Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms

Autor: Richard M. Salmon, Jingxu Guo, Jennifer H. Wood, Zhen Tong, John S. Beech, Aleksandra Lawera, Minmin Yu, David J. Grainger, Jill Reckless, Nicholas W. Morrell, Wei Li

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

The molecular basis of activin receptor-like kinase 1 (ALK1)-mediated endothelial bone morphogenetic protein (BMP) signalling is not fully understood. Here, the authors present crystal structures of the BMP10:ALK1 and prodomain-bound BMP9:ALK1 comple

Externí odkaz: https://doaj.org/article/c95928c8f6c04cf69fb1889c1608aeab

Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

Autor: Rebecca M. Baron, Lu Long, Kim Hoenderdos, Charlotte Summers, Paola Caruso, Nicholas W. Morrell, Ross D. King, Ivana Nikolic, Mark Southwood, Xudong Yang, Richard M. Salmon, Paul B. Yu, Geoffrey A. Bocobo, Sussan Nourshargh, Angelica Higuera, Wei Li, Katharine M Lodge, Zhen Tong, Alison M. Condliffe, Paul D. Upton, He Jiang, Edwin R. Chilvers, Peiran Yang

Publikováno v: American Journal of Respiratory and Critical Care Medicine

Rationale: Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome. Circulating BMP9 (bone morphogenetic protein 9) is emerging as an important regulator of pulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec89febd7613f32ecc49de59271d80a
https://pubmed.ncbi.nlm.nih.gov/33357019

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension

Autor: Christopher J. Rhodes, Allan Lawrie, Robert V. MacKenzie Ross, Mark Toshner, Mélanie Eyries, Werner Seeger, Richard M. Salmon, Stefano Ghio, Laura Scelsi, Stephen J. Wort, Gabor Kovacs, Florent Soubrier, J. Simon R. Gibbs, Richard C. Trembath, Jennifer M. Martin, Nicholas W. Morrell, Matthias Haimel, Gerry Coghlan, Marc Humbert, Jay Suntharalingam, Charaka Hadinnapola, Cesare Danesino, Willem H. Ouwehand, Louise C. Daugherty, Carmen M. Treacy, David G. Kiely, Andrea Olschewski, Joanna Pepke-Zaba, Deborah Whitehorn, Anton Vonk Noordegraaf, Andrew J. Peacock, Robin Condliffe, Horst Olschewski, Paul A. Corris, Joshua Hodgson, Hossein Ardeschir Ghofrani, Arjan C. Houweling, Colin Church, Jingxu Guo, Stefan Gräf, Barbara Girerd, Katherine Yates, Harm Jan Bogaard, Ivana Nikolic, Luke S. Howard, Henning Gall, Laura Southgate, Olga Shamardina, Emilia M. Swietlik, Marta Bleda, Rajiv D. Machado, Inga Prokopenko, John Wharton, James Liley, Simon Holden, Paul B. Yu, Martin R. Wilkins, Shahin Moledina, David Montani, Paul D. Upton, Wei Li

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2020, 201 (5), pp.575-585. ⟨10.1164/rccm.201906-1141OC⟩
Hodgson, J, Swietlik, E M, Salmon, R M, Hadinnapola, C, Nikolic, I, Wharton, J, Guo, J, Liley, J, Haimel, M, Bleda, M, Southgate, L, Machado, R D, Martin, J M, Treacy, C M, Yates, K, Daugherty, L C, Shamardina, O, Whitehorn, D, Holden, S, Bogaard, H J, Church, C, Coghlan, G, Condliffe, R, Corris, P A, Danesino, C, Eyries, M, Gall, H, Ghio, S, Ghofrani, H-A, Gibbs, J S R, Girerd, B, Houweling, A C, Howard, L, Humbert, M, Kiely, D G, Kovacs, G, Lawrie, A, MacKenzie Ross, R V, Moledina, S, Montani, D, Olschewski, A, Olschewski, H, Ouwehand, W H, Peacock, A J, Pepke-Zaba, J, Prokopenko, I, Rhodes, C J, Scelsi, L, Seeger, W, Soubrier, F, Suntharalingam, J, Toshner, M R, Trembath, R C, Vonk Noordegraaf, A, Wort, S J, Wilkins, M R, Yu, P B, Li, W, Gräf, S, Upton, P D & Morrell, N W 2020, ' Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 5, pp. 575-585 . https://doi.org/10.1164/rccm.201906-1141OC
American Journal of Respiratory and Critical Care Medicine, 201(5), 575-585. American Thoracic Society

International audience; Rationale: Recently, rare heterozygous mutations in GDF2 were identified in patients with pulmonary arterial hypertension (PAH). GDF2 encodes the circulating BMP (bone morphogenetic protein) type 9, which is a ligand for the B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7057d541ab94be4cf6a3450d45c90e47
https://hal.sorbonne-universite.fr/hal-02967807

Regulation of the ALK1 ligands, BMP9 and BMP10

Autor: Wei Li, Richard M. Salmon, Nicholas W. Morrell, He Jiang

Publikováno v: Biochemical Society Transactions. 44:1135-1141

Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1), a type I BMP receptor mainly expressed on vascular endothelial cells (ECs). ALK1-mediated BMP9/BMP10 signalling pathways have emerged as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff43c0660e851ee31237d0e521507e1e
https://doi.org/10.1042/bst20160083

S41 Characterisation of mutations in the gene encoding growth and differentiation factor 2 (GDF2) in patients with pulmonary arterial hypertension

Autor: Nicholas W. Morrell, John Wharton, Richard M. Salmon, Matthias Haimel, Joshua Hodgson, Wei Li, Stefan Gräf, Aleksandra Lawera, Martin R. Wilkins, Charaka Hadinnapola, Marta Bleda, Emilia M. Swietlik, Paul D. Upton

Publikováno v: Fundamental mechanisms of pulmonary arterial hypertension.

Most heritable cases of pulmonary arterial hypertension (PAH) are explained by mutations in BMPR2, which encodes the bone morphogenetic protein type 2 receptor (BMPR-II). Additionally, mutations in the endothelial type 1 receptor, ALK1, can cause PAH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c54ed8cb2122b6505cbcc6d0a976a3c5
https://doi.org/10.1136/thorax-2018-212555.47