Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Richard M, van Rijn"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Modern methods for quantifying signaling bias at G protein–coupled receptors (GPCRs) rely on using a single β-arrestin isoform. However, it is increasingly appreciated that the two β-arrestin isoforms have unique roles, requiring the
Externí odkaz:
https://doaj.org/article/226cef4e1ff64cb6bf6f37cbbe6fe9e4
Autor:
Logan Ganzen, Mee Jung Ko, Mengrui Zhang, Rui Xie, Yongkai Chen, Liyun Zhang, Rebecca James, Jeff Mumm, Richard M. van Rijn, Wenxuan Zhong, Chi Pui Pang, Mingzhi Zhang, Motokazu Tsujikawa, Yuk Fai Leung
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Retinitis Pigmentosa (RP) is a mostly incurable inherited retinal degeneration affecting approximately 1 in 4000 individuals globally. The goal of this work was to identify drugs that can help patients suffering from the disease. To accompli
Externí odkaz:
https://doaj.org/article/b5731b7fd28248bebf064ea1a3089211
Autor:
Arryn T. Blaine, Yiming Miao, Jinling Yuan, Sophia Palant, Rebecca J. Liu, Zhong-Yin Zhang, Richard. M. van Rijn
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The δ-opioid receptor (δOR) has been considered as a therapeutic target in multiple neurological and neuropsychiatric disorders particularly as δOR agonists are deemed safer alternatives relative to the more abuse-liable µ-opioid receptor drugs.
Externí odkaz:
https://doaj.org/article/ca344bb1a084418dbaf758bf8b8f1159
Publikováno v:
Pharmacological Research, Vol 177, Iss , Pp 106091- (2022)
Kappa opioid receptor (κOR) agonists lack the abuse liability and respiratory depression effects of clinically used mu opioid receptor (μOR) analgesics and are hypothesized to be safer alternatives. However, κOR agonists have limiting adverse effe
Externí odkaz:
https://doaj.org/article/f4cae45bd8d543e78f83cd7f482312fd
Autor:
Anna M. Gutridge, Soumen Chakraborty, Balazs R. Varga, Elizabeth S. Rhoda, Alexander R. French, Arryn T. Blaine, Quinten H. Royer, Haoyue Cui, Jinling Yuan, Robert J. Cassell, Márk Szabó, Susruta Majumdar, Richard M. van Rijn
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background and Purpose:Mitragyna speciosa extract and kratom alkaloids decrease alcohol consumption in mice at least in part through actions at the δ-opioid receptor (δOR). However, the most potent opioidergic kratom alkaloid, 7-hydroxymitragynine,
Externí odkaz:
https://doaj.org/article/f8fafb8540364aecb9a53a3c306b49b7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9888 (2022)
The subventricular zone (SVZ) in lateral ventricles is the largest neurogenic region in adult brain containing high amounts of copper (Cu). This study aims to define the role of Cu in adult neurogenesis by chelating labile Cu ions using a well-establ
Externí odkaz:
https://doaj.org/article/140cdcfa158a42e39332fe5a7ff8bf95
Autor:
Yazan J. Meqbil, Richard M. van Rijn
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 873 (2022)
The delta opioid receptor is a Gi-protein-coupled receptor (GPCR) with a broad expression pattern both in the central nervous system and the body. The receptor has been investigated as a potential target for a multitude of significant diseases includ
Externí odkaz:
https://doaj.org/article/25a70c9ce2f242af91ec9b40af684843
Autor:
Richard M. Van Rijn, Mariana Spetea
Publikováno v:
Molecules, Vol 27, Iss 10, p 3140 (2022)
A few neurotransmitter systems have fascinated the research community, as muchas the opioid system (i.e., opioid ligands and their receptors) [...]
Externí odkaz:
https://doaj.org/article/3952b68698c8488d9ed4a88c755fe680
Autor:
Madeline R. Hennessy, Anna M. Gutridge, Alexander R. French, Elizabeth S. Rhoda, Yazan J. Meqbil, Meghna Gill, Yavnika Kashyap, Kevin Appourchaux, Barnali Paul, Zaijie Jim Wang, Richard M. van Rijn, Andrew P. Riley
Publikováno v:
Journal of Medicinal Chemistry. 66:3312-3326
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96bc9a3172c3f1ad575dad4ea2d6a2bc
https://doi.org/10.1021/acs.jmedchem.2c01707
https://doi.org/10.1021/acs.jmedchem.2c01707
Autor:
Yazan J. Meqbil, Hongyu Su, Robert J. Cassell, Kendall L. Mores, Anna M. Gutridge, Benjamin R. Cummins, Lan Chen, Richard M. van Rijn
Publikováno v:
Molecules, Vol 26, Iss 23, p 7236 (2021)
The δ-opioid receptor (δOR) holds great potential as a therapeutic target. Yet, clinical drug development, which has focused on δOR agonists that mimic the potent and selective tool compound SNC80 have largely failed. It has increasingly become ap
Externí odkaz:
https://doaj.org/article/c0f18744066941139e4bde05a78af626