezzina, Barbara J.M. Mulder, Alex V. Postma, James R. Bentham, Martin Baron, Sanjeev S. Bhaskar, Graeme C. Black, William G. Newman, Kathryn E. Hentges, Mark Lathrop, Mauro Santibanez-Koref, Bernard D. Keavney
AimsFamilial recurrence studies provide strong evidence for a genetic component to the predisposition to sporadic, non-syndromic Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease (CHD) phenotype. Rare genetic variants have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68be040d4834c06a04efd344c72ccb08
Autor:
Richard M. Monaghan, Alan J. Whitmarsh
Publikováno v:
Trends in Biochemical Sciences. 40:728-735
Mitochondria function as cellular energy generators, producing the fuel required to drive biological processes. The response of cells to mitochondrial activity or dysfunction regulates their survival, growth, proliferation, and differentiation. Sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6d68cf4deae61384d224d50d18cc4a
https://doi.org/10.1016/j.tibs.2015.10.003
https://doi.org/10.1016/j.tibs.2015.10.003
Autor:
Richard M. Monaghan, Alan J. Whitmarsh, Tereza Andreou, Gino B. Poulin, Robert G. Barnes, Kate Fisher, Nicholas Rooney
Publikováno v:
Nature cell biology
Monaghan, R M, Barnes, R G, Fisher, K, Andreou, T, Rooney, N, Poulin, G B & Whitmarsh, A J 2015, ' A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity ', Nature Cell Biology, vol. 17, no. 6, pp. 782-792 . https://doi.org/10.1038/ncb3170
Monaghan, R M, Barnes, R G, Fisher, K, Andreou, T, Rooney, N, Poulin, G B & Whitmarsh, A J 2015, ' A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity ', Nature Cell Biology, vol. 17, no. 6, pp. 782-792 . https://doi.org/10.1038/ncb3170
The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing. Mitochondria communicate with nuclei through retrograde signalling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1d03bc836a82a943f4d205827c27fb
https://pubmed.ncbi.nlm.nih.gov/25961505
https://pubmed.ncbi.nlm.nih.gov/25961505
Publikováno v:
Oncotarget
Mitochondria are organelles that host many metabolic processes, including the generation of energy in the form of adenosine triphosphate (ATP) through oxidative phosphorylation. They contain their own genome, however, the vast majority of mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935e53663da743a77e66fbda4d984c81
http://europepmc.org/articles/PMC4599232
http://europepmc.org/articles/PMC4599232