Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Richard L. Hurwitz"'
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236175 (2020)
Adenoviruses cause upper respiratory infections, conjunctivitis, keratitis, and gastrointestinal illness. These can be fatal in immunocompromised individuals. Adenoviruses have also been engineered into viral vectors to deliver therapeutic genes or i
Externí odkaz:
https://doaj.org/article/872dac91e60f45cda4d5720598769830
Autor:
Wesley S Bond, Patricia Y Akinfenwa, Laszlo Perlaky, Mary Y Hurwitz, Richard L Hurwitz, Patricia Chévez-Barrios
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e63519 (2013)
Verification that cell lines used for cancer research are derived from malignant cells in primary tumors is imperative to avoid invalidation of study results. Retinoblastoma is a childhood ocular tumor that develops from loss of functional retinoblas
Externí odkaz:
https://doaj.org/article/819d2912a5034febb5732eb36c2c9ce0
Autor:
Bogdan Dinu, Mary Vaughan, Amber M Yates, Russell E. Ware, Precious Uwaezuoke, Richard L. Hurwitz, Norma Estrada, Susan E Kirk, Alaundra Carmouche, Donald H. Mahoney, Gladstone Airewele, Charles G. Minard, Titilope Fasipe, Alex George
Publikováno v:
American journal of hematologyREFERENCES. 95(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87dceb0fbd332061ee68d51a75857f35
https://pubmed.ncbi.nlm.nih.gov/32472611
https://pubmed.ncbi.nlm.nih.gov/32472611
Autor:
Titilope Fasipe, Alaundra Carmouche, Donald H. Mahoney, Mary Vaughan, Kirk E Susan, Alex George, Precious Uwaezuoke, Russell E. Ware, Charles G. Minard, Bogdan Dinu, Amber M Yates, Richard L. Hurwitz, Gladstone Airewele, Norma Estrada
Publikováno v:
Blood. 134:2267-2267
Patients on hydroxyurea who achieve maximum tolerated dose (MTD), defined by a target level of mild myelosuppression, may have greater laboratory and clinical benefits than those maintained on a lower dose. MTD is currently determined by gradual dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f08e1907b85a63000d89de47cdeaafd
https://doi.org/10.1182/blood-2019-127414
https://doi.org/10.1182/blood-2019-127414
Autor:
Zhigang Liu, Xiumei Zhao, Hua Mao, Patricia A. Baxter, Yulun Huang, Litian Yu, Lalita Wadhwa, Jack M. Su, Adekunle Adesina, Lazlo Perlaky, Mary Hurwitz, Neeraja Idamakanti, Seshidhar Reddy Police, Paul L. Hallenbeck, Richard L. Hurwitz, Ching C. Lau, Murali Chintagumpala, Susan M. Blaney, Xiao-Nan Li
Publikováno v:
Neuro-Oncology. 15:1173-1185
Seneca Valley virus (SVV-001) is a nonpathogenic oncolytic virus that can be systemically administered and can pass through the blood-brain barrier. We examined its therapeutic efficacy and the mechanism of tumor cell infection in pediatric malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2024af023052af1946270a5c0a846c
https://doi.org/10.1093/neuonc/not065
https://doi.org/10.1093/neuonc/not065
Publikováno v:
Journal of Biological Chemistry. 287:32697-32707
The success of gene therapy in the ocular environment is partly due to the presence of hyaluronan in vitreous. Here we explore the mechanism of hyaluronan-mediated enhancement of adenoviral vector transgene expression. Introduction of hyaluronan rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff6edcd866a856674a9418ccb5b4c15
https://doi.org/10.1074/jbc.m112.347369
https://doi.org/10.1074/jbc.m112.347369
Autor:
Richard L. Hurwitz, Sharon E. Plon, Patricia Chévez-Barrios, Murali Chintagumpala, Evelyn A. Paysse
Publikováno v:
The Oncologist. 12:1237-1246
The most common ocular cancer in children is retinoblastoma. It affects approximately 300 children in the U.S. every year. It can affect one or both eyes and the disease can be inherited. Altered discoloration of the pupil and strabismus are the usua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dad36dc2608f24b8382d364bf699ca4
https://doi.org/10.1634/theoncologist.12-10-1237
https://doi.org/10.1634/theoncologist.12-10-1237
Autor:
Lalita Wadhwa, Philip Ng, Joshua N. Mallam, Saumya Ray Chaudhuri, Patricia Chévez-Barrios, Richard L. Hurwitz, Mary Y. Hurwitz
Publikováno v:
Molecular Therapy. 15(3):566-570
Adenovirus infection is a significant cause of ocular, respiratory, and gastrointestinal illness and can spread rapidly. Morbidity is considerable in immune-suppressed individuals and there is significant mortality. There are no effective therapies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776043931cf5e18aed673b1fd88963d0
Autor:
Evelyn A. Paysse, Mary Y. Hurwitz, William Mieler, Claudia A. Kozinetz, Murali Chintagumpala, Richard L. Hurwitz, Patricia Chévez-Barrios, Milton Boniuk
Publikováno v:
Journal of Clinical Oncology. 23:7927-7935
Purpose To evaluate the feasibility and safety of adenovirus-mediated gene therapy as a treatment for tumor seeds in the vitreous of children with retinoblastoma. Patients and Methods An Institutional Biosafety Committee–, Institutional Review Boar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6db6036361a280ad07be2ca66e0e18
https://doi.org/10.1200/jco.2004.00.1883
https://doi.org/10.1200/jco.2004.00.1883
Autor:
Murali Chintagumpala, Mary Y. Hurwitz, Patricia Chévez-Barrios, Milton Boniuk, Richard L. Hurwitz
Publikováno v:
Expert Reviews in Molecular Medicine. 5:1-22
Retinoblastoma (Rb) is the most common primary ocular malignancy of children and is caused by a mutation in the gene RB1. Approximately 40% of cases are associated with one or more constitutional mutations, and are therefore heritable, whereas the ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a00f4d7699d09934c789d4c0e1ae28c
https://doi.org/10.1017/s1462399403005520
https://doi.org/10.1017/s1462399403005520