Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

Autor: Christopher A Maxwell, Javier Benítez, Laia Gómez-Baldó, Ana Osorio, Núria Bonifaci, Ricardo Fernández-Ramires, Sylvain V Costes, Elisabet Guinó, Helen Chen, Gareth J R Evans, Pooja Mohan, Isabel Català, Anna Petit, Helena Aguilar, Alberto Villanueva, Alvaro Aytes, Jordi Serra-Musach, Gad Rennert, Flavio Lejbkowicz, Paolo Peterlongo, Siranoush Manoukian, Bernard Peissel, Carla B Ripamonti, Bernardo Bonanni, Alessandra Viel, Anna Allavena, Loris Bernard, Paolo Radice, Eitan Friedman, Bella Kaufman, Yael Laitman, Maya Dubrovsky, Roni Milgrom, Anna Jakubowska, Cezary Cybulski, Bohdan Gorski, Katarzyna Jaworska, Katarzyna Durda, Grzegorz Sukiennicki, Jan Lubiński, Yin Yao Shugart, Susan M Domchek, Richard Letrero, Barbara L Weber, Frans B L Hogervorst, Matti A Rookus, J Margriet Collee, Peter Devilee, Marjolijn J Ligtenberg, Rob B van der Luijt, Cora M Aalfs, Quinten Waisfisz, Juul Wijnen, Cornelis E P van Roozendaal, HEBON, EMBRACE, Douglas F Easton, Susan Peock, Margaret Cook, Clare Oliver, Debra Frost, Patricia Harrington, D Gareth Evans, Fiona Lalloo, Rosalind Eeles, Louise Izatt, Carol Chu, Diana Eccles, Fiona Douglas, Carole Brewer, Heli Nevanlinna, Tuomas Heikkinen, Fergus J Couch, Noralane M Lindor, Xianshu Wang, Andrew K Godwin, Maria A Caligo, Grazia Lombardi, Niklas Loman, Per Karlsson, Hans Ehrencrona, Anna von Wachenfeldt, SWE-BRCA, Rosa Bjork Barkardottir, Ute Hamann, Muhammad U Rashid, Adriana Lasa, Trinidad Caldés, Raquel Andrés, Michael Schmitt, Volker Assmann, Kristen Stevens, Kenneth Offit, João Curado, Hagen Tilgner, Roderic Guigó, Gemma Aiza, Joan Brunet, Joan Castellsagué, Griselda Martrat, Ander Urruticoechea, Ignacio Blanco, Laima Tihomirova, David E Goldgar, Saundra Buys, Esther M John, Alexander Miron, Melissa Southey, Mary B Daly, BCFR, Rita K Schmutzler, Barbara Wappenschmidt, Alfons Meindl, Norbert Arnold, Helmut Deissler, Raymonda Varon-Mateeva, Christian Sutter, Dieter Niederacher, Evgeny Imyamitov, Olga M Sinilnikova, Dominique Stoppa-Lyonne, Sylvie Mazoyer, Carole Verny-Pierre, Laurent Castera, Antoine de Pauw, Yves-Jean Bignon, Nancy Uhrhammer, Jean-Philippe Peyrat, Philippe Vennin, Sandra Fert Ferrer, Marie-Agnès Collonge-Rame, Isabelle Mortemousque, GEMO Study Collaborators, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, Sue Healey, kConFab, Mary Helen Barcellos-Hoff, Marc Vidal, Stephen B Gruber, Conxi Lázaro, Gabriel Capellá, Lesley McGuffog, Katherine L Nathanson, Antonis C Antoniou, Georgia Chenevix-Trench, Markus C Fleisch, Víctor Moreno, Miguel Angel Pujana

Publikováno v: PLoS Biology, Vol 9, Iss 11, p e1001199 (2011)

Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased ri

Externí odkaz: https://doaj.org/article/6b575e23a5b6401b9e491335b8001395

Suppementary Table 4 from Tumor Genetic Analyses of Patients with Metastatic Melanoma Treated with the BRAF Inhibitor Dabrafenib (GSK2118436)

Autor: Georgina V. Long, Richard Kefford, Peter F. Lebowitz, Martin Curtis, Robert Gagnon, Bo Ma, Michael A. Davies, Anna Pavlick, Michael P. Brown, Michael Millward, Hendrik-Tobias Arkenau, Gerald S. Falchook, Jeffrey R. Infante, Steven O'Day, Kurt D'Andrea, Richard Letrero, Joel Greshock, Bradley Wubbenhorst, Anne-Marie Martin, Katherine L. Nathanson

Suppementary Table 4 - PDF file 38K, Correlation analysis of selected genes from aCGH data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858c8d80effae65e1f2b10d9b7dca015
https://doi.org/10.1158/1078-0432.22450226.v1

Supplementary Table 2 from Tumor Genetic Analyses of Patients with Metastatic Melanoma Treated with the BRAF Inhibitor Dabrafenib (GSK2118436)

Autor: Georgina V. Long, Richard Kefford, Peter F. Lebowitz, Martin Curtis, Robert Gagnon, Bo Ma, Michael A. Davies, Anna Pavlick, Michael P. Brown, Michael Millward, Hendrik-Tobias Arkenau, Gerald S. Falchook, Jeffrey R. Infante, Steven O'Day, Kurt D'Andrea, Richard Letrero, Joel Greshock, Bradley Wubbenhorst, Anne-Marie Martin, Katherine L. Nathanson

Supplementary Table 2 - PDF file 42K, Correlation of PTEN immunohistochemistry and PTEN mutation/copy number status

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4cb775379897c7f7d4f2fad5ee0e8e
https://doi.org/10.1158/1078-0432.22450211.v1

Data from Tumor Genetic Analyses of Patients with Metastatic Melanoma Treated with the BRAF Inhibitor Dabrafenib (GSK2118436)

Autor: Georgina V. Long, Richard Kefford, Peter F. Lebowitz, Martin Curtis, Robert Gagnon, Bo Ma, Michael A. Davies, Anna Pavlick, Michael P. Brown, Michael Millward, Hendrik-Tobias Arkenau, Gerald S. Falchook, Jeffrey R. Infante, Steven O'Day, Kurt D'Andrea, Richard Letrero, Joel Greshock, Bradley Wubbenhorst, Anne-Marie Martin, Katherine L. Nathanson

Purpose: Dabrafenib is a selective inhibitor of V600-mutant BRAF kinase, which recently showed improved progression-free survival (PFS) as compared with dacarbazine, in metastatic melanoma patients. This study examined potential genetic markers assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c834bb070142a1c0fe1ff249a242261a
https://doi.org/10.1158/1078-0432.c.6521879

Supplementary Methods from Tumor Genetic Analyses of Patients with Metastatic Melanoma Treated with the BRAF Inhibitor Dabrafenib (GSK2118436)

Autor: Georgina V. Long, Richard Kefford, Peter F. Lebowitz, Martin Curtis, Robert Gagnon, Bo Ma, Michael A. Davies, Anna Pavlick, Michael P. Brown, Michael Millward, Hendrik-Tobias Arkenau, Gerald S. Falchook, Jeffrey R. Infante, Steven O'Day, Kurt D'Andrea, Richard Letrero, Joel Greshock, Bradley Wubbenhorst, Anne-Marie Martin, Katherine L. Nathanson

Supplementary Methods - PDF file 95K, Supplementary Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467c6f7cb3cf32a3ee047b261f92ed52
https://doi.org/10.1158/1078-0432.22450217.v1