Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Richard Labaudinière"'
Autor:
Cecília Monteiro, Xin Jiang, Marta Novais, Richard Labaudinière, Jeffery W. Kelly, Teresa Coelho, Joel N. Buxbaum
Publikováno v:
Proc Natl Acad Sci U S A
The transthyretin (TTR) amyloidoses (ATTR) are progressive, degenerative diseases resulting from dissociation of the TTR tetramer to monomers, which subsequently misfold and aggregate, forming a spectrum of aggregate structures including oligomers an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746f1965f25148899da4e0ff2fbb2b09
https://doi.org/10.1073/pnas.2016072118
https://doi.org/10.1073/pnas.2016072118
Autor:
Richard Labaudinière, Pedro Trigo, Isabel Conceição, Jeffery W. Kelly, Ana Martins da Silva, Jason L. Chan, Donna R. Grogan, Jeff Packman, Ole B. Suhr, Márcia Waddington Cruz, Teresa Coelho, Hartmut Schmidt, Luis F. Maia, Violaine Planté-Bordeneuve
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Journal of Neurology
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Journal of Neurology
Tafamidis, a transthyretin (TTR) kinetic stabilizer, delayed neuropathic progression in patients with Val30Met TTR familial amyloid polyneuropathy (TTR-FAP) in an 18-month randomized controlled trial (study Fx-005). This 12-month, open-label extensio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd3595b64cc7fe9336c7ccf2e735698
https://doi.org/10.1007/s00415-013-7051-7
https://doi.org/10.1007/s00415-013-7051-7
Autor:
Christine Bulawa, Teresa Coelho, Ilise Lombardo, Steve Riley, Giampaolo Merlini, Jeffery W. Kelly, Richard Labaudinière, Mathew S. Maurer, Rajiv Mundayat, Daniel P. Judge, Violaine Planté-Bordeneuve, James Fleming, Pedro E. Huertas
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Neurology and Therapy
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Neurology and Therapy
Transthyretin (TTR) transports the retinol-binding protein–vitamin A complex and is a minor transporter of thyroxine in blood. Its tetrameric structure undergoes rate-limiting dissociation and monomer misfolding, enabling TTR to aggregate or to bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441a1b2299082813f2febb4e63362515
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
Autor:
Lan Wang, Richard Labaudinière, Michael Devit, James Fleming, Stephen Connelly, Ted R. Foss, Jeffery W. Kelly, Evan T. Powers, R. Luke Wiseman, Jeff Packman, Ian A. Wilson, Charlotte Weigel, Christine Bulawa
Publikováno v:
Proceedings of the National Academy of Sciences. 109:9629-9634
The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive neuropathy and/or cardiomyopathy. ATTR are caused by aggregation of transthyretin (TTR), a natively tetrameric protein involved in the transport of thyrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962f4c6fff550d7ef08722df25bae93f
https://doi.org/10.1073/pnas.1121005109
https://doi.org/10.1073/pnas.1121005109
Autor:
Richard Labaudinière
Publikováno v:
Orphan Drugs and Rare Diseases ISBN: 9781849738064
Rare genetic diseases represent a unique opportunity to develop drugs on genetically validated targets and fulfil major unmet medical needs. A genetically validated target improves the chance of positive clinical outcome, a significant hurdle for hal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::118da74044c7d28166c6960cebfb50e1
https://doi.org/10.1039/9781782624202-00202
https://doi.org/10.1039/9781782624202-00202
Autor:
Richard, Labaudinière
Publikováno v:
Current opinion in molecular therapeutics. 4(6)
Genetic variations are playing an increasing role in drug discovery, particularly in disease-specific drug target identification and in drug candidate profiling to predict drug response in genetically heterogeneous patient populations. Recently, gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4c05c25f12d10cac1775d43f63a023e
https://pubmed.ncbi.nlm.nih.gov/12596357
https://pubmed.ncbi.nlm.nih.gov/12596357
Publikováno v:
Synthetic Communications. 11:423-428
In the course of our work on umpolung of α,β-ethylenic ketones and aldehydes1, the use of thioacetalised γ-ketophosphonium salts and ylids led us to investigate the hydrolysis of 1,3-dithianes. Among the known methods of removal of thioacetal prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c123280df90c1a43f888bbe2f735e7
https://doi.org/10.1080/00397918108061872
https://doi.org/10.1080/00397918108061872