Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Richard M, O'Brien"'
Autor:
Yong Kyung Kim, Jay A. Walters, Nicole D. Moss, Kristen L. Wells, Ryan Sheridan, Jose G. Miranda, Richard K.P. Benninger, Laura L. Pyle, Richard M. O'Brien, Lori Sussel, Howard W. Davidson
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101632- (2022)
Objective: Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection from type 2 diabetes (T2D). The current study examined whether ZnT
Externí odkaz:
https://doaj.org/article/1c21859e313c4bbbb1ba43957ea7e539
Autor:
Karin J. Bosma, Mohsin Rahim, James K. Oeser, Owen P. McGuinness, Jamey D. Young, Richard M. O'Brien
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101043- (2020)
Objective: G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycl
Externí odkaz:
https://doaj.org/article/4701c9a4aec148bc85868d0b7a48679f
Autor:
Matt Sinclair, Richard A Stein, Jonathan H Sheehan, Emily M Hawes, Richard M O’Brien, Emad Tajkhorshid, Derek P Claxton
Publikováno v:
bioRxiv
Mediating the terminal reaction of gluconeogenesis and glycogenolysis, the integral membrane protein G6PC1 regulates hepatic glucose production by catalyzing hydrolysis of glucose-6-phosphate within the lumen of the endoplasmic reticulum. Because G6P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e1ab1687e29263a064bcb2b88f9982
https://doi.org/10.1101/2023.03.13.532485
https://doi.org/10.1101/2023.03.13.532485
Autor:
Kayla A Boortz, Kristen E Syring, Lynley D Pound, Yingda Wang, James K Oeser, Richard M O'Brien
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162439 (2016)
Elevated fasting blood glucose (FBG) has been associated with increased risk for development of type 2 diabetes. Single nucleotide polymorphisms (SNPs) in G6PC2 are the most important common determinants of variations in FBG in humans. Studies using
Externí odkaz:
https://doaj.org/article/4d401ea920754e1d999df831d64728ed
Autor:
James K. Oeser, Owen P. McGuinness, Eric P. Skaar, Christopher A. Lopez, David R. Powell, Slavina B. Goleva, Lea K. Davis, Richard M. O'Brien, Kristen E. Syring, Karin J. Bosma, Kritika Singh
Publikováno v:
J Endocrinol
SLC30A8 encodes the zinc transporter ZnT8. SLC30A8 haploinsufficiency protects against type 2 diabetes (T2D), suggesting that ZnT8 inhibitors may prevent T2D. We show here that, while adult chow fed Slc30a8 haploinsufficient and knockout (KO) mice ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4cba74b458ce7a530559d7de40eaee
https://doi.org/10.1530/joe-20-0138
https://doi.org/10.1530/joe-20-0138
Publikováno v:
The Journal of Biological Chemistry
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) plays a critical role in hepatic glucose production during fasting by mediating the terminal step of the gluconeogenesis and glycogenolysis pathways. In concert with accessory transport proteins, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45301e5d4c36927c685c3789bb80f088
http://europepmc.org/articles/PMC8753184
http://europepmc.org/articles/PMC8753184
Autor:
Mohsin Rahim, Arya Y. Nakhe, Deveena R. Banerjee, Emily M. Overway, Karin J. Bosma, Jonah C. Rosch, James K. Oeser, Bo Wang, Ethan S. Lippmann, David A. Jacobson, Richard M. O'Brien, Jamey D. Young
Publikováno v:
The Journal of biological chemistry. 298(4)
Elevated fasting blood glucose (FBG) is associated with increased risks of developing type 2 diabetes (T2D) and cardiovascular-associated mortality. G6PC2 is predominantly expressed in islets, encodes a glucose-6-phosphatase catalytic subunit that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cefb077412870d3fdfdce04117a4182
https://pubmed.ncbi.nlm.nih.gov/35176280
https://pubmed.ncbi.nlm.nih.gov/35176280
Autor:
Karin J. Bosma, Richard K.P. Benninger, James K. Oeser, Jason D. Lee, Matthew E. Pamenter, Kristen E. Syring, Richard M. O'Brien
Publikováno v:
J Mol Evol
Pancreatic islet zinc levels vary widely between species. Very low islet zinc levels in Guinea pigs were thought to be driven by evolution of the INS gene that resulted in the generation of an isoform lacking a histidine at amino acid 10 in the B cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081bc22a4af71c7cdcb0d38eb1df5374
https://doi.org/10.1007/s00239-019-09898-0
https://doi.org/10.1007/s00239-019-09898-0
Publikováno v:
J Med Clin Res Rev
Background: Glucose-6-phosphatase-- β (3), one of multiple isoforms of glucose-6-phosphatase, catalyzes the final step in gluconeogenesis. It is known that mutated G6P3 is associated with severe neutropenia in addition to congenital heart defects, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efe44b33713226ac8dca068b4336b5b
https://doi.org/10.33425/2639-944x.1188
https://doi.org/10.33425/2639-944x.1188
Autor:
Owen P. McGuinness, James K. Oeser, Jamey D. Young, Karin J. Bosma, Richard M. O'Brien, Mohsin Rahim
Publikováno v:
Molecular Metabolism, Vol 41, Iss, Pp 101043-(2020)
Molecular Metabolism
Molecular Metabolism
Objective G6PC2 is predominantly expressed in pancreatic islet beta cells. G6PC2 hydrolyzes glucose-6-phosphate to glucose and inorganic phosphate, thereby creating a futile substrate cycle that opposes the action of glucokinase. This substrate cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee63edf033dbcb3dfd97e0b69febed0f
http://www.sciencedirect.com/science/article/pii/S2212877820301174
http://www.sciencedirect.com/science/article/pii/S2212877820301174