Výsledky vyhledávání - "Richard L. Lawler"

Relevance of Plasma Matrix Metalloproteinase-9 for Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation

Autor: Guang-Shing Cheng, Mary E.D. Flowers, Mukta Arora, Kirsten M. Williams, Paul J. Martin, Ted Gooley, Lynn Onstad, Iskra Pusic, Yoshihiro Inamoto, Joseph Pidala, Stephanie J. Lee, Vincent T. Ho, Richard L. Lawler, John A. Hansen

Publikováno v: Transplant Cell Ther

Bronchiolitis obliterans syndrome (BOS) is a highly morbid form of chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). Several plasma proteins have been identified as biomarkers for BOS after lung trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69a21707cb77c82ea154a6540dbaa41
https://doi.org/10.1016/j.jtct.2021.06.006

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Autor: Joseph Pidala, Amin Momin, Stephanie J. Lee, Samir M. Hanash, John A. Hansen, Richard L. Lawler, Paul J. Martin, Lynn Onstad, Yoshihiro Inamoto, Laura Tabellini, Mary E.D. Flowers, Hiroyuki Katayama

Publikováno v: Blood Adv

To identify plasma biomarkers associated with fibrotic mechanisms of chronic graft-versus-host disease (GVHD), we used multiplex mass spectrometry with pooled samples for biomarker discovery in comparing proteomic profiles between patients with newly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c03551197f8bdcc472423b6bb15b89
https://pubmed.ncbi.nlm.nih.gov/32492155

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Inflammatory Cytokine Profile in Individuals with Inherited Chromosomally Integrated Human Herpesvirus 6

Autor: Danielle M. Zerr, Meei-Li Huang, Joshua A. Hill, Richard L. Lawler, Daniel P. Weschke, Terry Stevens-Ayers, John A. Hansen, Michael Boeckh, Keith R. Jerome, Wendy M. Leisenring

Publikováno v: Biol Blood Marrow Transplant

Acute graft-versus-host-disease (aGVHD) is a major complication following hematopoietic cell transplantations (HCTs). We have shown that HCT recipients in whom either the donor or patient had inherited chromosomally integrated human herpesvirus 6 (ic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fb9484208035f612fc05cb78ca92c0
https://pubmed.ncbi.nlm.nih.gov/31678540

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Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment

Autor: Paul J. Martin, Laura Tabellini, John A. Hansen, Barry E. Storer, George B. McDonald, Richard L. Lawler

Publikováno v: Blood. 126:113-120

We identified plasma biomarkers that presaged outcomes in patients with gastrointestinal graft-versus-host disease (GVHD) by measuring 23 biomarkers in samples collected before initiation of treatment. Six analytes with the greatest accuracy in predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db4288a7bf6360718bbc90f8e35dd1a
https://doi.org/10.1182/blood-2015-03-636753

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Predictive Value of Clinical Findings and Plasma Biomarkers after Fourteen Days of Prednisone Treatment for Acute Graft-versus-host Disease

Autor: Laura Tabellini, Barry E. Storer, H. Gary Schoch, Paul J. Martin, Steven L. Rosinski, John A. Hansen, Richard L. Lawler, George B. McDonald

Publikováno v: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 23(8)

We examined the hypothesis that plasma biomarkers and concomitant clinical findings after initial glucocorticoid therapy can accurately predict failure of graft-versus-host-disease (GVHD) treatment and mortality. We analyzed plasma samples and clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adc4048ea00569e517c8e1b409cbea6
https://pubmed.ncbi.nlm.nih.gov/28478120

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A Novel Soluble Form of Tim-3 Associated with Severe Graft-versus-Host Disease

Autor: Laura Tabellini, Bryan M. Grogan, George B. McDonald, Richard L. Lawler, John A. Hansen, Samir M. Hanash, Chee Hong Wong, Barry E. Storer, Paul J. Martin, Chris Baik, Alice Chin, Melissa M. Johnson, Qing Zhang

Publikováno v: Biology of Blood and Marrow Transplantation. 19(9):1323-1330

The T cell Ig and mucin domain 3 (Tim-3) receptor has been implicated as a negative regulator of adaptive immune responses. We have utilized a proteomic strategy to identify novel proteins associated with graft versus host disease (GVHD) after alloge

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Changes in the Vaginal Microenvironment with Metronidazole Treatment for Bacterial Vaginosis in Early Pregnancy

Autor: Kathy Agnew, Jennifer E. Balkus, Richard L. Lawler, Jane Hitti, Caroline M. Mitchell

Publikováno v: Journal of Women's Health. 18:1817-1824

Bacterial vaginosis (BV) is associated with preterm delivery, but there is little evidence that treatment improves pregnancy outcomes. We examined whether oral or vaginal metronidazole treatment for BV in early pregnancy was more effective in restori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575f84bcfb6720a2db95b45fc7cd6a89
https://doi.org/10.1089/jwh.2009.1378

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trans Fatty acids and systemic inflammation in heart failure

Autor: Wayne C. Levy, George B. McDonald, Irena B. King, Richard L. Lawler, Eric B. Rimm, Dariush Mozaffarian

Publikováno v: The American Journal of Clinical Nutrition. 80:1521-1525

Background: trans Fatty acid (TFA) intake increases systemic inflammation in healthy persons. However, the effect in patients with established heart disease is unknown. Objective: Our aim was to determine whether TFAs are associated with systemic inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e09d437db79c6819bc81b06059e4dd
https://doi.org/10.1093/ajcn/80.6.1521

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Increased tumor necrosis factor-α production after lipopolysaccharide stimulation of whole blood in patients with previous preterm delivery complicated by intra-amniotic infection or inflammation

Autor: Richard L. Lawler, Josephine Amory, David A. Eschenbach, Jane Hitti

Publikováno v: American Journal of Obstetrics and Gynecology. 185:1064-1067

Objective: To compare cytokine production after lipopolysaccharide stimulation of whole blood from women who were delivered of infants at term compared with women who were delivered of preterm infants with intra-amniotic evidence of infection or infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e9a57d7e0a7fd55df25ac205d33154
https://doi.org/10.1067/mob.2001.117637

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Effects of Pregnancy and Bacterial Vaginosis on Proinflammatory Cytokine and Secretory Leukocyte Protease Inhibitor Concentrations in Vaginal Secretions

Autor: Richard L. Lawler, Jane Hitti, Jennifer E. Balkus, Kathy Agnew, Caroline M. Mitchell

Publikováno v: Journal of Pregnancy
Journal of Pregnancy, Vol 2010 (2010)

We compared vaginal proinflammatory cytokine and secretory leukocyte protease inhibitor (SLPI) concentrations among pregnant and nonpregnant women according to bacterial vaginosis (BV) status. One-hundred and twenty-two women at 12–20 weeks' gestat

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