Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Richard L. Klein"'
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 190 (2024)
Abnormalities of sphingolipid metabolism play an important role in diabetes. We compared sphingolipid levels in plasma and in isolated lipoproteins between healthy control subjects and two groups of patients, one with chronic kidney disease without d
Externí odkaz:
https://doaj.org/article/0cb43916372046289d65389cc90da138
Autor:
Arpita Basu, Ionut Bebu, Alicia J. Jenkins, Julie A. Stoner, Ying Zhang, Richard L. Klein, Maria F. Lopes-Virella, W. Timothy Garvey, Matthew J. Budoff, Petar Alaupovic, Timothy J. Lyons
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1432-1439 (2019)
APOB, APOC3, and APOE and apolipoprotein-defined lipoprotein subclasses (ADLSs; based on qualitative apolipoprotein complement) have been associated with dyslipidemia and CVD. Our main objective was to define associations of serum apolipoproteins and
Externí odkaz:
https://doaj.org/article/57fe2509e4d54794a7abcabf30c50e57
Autor:
Arpita Basu, Alicia J. Jenkins, Julie A. Stoner, Ying Zhang, Richard L. Klein, Maria F. Lopes-Virella, W.Timothy Garvey, David S. Schade, Jamie Wood, Petar Alaupovic, Timothy J. Lyons
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 5, Pp 872-883 (2018)
Circulating apolipoprotein-defined lipoprotein subclasses (ADLS) and apolipoproteins predict vascular events in the general and type 2 diabetes populations, but data in T1D are limited. We examined associations of ADLS, serum apolipoproteins, and con
Externí odkaz:
https://doaj.org/article/6cd99c0fd639430884c1020b4f537075
Autor:
Mi-Hye Lee, Kathryn M. Appleton, Hesham M. El-Shewy, Mary G. Sorci-Thomas, Michael J. Thomas, Maria F. Lopes-Virella, Louis M. Luttrell, Samar M. Hammad, Richard L. Klein
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 325-338 (2017)
HDL normally transports about 50–70% of plasma sphingosine 1-phosphate (S1P), and the S1P in HDL reportedly mediates several HDL-associated biological effects and signaling pathways. The HDL receptor, SR-BI, as well as the cell surface receptors fo
Externí odkaz:
https://doaj.org/article/65f47730c6104614afd8fdba1e2a23ef
Autor:
Arpita Basu, Alicia J. Jenkins, Ying Zhang, Julie A. Stoner, Richard L. Klein, Maria F. Lopes-Virella, W. Timothy Garvey, Timothy J. Lyons
Publikováno v:
Data in Brief, Vol 6, Iss , Pp 33-38 (2016)
Type 1 diabetes (T1DM) is associated with increased risk of macrovascular complications. We examined longitudinal associations of serum conventional lipids and nuclear magnetic resonance (NMR)-determined lipoprotein subclasses with carotid intima-med
Externí odkaz:
https://doaj.org/article/53d27bf9a8754d1692511225b6c992b1
Autor:
Ying Zhang, Alicia J. Jenkins, Arpita Basu, Julie A. Stoner, Maria F. Lopes-Virella, Richard L. Klein, Timothy J. Lyons
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 310-317 (2016)
Our objective is to define differences in circulating lipoprotein subclasses between intensive versus conventional management of type 1 diabetes during the randomization phase of the Diabetes Control and Complications Trial (DCCT). NMR-determined lip
Externí odkaz:
https://doaj.org/article/a94d1ccb0a3e48cb8fbe403fb6bd0acd
Autor:
Samar M. Hammad, Waleed O. Twal, Ehtesham Arif, Andrea J. Semler, Richard L. Klein, Deepak Nihalani
Publikováno v:
Genes, Vol 11, Iss 2, p 178 (2020)
Sphingolipids are bioactive lipids associated with cellular membranes and plasma lipoproteins, and their synthesis and degradation are tightly regulated. We have previously determined that low plasma concentrations of certain ceramide species predict
Externí odkaz:
https://doaj.org/article/c25e123759f344a89bc09962f50a9d0d
Autor:
Samar M. Hammad, Jason S. Pierce, Farzan Soodavar, Kent J. Smith, Mohammed M. Al Gadban, Barbara Rembiesa, Richard L. Klein, Yusuf A. Hannun, Jacek Bielawski, Alicja Bielawska
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 10, Pp 3074-3087 (2010)
We used a HPLC-MS/MS methodology for determination of a basic metabolomic profile (18:1,18:0 sphingoid backbone, C14-C26 N-acyl part) of “normal” sphingolipid levels in human serum and plasma. Blood was collected from healthy males and nonpregnan
Externí odkaz:
https://doaj.org/article/de6c5cacb1814381a7e3d6fb199fa18b
Autor:
Mi-Hye Lee, Samar M. Hammad, Andrea J. Semler, Louis M. Luttrell, Maria F. Lopes-Virella, Richard L. Klein
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2619-2628 (2010)
Sphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that regulates numerous key cardiovascular functions. High-density lipoproteins (HDLs) are the major plasma lipoprotein carriers of S1P. Fibrinolysis is a physiological process that allows
Externí odkaz:
https://doaj.org/article/6db450f3253f44d7ad8010ad29b9d204
Autor:
Jonathan W.C. Brock, Alicia J. Jenkins, Timothy J. Lyons, Richard L. Klein, Eunsil Yim, Maria Lopes-Virella, Rickey E. Carter, (DCCT/EDIC) Research Group, Suzanne R. Thorpe, John W. Baynes
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 847-855 (2008)
Cardiovascular disease is a major cause of morbidity and premature mortality in diabetes. HDL plays an important role in limiting vascular damage by removing cholesterol and cholesteryl ester hydroperoxides from oxidized low density lipoprotein and f
Externí odkaz:
https://doaj.org/article/94796c5df90a4b698aef377de2232a2c