Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Richard M Chemelli"'
Autor:
Kristi A Kohlmeier, Christopher J Tyler, Mike eKalogiannis, Masaru eIshibashi, Morten P Kristensen, Iryna eGumenchuk, Richard M Chemelli, Yaz eKisanuki, Masashi eYanagisawa, Christopher S Leonard
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated b
Externí odkaz:
https://doaj.org/article/0aff8bd46db04e32bfd097713bf8e994
Autor:
Mike Kalogiannis, Emily Hsu, Jon T Willie, Richard M Chemelli, Yaz Y Kisanuki, Masashi Yanagisawa, Christopher S Leonard
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18697 (2011)
To investigate how cholinergic systems regulate aspects of the sleep disorder narcolepsy, we video-monitored mice lacking both orexin (hypocretin) receptors (double knockout; DKO mice) while pharmacologically altering cholinergic transmission. Sponta
Externí odkaz:
https://doaj.org/article/d71b6efbd3824739b64c34d8ee10a411
Autor:
Yaz Y. Kisanuki, P. E. Potter, Christopher S. Leonard, Mike Kalogiannis, John G. Edwards, Stephen L. Grupke, Masashi Yanagisawa, Richard M. Chemelli
Publikováno v:
European Journal of Neuroscience. 32:130-142
Pharmacological studies of narcoleptic canines indicate that exaggerated pontine cholinergic transmission promotes cataplexy. As disruption of orexin (hypocretin) signaling is a primary defect in narcolepsy with cataplexy, we investigated whether mar
Autor:
Yaz Y. Kisanuki, Joel K. Elmquist, Christopher S. Leonard, Shigeru Tokita, Charlotte E. Lee, Masashi Yanagisawa, Robert E. Hammer, James A. Richardson, Jacob Marcus, Christopher M. Sinton, Richard M. Chemelli, S. Clay Williams, Kristi A. Kohlmeier, Jon T. Willie
Publikováno v:
University of Copenhagen
Narcolepsy-cataplexy, a neurological disorder associated with the absence of hypothalamic orexin (hypocretin) neuropeptides, consists of two underlying problems: inability to maintain wakefulness and intrusion of rapid eye movement (REM) sleep into w
Autor:
Ivy V. Estabrooke, Marie T. McCarthy, Masashi Yanagisawa, Tom Chou, Emily M. Ko, Clifford B. Saper, Thomas E. Scammell, Richard M. Chemelli
Publikováno v:
The Journal of Neuroscience. 21:1656-1662
The neuropeptide orexin (also known as hypocretin) is hypothesized to play a critical role in the regulation of sleep-wake behavior. Lack of orexin produces narcolepsy, which is characterized by poor maintenance of wakefulness and intrusions of rapid
Autor:
Masashi Yanagisawa, Masamitsu Nakazato, Charlotte E. Lee, S. Clay Williams, Thomas Fitch, Joel K. Elmquist, Richard M. Chemelli, Thomas E. Scammell, Yaz Y. Kisanuki, James A. Richardson, Jon T. Willie, Clifford B. Saper, Christopher M. Sinton, Robert E. Hammer, Yumei Xiong
Publikováno v:
Cell. 98:437-451
Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to numerous regions throughout the central nervous system, including the major nuclei implicated in sleep regulation. Here, we
Autor:
Nabil Elshourbagy, Richard M. Chemelli, Roland S. Annan, Wu Schyong Liu, Jonathan R.S. Arch, S. Clay Williams, Makoto Ishii, Masashi Yanagisawa, Shelagh Wilson, Robin E. Buckingham, Akira Amemiya, Derk J. Bergsma, Jonathan A. Terrett, Ichiyo Matsuzaki, Gerald P. Kozlowski, Takeshi Sakurai, Steven A. Carr, Andrea C. Haynes, Hirokazu Tanaka, Dean E. McNulty, James A. Richardson
Publikováno v:
Scopus-Elsevier
The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related
Autor:
Yaz Y. Kisanuki, Mike Kalogiannis, Christopher S. Leonard, Jon T. Willie, Masashi Yanagisawa, Richard M. Chemelli, Emily Hsu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 4, p e18697 (2011)
PLoS ONE, Vol 6, Iss 4, p e18697 (2011)
To investigate how cholinergic systems regulate aspects of the sleep disorder narcolepsy, we video-monitored mice lacking both orexin (hypocretin) receptors (double knockout; DKO mice) while pharmacologically altering cholinergic transmission. Sponta
Autor:
Christopher M. Sinton, Thomas E. Scammell, Masashi Yanagisawa, William Renthal, Jon T. Willie, Matthew S. Miller, Richard M. Chemelli
Publikováno v:
Neuroscience. 130(4)
Narcolepsy-cataplexy, a disorder of excessive sleepiness and abnormalities of rapid eye movement (REM) sleep, results from deficiency of the hypothalamic orexin (hypocretin) neuropeptides. Modafinil, an atypical wakefulness-promoting agent with an un
Autor:
Fumihiro Sugiyama, Tadahiro Nambu, Christopher M. Sinton, Junko Hara, Carsten T. Beuckmann, Jon T. Willie, Katsutoshi Goto, Ken-ichi Yagami, Takeshi Sakurai, Masashi Yanagisawa, Richard M. Chemelli
Publikováno v:
Neuron. 30(2)
Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss of orexin-containing neurons occurs in human patients with narcolepsy. We generated transgenic mice in which orexin-conta