Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Richard Labaudiniere"'
Autor:
Shuhong Sun, Chao Wang, Pei Zhao, Gabe Kline, Julia Grandjean, Xin Jiang, Richard Labaudiniere, R. Luke Wiseman, Jeffery W. Kelly, William E. Balch
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ab430185210a1c2c1893badfe00d590
https://doi.org/10.2139/ssrn.4207576
https://doi.org/10.2139/ssrn.4207576
Autor:
Shuhong Sun, Chao Wang, Pei Zhao, Gabe M. Kline, Julia M.D. Grandjean, Xin Jiang, Richard Labaudiniere, R. Luke Wiseman, Jeffery W. Kelly, William E. Balch
Publikováno v:
Cell Chemical Biology. 30:22-42.e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b966a03e775c3d17b813b1a0b4a87f5
https://doi.org/10.1016/j.chembiol.2022.12.004
https://doi.org/10.1016/j.chembiol.2022.12.004
Autor:
Shelley Darnbrough, Christopher J. Burns, Kathleen Burke, Isabelle Morize, Stephen M. Condon, Joanne Uhl, Navinchandra U Jariwala, Mark Bobko, Richard Labaudiniere
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:731-736
A series of conformationally-restricted analogues of hPTH was prepared, based on the parent peptide agonist, cyclo(Lys(18)-Asp(22))[Ala(1),Nle(8),Lys(18),Asp(22),Leu(27)]hPTH(1-31)NH(2) (2, EC(50)=0.29nM). Truncation of 2 at either the N- or C-termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bdd8cabc827b993ac44df99bc8d5ac
https://doi.org/10.1016/s0968-0896(01)00335-2
https://doi.org/10.1016/s0968-0896(01)00335-2
Publikováno v:
Journal of Combinatorial Chemistry. 2:600-603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3bbae1c960623e2c7f6883150a9ec3
https://doi.org/10.1021/cc0000444
https://doi.org/10.1021/cc0000444
Autor:
Timothy F. Herpin, Katy G. Van Kirk, and Sheng Tang Yu, Salvino Joseph M, Richard Labaudiniere
Publikováno v:
Journal of Combinatorial Chemistry. 2:513-521
The solid-phase synthesis of a 10,000 member combinatorial library of 1,5-benzodiazepine-2-one derivatives is reported. The 3-amino-1,5-benzodiazepine-2-one scaffold was prepared in solution, and the benzamide nitrogen was used as a point of attachme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e603f0547db4f819940c1b7b9e63f8dd
https://doi.org/10.1021/cc000025u
https://doi.org/10.1021/cc000025u
Publikováno v:
Tetrahedron Letters. 41:3029-3033
A new solid-phase efficient route to 1,5-benzothiazepine-4-one derivatives is reported. The synthesis exploits the variety of halo-nitrobenzene derivatives available and the facile substitution of the benzamide nitrogen. A wide range of derivatives c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8394417a4b3ffb5b5f78564818296b88
https://doi.org/10.1016/s0040-4039(00)00341-5
https://doi.org/10.1016/s0040-4039(00)00341-5
Autor:
and N. Vasant Kumar, Stephen M. Condon, Bruce Miller, Navinchandra U Jariwala, Kathleen Burke, Richard Labaudiniere, Isabelle Morize, Christopher J. Burns, Joanne Uhl, Shelley Darnbrough, Kenneth Locke, Krolikowski P
Publikováno v:
Journal of the American Chemical Society. 122:3007-3014
Conformational restrictions in the form of [i, i + 4] lactam bridges were sequentially incorporated into the shortest fragment of hPTH with recognized efficacy in the OVX rat model of osteoporosis,...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2734f796782ef2fb246e83f160ac765
https://doi.org/10.1021/ja994033u
https://doi.org/10.1021/ja994033u
Autor:
Liang Ma, Marie Pierre Cherrier, Richard Labaudiniere, Joseph J. Romano, Morton George C, Christopher Hulme, Celine Duquenne, Salvino Joseph M
Publikováno v:
Tetrahedron Letters. 41:1883-1887
This communication reveals a novel application of the so-called convertible isonitriles for the solution/solid phase generation of γ-lactam analogues. Use of tethered N-BOC aldehydes in the Ugi multi-component reaction (MCR), followed by BOC removal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::390a4ec50241504b63e2f9e34d3b8f76
https://doi.org/10.1016/s0040-4039(00)00052-6
https://doi.org/10.1016/s0040-4039(00)00052-6
Autor:
Andrew Allen, Liang Ma, N.Vasant Kumar, Richard Labaudiniere, Krolikowski P, Christopher Hulme
Publikováno v:
Tetrahedron Letters. 41:1509-1514
This communication reveals a novel application of resin bound α-amino acids coupled with the UDC (Ugi/DeBOC/cyclize) strategy. Reaction with either N -BOC-α-amino aldehydes or N -BOC anthranilic acids and subsequent acid treatment allows the prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f86c8e6e76024f4e56376a9b2c56d6
https://doi.org/10.1016/s0040-4039(99)02326-6
https://doi.org/10.1016/s0040-4039(99)02326-6
Autor:
Sheng Yuh Tang, Salvino Joseph M, Richard Labaudiniere, Joseph J. Romano, Liang Ma, Morton George C, Marie Pierre Cherrier, Christopher Hulme, Steve Choi
Publikováno v:
Tetrahedron Letters. 41:1889-1893
This communication reveals novel applications of the CO2/MeOH reagent combination coupled with the UDC (Ugi/DeBOC/Cyclize) strategy. The Ugi five component condensation (5CC) affords carbamate protected amino-amides in good yield. When one of the sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22e2e5b1007c9a594dc08e2be046684f
https://doi.org/10.1016/s0040-4039(00)00053-8
https://doi.org/10.1016/s0040-4039(00)00053-8