Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Richard M, Cawthon"'
Autor:
Svenja Pauleck, Biljana Gigic, Richard M. Cawthon, Jennifer Ose, Anita R. Peoples, Christy A. Warby, Jennifer A. Sinnott, Tengda Lin, Juergen Boehm, Petra Schrotz-King, Christopher I. Li, David Shibata, Erin M. Siegel, Jane C. Figueiredo, Adetunji T. Toriola, Martin Schneider, Alexis B. Ulrich, Albrecht Hoffmeister, Cornelia M. Ulrich, Sheetal Hardikar
Publikováno v:
J Geriatr Oncol
INTRODUCTION: Telomere shortening, as seen with aging, can cause chromosomal instability and promote cancer progression. We investigated the association between circulating telomere length and overall and disease-free survival in a sub-cohort of pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c24a38e6085f430c9f3bc52534dccb
https://doi.org/10.1016/j.jgo.2021.12.008
https://doi.org/10.1016/j.jgo.2021.12.008
In both mice and humans the misexpression of many genes lacking CpG islands (CGI- genes) increases with age, promoting inflammation and degenerative changes (Lee et al. 2021, ref. 1). In light of this recent discovery, we have revisited and expanded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0a0965dee66ce69783f7f4c86db00c6
https://doi.org/10.1101/2022.09.03.22279290
https://doi.org/10.1101/2022.09.03.22279290
Autor:
Gloria M. Petersen, Hugues Sicotte, Kari G. Rabe, Aminah Jatoi, William R. Bamlet, Lisa A. Boardman, Samuel O. Antwi, Ann L. Oberg, Brooke R. Druliner, Isoken Umudi, Richard M. Cawthon
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Leukocyte telomere length (LTL) has been associated with risk of multiple cancers, but its association with pancreatic ductal adenocarcinoma (PDAC) is unclear. We therefore investigated the association between peripheral blood LTL and PDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80985d3eacfffb93fae13ddd6ccc7b59
https://doi.org/10.1158/1055-9965.epi-19-1597
https://doi.org/10.1158/1055-9965.epi-19-1597
Autor:
Svenja Pauleck, Jennifer A. Sinnott, Yun-Ling Zheng, Shahinaz M. Gadalla, Richard Viskochil, Benjamin Haaland, Richard M. Cawthon, Albrecht Hoffmeister, Sheetal Hardikar
Publikováno v:
Cancers. 15:1159
(1) Background: Colorectal cancer risk and survival have previously been associated with telomere length in peripheral blood leukocytes and tumor tissue. A systematic review and meta-analysis of the literature was conducted. The PubMed, Embase, and W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::387ce91c7ed63060419651a530d43853
https://doi.org/10.3390/cancers15041159
https://doi.org/10.3390/cancers15041159
Autor:
Richard M. Cawthon, Stephanie J. Weinstein, Jarmo Virtamo, Madelyn Klugman, H. Dean Hosgood, Wei Hu, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Publikováno v:
Carcinogenesis
Disruption of ribosomal DNA (rDNA) has been linked to a variety of diseases in humans, including carcinogenesis. To evaluate the associations between rDNA copy number (CN) and risk of lung cancer, we measured 5.8S and 18S rDNA CN in the peripheral bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0100115723188be91dbed607334469bd
https://doi.org/10.1093/carcin/bgz052
https://doi.org/10.1093/carcin/bgz052
Autor:
R. Garrett Morgan, Lisa A. Lesniewski, Tam T. T. Phuong, Yu Liu, Daniel R. Machin, Kelly D. Reihl, Russell S. Richardson, Grant D. Henson, Daniel W. Trott, Eros Lazzerini Denchi, Samuel I. Bloom, Richard M. Cawthon, Anthony J. Donato, Ashley E. Walker
Publikováno v:
J Mol Cell Cardiol
Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343bec0ed9f8958bbe9d28f0d4d83a6b
https://doi.org/10.1016/j.yjmcc.2018.11.014
https://doi.org/10.1016/j.yjmcc.2018.11.014
Autor:
Aminah Jatoi, Richard M. Cawthon, Brooke R. Druliner, Kari G. Rabe, Hugues Sicotte, Ann L. Oberg, William R. Bamlet, Lisa A. Boardman, Gloria M. Petersen, Samuel O. Antwi, Amit Mahipal
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Critically shortened telomeres contribute to chromosomal instability and neoplastic transformation and are associated with early death of patients with certain cancer types. Shorter leukocyte telomere length (LTL) has been associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5d88e84ef6bfc0ff7584d666922429
https://europepmc.org/articles/PMC7855627/
https://europepmc.org/articles/PMC7855627/
Autor:
Richard M. Cawthon
Quantitative PCR is frequently used to measure average telomere length (TL) relative to the TL of a reference DNA sample of the investigator’s choosing. This makes comparisons of TLs across studies and laboratories difficult. Here we demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa0437dd3048909fb84d19b598b81e1
https://doi.org/10.1101/2020.06.24.169797
https://doi.org/10.1101/2020.06.24.169797
Autor:
Lynn B. Jorde, Aaron R. Quinlan, Melissa Dixon, Mark Leppert, Richard M. Cawthon, Elizabeth O'Brien, Thomas A Sasani, Lisa Baird, Huong Meeks, Andreas Peiffer, Ken R. Smith, Richard A. Kerber
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Ageing may be due to mutation accumulation across the lifespan, leading to tissue dysfunction, disease, and death. We tested whether germline autosomal mutation rates in young adults predict their remaining survival, and, for women, their reproductiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9901834d21b98fbbb41e85193521cd74
https://pubmed.ncbi.nlm.nih.gov/32561805
https://pubmed.ncbi.nlm.nih.gov/32561805
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34746 (2012)
Although there is abundant evidence that human longevity is heritable, efforts to map loci responsible for variation in human lifespan have had limited success.We identified individuals from a large multigenerational population database (the Utah Pop
Externí odkaz:
https://doaj.org/article/ca6c1700dc8244f2adec92aa68a2ed12