Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Richard L. Leff"'
Autor:
Andrew Griffin, Stuart Hossack, Richard L. Leff, Dan A. Chiche, Philippe Walker, Roxane Aubray, William Brown
Publikováno v:
The Journal of Pain. 18:726-738
Most previous transient receptor potential vanilloid subtype 1 (TRPV1) antagonist programs have been put on hold, mainly because of on-target adverse events: hyperthermia and impaired noxious heat sensation. NEO6860 is a TRPV1 antagonist, blocking ca
Autor:
Richard L. Leff, Jeffrey Miller, Philippe Walker, Pierre Arsenault, Roi Treister, Nathaniel P. Katz, William Brown, Dan A. Chiche
Publikováno v:
Pain Reports
PAIN Reports, Vol 3, Iss 6, p e696 (2018)
PAIN Reports, Vol 3, Iss 6, p e696 (2018)
Introduction:. NEO6860 is a TRPV1 antagonist when activated by capsaicin but not by heat or pH, developed to relieve pain without the adverse events reported with non–modality-selective TRPV1 antagonists. Objective:. The primary Objective of this s
Autor:
Kurt D. Petschke, Richard L. Leff, Einar Ingvarsson, Ange Zhou, Kevin C. O’Connor, Donald K. K. Lee, Seth Richards-Shubik, A. David Paltiel, Richard Nowak, Martin Shubik
Publikováno v:
Muscle & Nerve. 52:527-533
Introduction: Few studies of the demographics, natural history, and clinical management of inclusion body myo- sitis (IBM) have been performed in a large patient population. To more accurately define these characteristics, we developed and distribute
Autor:
Ilona Steigerwald, Michael S. Leong, Andrew S.C. Rice, Mark S. Wallace, Bernard Ravina, Dennis C. Turk, John T. Farrar, Robert H. Dworkin, Ralf Baron, Stephen Senn, Robert D. Kerns, Christine Rauschkolb, Cyrus R. Mehta, Cristina Sampaio, Joseph W. Stauffer, Charles Taylor, Søren H. Sindrup, Marc R. Gastonguay, Jennifer S. Gewandter, Raymond A. Dionne, Paul J. Desjardins, Karin L. Petersen, Rozalina Dimitrova, Smriti Iyengar, Eija Kalso, Rolf-Detlef Treede, David J. Hewitt, Srinivasa N. Raja, Jonathan Stewart, Nathaniel P. Katz, Penney Cowan, Richard E. White, Ian Gilron, Richard L. Leff, Jeffrey Tobias, Michael P. McDermott, Michael C. Rowbotham, Gary W. Jay
Publikováno v:
Gewandter, J S, Dworkin, R H, Turk, D C, McDermott, M P, Baron, R, Gastonguay, M R, Gilron, I, Katz, N P, Mehta, C, Raja, S N, Senn, S, Taylor, C, Cowan, P, Desjardins, P, Dimitrova, R, Dionne, R, Farrar, J T, Hewitt, D J, Iyengar, S, Jay, G W, Kalso, E, Kerns, R D, Leff, R, Leong, M, Petersen, K, Ravina, B M, Rauschkolb, C, Rice, A S C, Rowbotham, M C, Sampaio, C, Sindrup, S H, Stauffer, J W, Steigerwald, I, Stewart, J, Tobias, J, Treede, R-D, Wallace, M & White, R E 2014, ' Research designs for proof-of-concept chronic pain clinical trials : IMMPACT recommendations ', Pain, vol. 155, no. 9, pp. 1683–1695 . https://doi.org/10.1016/j.pain.2014.05.025
Pain, vol 155, iss 9
Pain, vol 155, iss 9
Proof-of-concept (POC) clinical trials play an important role in developing novel treatments and determining whether existing treatments may be efficacious in broader populations of patients. The goal of most POC trials is to determine whether a trea
Autor:
Jeanne E. Hicks, Elizabeth Adams, Frederick W. Miller, Paul H. Plotz, Jeffrey B. Sherman, Suzanne H. Burgess, Mark F. Gourley, Bonnie C. Thornton, Lourdes Villalba, Richard L. Leff
Publikováno v:
Arthritis & Rheumatism. 41:392-399
Objective To assess the clinical usefulness of 2 novel therapies for treatment-resistant myositis. Methods Thirty patients with refractory myositis, of whom 25 had an inadequate or no response to previous cytotoxic therapy, were randomized to begin e
Publikováno v:
Cleveland Clinic Journal of Medicine. 62:51-61
BACKGROUND Raynaud9s phenomenon, an episodic vascular disorder induced by cold temperatures or stress and characterized by white, blue, and red discoloration of the fingers and toes, may affect up to 20% of the general population. KEY POINTS Raynaud9
Autor:
Peter McPhie, Vaidehi Sridhar, Jan Dohlman, Nina Raben, Richard L. Leff, C.Craig Hyde, Ralph C. Nichols, Paul H. Plotz
Publikováno v:
Journal of Biological Chemistry. 269:24277-24283
In myositis, disease-specific autoantibodies may be directed against an aminoacyl-tRNA synthetase, usually histidyl-tRNA synthetase. To explore the basis for this phenomenon, we have made recombinant histidyl-tRNA synthetase in the baculovirus system
Autor:
Richard L. Leff, Dennis M. Klinman
Publikováno v:
ImmunoMethods. 1:169-176
Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, polymyositis, myasthenia gravis, and Hashimoto's thyroiditis result from abnormalities in immune regulation culminating in the stimulation of autoreactive lymphocytes. Th
Autor:
Richard L. Leff, Robert Wesley, Marinos C. Dalakas, D. D. Fraser, Susan F. Leitman, Jeanne E. Hicks, Frederick W. Miller, Cronin Me, Paul H. Plotz
Publikováno v:
New England Journal of Medicine. 326:1380-1384
Background The therapeutic options for patients with polymyositis or dermatomyositis that is resistant to corticosteroids are limited, unproved, and often toxic. Uncontrolled trials concluded that both plasma exchange and leukapheresis are beneficial
Autor:
J Chris, Buckland-Wright, Rupert J, Ward, Charles, Peterfy, Christopher F, Mojcik, Richard L, Leff
Publikováno v:
The Journal of rheumatology. 31(8)
To determine the baseline and longitudinal consistency in reproducibility of the semiflexed metatarsophalangeal (MTP) position in repeat examinations of patients with knee osteoarthritis (OA) recruited for a multicenter clinical trial that terminated