Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Richard L. Horner"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Pharyngeal muscle activity and responsiveness are key pathophysiological traits in human obstructive sleep apnea (OSA) and strong contributors to improvements with pharmacotherapy. The thyrotropin-releasing hormone (TRH) analog taltirelin is
Externí odkaz:
https://doaj.org/article/2a6de399dc3146e7b5508c72b2e38e13
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-25 (2022)
Abstract Successful cholinergic-noradrenergic pharmacotherapy for obstructive sleep apnea (OSA) is thought to be due to effects at the hypoglossal motor nucleus (HMN). Clinical efficacy varies with muscarinic-receptor (MR) subtype affinities. We hypo
Externí odkaz:
https://doaj.org/article/673dde5ff9d74527ae016608e3b3a536
Autor:
Jackie J. Liu, Kevin P. Grace, Richard L. Horner, Miguel A. Cortez, Yiwen Shao, Zhengping Jia
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-11 (2017)
Abstract Human studies demonstrate that sleep impairment is a concurrent comorbidity of autism spectrum disorders (ASD), but its etiology remains largely uncertain. One of the prominent theories of ASD suggests that an imbalance in synaptic excitatio
Externí odkaz:
https://doaj.org/article/98100b93f8a04ed3b75fea77686d172b
Autor:
Jean-Philippe Rousseau, Andreea Furdui, Carolina da Silveira Scarpellini, Richard L. Horner, Gaspard Montandon
Rhythmic breathing is generated by neural circuits located in the brainstem. At its core is the preBötzinger Complex (preBötC), a region of the medulla, necessary for the generation of rhythmic breathing in mammals. The preBötC is comprised of var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ead86208a604e97fe8a2d9bedea021be
https://doi.org/10.1101/2023.01.13.523897
https://doi.org/10.1101/2023.01.13.523897
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 133(5)
One of the major goals for translational sleep science and medicine is to identify viable and tractable pharmacological targets for obstructive sleep apnea and other respiratory disorders of sleep or sedation. In the present preclinical study in rats
Autor:
Kevin P Grace, Richard L Horner
Publikováno v:
Frontiers in Neurology, Vol 6 (2015)
Rapid eye movement (REM) sleep - characterized by vivid dreaming, motor paralysis, and heightened neural activity - is one of the fundamental states of the mammalian central nervous system. Initial theories of rapid eye movement (REM) sleep generatio
Externí odkaz:
https://doaj.org/article/5df98fd2dd554ab8aac36bb7052758c3
Publikováno v:
Neuroscience. 468
Alterations in thalamic GABAergic signaling are implicated in mediating the rise in 12-30 Hz electroencephalogram (EEG) activity that signals anesthetic-induced loss-of-consciousness with GABAA receptor-targeting general anesthetics. A number of mode
Publikováno v:
Sleep
Obstructive sleep apnea (OSA) occurs exclusively during sleep due to reduced tongue motor activity. Withdrawal of excitatory inputs to the hypoglossal motor nucleus (HMN) from wake to sleep contributes to this reduced activity. Several awake–active
Publikováno v:
Sleep
Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus but most brain TRH is located elsewhere where it acts as a neuromodulator. TRH-positive neurons project to the hypoglossal motoneuron pool where TRH receptor RNA shows a high degree
Autor:
Hattie Liu, Richard L. Horner, Jasmin A. Aggarwal, Stuart W. Hughes, Wen-Ying Liu, Gaspard Montandon
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Motoneurons are the final output pathway for the brain’s influence on behavior. Here we identify properties of hypoglossal motor output to the tongue musculature. Tongue motor control is critical to the pathogenesis of obstructive sleep apnea, a co