Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Richard M Higashi"'
Publikováno v:
eLife, Vol 10 (2021)
Cellular metabolism has key roles in T cells differentiation and function. CD4+ T helper-1 (Th1), Th2, and Th17 subsets are highly glycolytic while regulatory T cells (Tregs) use glucose during expansion but rely on fatty acid oxidation for function.
Externí odkaz:
https://doaj.org/article/851c6bd2a26549a4b642403b49029a4d
Autor:
Teresa WM Fan, Richard M Higashi, Huan Song, Saeed Daneshmandi, Angela L Mahan, Matthew S Purdom, Therese J Bocklage, Thomas A Pittman, Daheng He, Chi Wang, Andrew N Lane
Publikováno v:
eLife, Vol 10 (2021)
Although Pembrolizumab-based immunotherapy has significantly improved lung cancer patient survival, many patients show variable efficacy and resistance development. A better understanding of the drug’s action is needed to improve patient outcomes.
Externí odkaz:
https://doaj.org/article/6541a0fc470f4f33989f246beecdeb72
Autor:
Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy
Externí odkaz:
https://doaj.org/article/38460ce622de479f9a32204e95da4901
Publikováno v:
Metabolites, Vol 14, Iss 7, p 383 (2024)
Stable isotope-resolved metabolomics comprises a critical set of technologies that can be applied to a wide variety of systems, from isolated cells to whole organisms, to define metabolic pathway usage and responses to perturbations such as drugs or
Externí odkaz:
https://doaj.org/article/8b3c1301b8e9419f8c21761c958382d2
Autor:
Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N. Lane
Publikováno v:
Metabolites, Vol 13, Iss 7, p 774 (2023)
Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus
Externí odkaz:
https://doaj.org/article/d138aeef22d54272a4f32cf81e8a1281
Publikováno v:
Genes and Diseases, Vol 7, Iss 2, Pp 185-198 (2020)
The genetic alterations associated with cell transformation are in large measure expressed in the metabolic phenotype as cancer cells proliferate and change their local environment, and prepare for metastasis. Qualitatively, the fundamental biochemis
Externí odkaz:
https://doaj.org/article/b1e19b835a9e4ed394d02f9b006c0494
Autor:
Erika M. Palmieri, Marieli Gonzalez-Cotto, Walter A. Baseler, Luke C. Davies, Bart Ghesquière, Nunziata Maio, Christopher M. Rice, Tracey A. Rouault, Teresa Cassel, Richard M. Higashi, Andrew N. Lane, Teresa W.-M. Fan, David A. Wink, Daniel W. McVicar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Production of inflammatory mediators by M1-polarized macrophages is thought to rely on suppression of mitochondrial metabolism in favor of glycolysis. Refining this concept, here the authors define metabolic targets of nitric oxide as responsible for
Externí odkaz:
https://doaj.org/article/1aabd0cb2c6e480fa1e6ac1eb3b1dd56
Autor:
Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W.-M. Fan, Pankaj Seth
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108831- (2021)
Summary: Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide ade
Externí odkaz:
https://doaj.org/article/acce3d944b2e4a188f1edec534596d20
Autor:
Teresa W.-M. Fan, Saeed Daneshmandi, Teresa A. Cassel, Mohammad B. Uddin, James Sledziona, Patrick T. Thompson, Penghui Lin, Richard M. Higashi, Andrew N. Lane
Publikováno v:
The Journal of Immunology. 209:1674-1690
Immunomodulatory (IM) metabolic reprogramming in macrophages (Mϕs) is fundamental to immune function. However, limited information is available for human Mϕs, particularly in response plasticity, which is critical to understanding the variable effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015f94d81e93bf8fa3f459be7a2c1d7a
https://doi.org/10.4049/jimmunol.2200178
https://doi.org/10.4049/jimmunol.2200178
Autor:
Lane, Teresa W.-M. Fan, Jason Winnike, Ahmad Al-Attar, Alexander C. Belshoff, Pawel K. Lorkiewicz, Jin Lian Tan, Min Wu, Richard M. Higashi, Andrew N.
Publikováno v:
Metabolites; Volume 13; Issue 7; Pages: 774
Past chemopreventive human trials on dietary selenium supplements produced controversial outcomes. They largely employed selenomethionine (SeM)-based diets. SeM was less toxic than selenite or methylseleninic acid (MSeA) to lung cancer cells. We thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::52479623a25a714a153196810d2cdace