Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Richard M, Mortensen"'
Autor:
Ienglam Lei, Wei Huang, Peter A. Ward, Jordan S. Pober, George Tellides, Gorav Ailawadi, Francis D. Pagani, Andrew P. Landstrom, Zhong Wang, Richard M. Mortensen, Marilia Cascalho, Jeffrey Platt, Yuqing Eugene Chen, Hugo Yu Kor Lam, Paul C. Tang
Publikováno v:
Physiological Reports, Vol 9, Iss 17, Pp n/a-n/a (2021)
Abstract Background Dysfunction and inflammation of hearts subjected to cold ischemic preservation may differ between left and right ventricles, suggesting distinct strategies for amelioration. Methods and Results Explanted murine hearts subjected to
Externí odkaz:
https://doaj.org/article/2e9b05a8de9140b6b34e1adecaeeef81
Autor:
Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Xiang Xue, Melody Y. Zeng, Yinling Hu, Richard M. Mortensen, Joel K Greenson, Marilia Cascalho, Christiane E. Wobus, Justin A. Colacino, Gabriel Nunez, Liangyou Rui, Yatrik M. Shah
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet co
Externí odkaz:
https://doaj.org/article/7055cae8527e4457b716f2c0885ec9b1
Autor:
Jianrui Song, Ryan A. Frieler, Thomas M. Vigil, Jun Ma, Frank Brombacher, Sascha N. Goonewardena, Daniel R. Goldstein, Richard M. Mortensen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 13 (2021)
Background Hypertension‐induced cardiovascular remodeling is characterized by chronic low‐grade inflammation. Interleukin‐4 receptor α (IL‐4Rα) signaling is importantly involved in cardiovascular remodeling, however, the target cell type(s)
Externí odkaz:
https://doaj.org/article/9ba0de0fc14c4a3ca0c994c0d111207b
Autor:
Ienglam Lei, Wei Huang, Pierre Emmanuel Noly, Suyash Naik, Miriyam Ghali, Liu Liu, Francis D. Pagani, Ashraf Abou El Ela, Jordan S. Pober, Bertram Pitt, Jeffrey L. Platt, Marilia Cascalho, Zhong Wang, Y. Eugene Chen, Richard M. Mortensen, Paul C. Tang
Publikováno v:
Sci Transl Med
Preservation quality of donor hearts is a key determinant of transplant success. Preservation duration beyond 4 hours is associated with primary graft dysfunction (PGD). Given transport time constraints, geographical limitations exist for donor-recip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9766e94fbb166e32ddafe29d1c9b63b3
https://europepmc.org/articles/PMC10068866/
https://europepmc.org/articles/PMC10068866/
Autor:
Hideaki Inazumi, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takuro Numaga-Tomita, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Miku Oya, Miki Nonaka, Masami Sugihara, Hideyuki Kinoshita, Kenji Moriuchi, Hiromu Yanagisawa, Toshio Nishikimi, Hirohiko Motoki, Mitsuhiko Yamada, Sachio Morimoto, Kinya Otsu, Richard M. Mortensen, Kazuwa Nakao, Takeshi Kimura
Publikováno v:
Circulation Research. 130:234-248
Background: During the development of heart failure, a fetal cardiac gene program is reactivated and accelerates pathological cardiac remodeling. We previously reported that a transcriptional repressor, NRSF (neuron restrictive silencer factor), supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261c1a3c008ee35f30e1f9003dd00faf
https://doi.org/10.1161/circresaha.121.318898
https://doi.org/10.1161/circresaha.121.318898
Autor:
Ryan A. Frieler, Thomas M. Vigil, Jianrui Song, Christy Leung, Daniel R. Goldstein, Carey N. Lumeng, Richard M. Mortensen
Publikováno v:
Obesity (Silver Spring, Md.). 30(9)
The intersection between immunology and metabolism contributes to the pathogenesis of obesity-associated metabolic diseases as well as molecular control of inflammatory responses. The metabolite itaconate and the cell-permeable derivatives have robus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a4779831ce356198d7ed74c6f812f
https://pubmed.ncbi.nlm.nih.gov/35927796
https://pubmed.ncbi.nlm.nih.gov/35927796
Autor:
Yutein Chung, Jun Ma, Daniel R. Goldstein, Sascha N. Goonewardena, Thomas M. Vigil, Richard M. Mortensen, Frank Brombacher, Jianrui Song, Lindsey A. Muir, Carey N. Lumeng, Steven E. Whitesall, Ryan A. Frieler
Publikováno v:
Am J Physiol Heart Circ Physiol
Interleukin-4 receptor α (IL4Rα) signaling plays an important role in cardiac remodeling during myocardial infarction (MI). However, the target cell type(s) of IL4Rα signaling during this remodeling remains unclear. Here, we investigated the contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d066b3674407ab484de766646165abb
https://doi.org/10.1152/ajpheart.00251.2020
https://doi.org/10.1152/ajpheart.00251.2020
Autor:
Peter E O'Donnell, Xiu Zhen Ye, Melissa A DeChellis, Vannessa M Davis, Sheng Zhong Duan, Richard M Mortensen, David S Milstone
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160636 (2016)
Peroxisome proliferator activated receptor gamma (PPARγ) is a pleiotropic ligand activated transcription factor that acts in several tissues to regulate adipocyte differentiation, lipid metabolism, insulin sensitivity and glucose homeostasis. PPARγ
Externí odkaz:
https://doaj.org/article/fe1360a1884649e6b99b5b554bfbab27
Autor:
Hideaki, Inazumi, Koichiro, Kuwahara, Yasuaki, Nakagawa, Yoshihiro, Kuwabara, Takuro, Numaga-Tomita, Toshihide, Kashihara, Tsutomu, Nakada, Nagomi, Kurebayashi, Miku, Oya, Miki, Nonaka, Masami, Sugihara, Hideyuki, Kinoshita, Kenji, Moriuchi, Hiromu, Yanagisawa, Toshio, Nishikimi, Hirohiko, Motoki, Mitsuhiko, Yamada, Sachio, Morimoto, Kinya, Otsu, Richard M, Mortensen, Kazuwa, Nakao, Takeshi, Kimura
Publikováno v:
Circulation research. 130(2)
During the development of heart failure, a fetal cardiac gene program is reactivated and accelerates pathological cardiac remodeling. We previously reported that a transcriptional repressor, NRSF (neuron restrictive silencer factor), suppresses the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c264ddda6500583b3fb8b8fe26af8a6f
https://pubmed.ncbi.nlm.nih.gov/35050687
https://pubmed.ncbi.nlm.nih.gov/35050687
Autor:
Richard M. Mortensen, Christy Y. Y. Leung, Carey N. Lumeng, Ryan A. Frieler, Jianrui Song, Thomas M. Vigil
Publikováno v:
Obesity (Silver Spring)
Objective Excess dietary fat and sodium (NaCl) are both associated with obesity and metabolic dysfunction. In mice, high NaCl has been shown to block high-fat (HF) diet-induced weight gain. Here, the impact of an HF/NaCl diet on metabolic function in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60d02c8729d20e207494d2756a7a2c9
https://europepmc.org/articles/PMC8571049/
https://europepmc.org/articles/PMC8571049/