Zobrazeno 1 - 10
of 606
pro vyhledávání: '"Richard L. Simmons"'
Autor:
Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-11 (2021)
Abstract Background Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response. Methods Using network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level
Externí odkaz:
https://doaj.org/article/661d12bce8a244c99e15f56f6542a73d
Autor:
Nabil Azhar, Rami A. Namas, Khalid Almahmoud, Akram Zaaqoq, Othman A. Malak, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Andrew Abboud, Richard L. Simmons, Ruben Zamora, Timothy R. Billiar, Yoram Vodovotz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients
Externí odkaz:
https://doaj.org/article/eaee90484a5b42d6b93c66d1d070bc50
Autor:
Christof Kaltenmeier, Hamza O. Yazdani, Kristin Morder, David A. Geller, Richard L. Simmons, Samer Tohme
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
While neutrophil extracellular traps (NETs) are important for directly promoting cancer growth, little is known about their impact on immune cells within the tumor microenvironment (TME). We hypothesize that NETs can directly interact with infiltrati
Externí odkaz:
https://doaj.org/article/5348aaf05b064dc9b2d68480273e0038
Publikováno v:
Cancers, Vol 13, Iss 23, p 6131 (2021)
Metastasis is the leading cause of cancer related morbidity and mortality. The metastatic process involves several identifiable biological stages, including tumor cell dissemination, intravasation, and the extravasation of circulating cancer cells to
Externí odkaz:
https://doaj.org/article/95a2b2c1739d4ae5a16155eebe082967
Autor:
Hongji Zhang, Julie Goswami, Patrick Varley, Dirk J. van der Windt, Jinghua Ren, Patricia Loughran, Hamza Yazdani, Matthew D. Neal, Richard L. Simmons, Jinxiang Zhang, Allan Tsung, Hai Huang
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Innate immunity can initiate platelet activation during the development of thrombosis through a process, termed immunothrombosis. Neutrophils form neutrophil extracellular traps (NETs) that have been shown to interact directly with platelets and play
Externí odkaz:
https://doaj.org/article/9314d5508361467d826997a44ad59949
Autor:
Dongmei Liu, Rami A. Namas, Yoram Vodovotz, Andrew B. Peitzman, Richard L. Simmons, Hong Yuan, Qi Mi, Timothy R. Billiar
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Purpose: We sought to identify a MODS score parameter that highly correlates with adverse outcomes and then use this parameter to test the hypothesis that multiple severity-based MODS clusters could be identified after blunt trauma.Methods: MOD score
Externí odkaz:
https://doaj.org/article/9facb1ed0dd9402fa354ee00b837fab1
Autor:
Yoram Vodovotz, Richard L. Simmons, Chandrashekhar R. Gandhi, Derek Barclay, Bahiyyah S. Jefferson, Chao Huang, Rami Namas, Fayten el-Dehaibi, Qi Mi, Timothy R. Billiar, Ruben Zamora
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
We hypothesized that isolated primary mouse hepatic stellate cells (HSC) and hepatocytes (HC) would elaborate different inflammatory responses to hypoxia with or without reoxygenation. We further hypothesized that intracellular information processing
Externí odkaz:
https://doaj.org/article/b95f5dfa3217401d8be4c22adaa36c19
Autor:
Allan Tsung, Hai Huang, Richard L. Simmons, Yanming Wang, Kerri Mowen, Patricia Loughran, Alexis P. Chidi, Ahmed B. Al-Khafaji, Hamza O. Yazdani, Samer Tohme
Legends for Supplementary Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059408736560f3fcfdc981aebcb3d408
https://doi.org/10.1158/0008-5472.22410336
https://doi.org/10.1158/0008-5472.22410336
Data from Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth
Autor:
Samer Tohme, Richard L. Simmons, Tai Sheng, Allan Tsung, David L. Bartlett, David A. Geller, Sruti Shiva, Patricia Loughran, Hai Huang, Hongji Zhang, Dirk J. van der Windt, Alexander J. Comerci, Eva Roy, Hamza O. Yazdani
Neutrophil infiltration and neutrophil extracellular traps (NET) in solid cancers are associated with poorer prognosis, but the mechanisms are incompletely understood. We hypothesized that NETs enhance mitochondrial function in tumor cells, providing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477e674236a7d232de81923c1977d0d3
https://doi.org/10.1158/0008-5472.c.6512394
https://doi.org/10.1158/0008-5472.c.6512394
Autor:
Allan Tsung, Hai Huang, Richard L. Simmons, Yanming Wang, Kerri Mowen, Patricia Loughran, Alexis P. Chidi, Ahmed B. Al-Khafaji, Hamza O. Yazdani, Samer Tohme
Supplementary Figure 1. Flow cytometric analysis of purity of neutrophil isolation technique from bone marrow of mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c560ec92d2b48d5acfd21fb9002f0d6
https://doi.org/10.1158/0008-5472.22410342.v1
https://doi.org/10.1158/0008-5472.22410342.v1