Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Richard L. Hébert"'
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295284 (2023)
Canagliflozin (CANA) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor with blood glucose lowering effects. CANA also promotes kidney protection in patients with cardiovascular diseases and type 2 diabetes (T2D), as well as in normoglycemic patie
Externí odkaz:
https://doaj.org/article/4c332af801d545ee8e6b7f49680ef27a
Autor:
Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns
Publikováno v:
PLoS ONE, Vol 17, Iss 2 (2022)
Current research on hypertension utilizes more than fifty animal models that rely mainly on stable increases in systolic blood pressure. In experimental hypertension, grading or scoring of glomerulopathy in the majority of studies is based on a wide
Externí odkaz:
https://doaj.org/article/40afb53ba6f94bf39247fe6e8cea6b00
Autor:
Mercedes N. Munkonda, Shareef Akbari, Chloe Landry, Suzy Sun, Fengxia Xiao, Maddison Turner, Chet E. Holterman, Rania Nasrallah, Richard L. Hébert, Christopher R. J. Kennedy, Dylan Burger
Publikováno v:
Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100–1000 nm vesicles shed from injured ce
Externí odkaz:
https://doaj.org/article/aa97d5bb720e4bfb9b20b1ec33f5bd9c
Autor:
Dylan Burger, Christopher R.J. Kennedy, Alex Gutsol, Jean-Francois Thibodeau, Susan J. Robertson, Richard L. Hébert, Jamie Ghossein, Rania Nasrallah, Fengxia Xiao, Kevin D. Burns, Joseph Zimpelmann
Publikováno v:
Laboratory Investigation. 100:414-425
Prostaglandin E2 receptor EP1 (PGE2/EP1) promotes diabetic renal injury, and EP1 receptor deletion improves hyperfiltration, albuminuria, and fibrosis. The role of EP1 receptors in hypertensive kidney disease (HKD) remains controversial. We examined
Autor:
Véronique Cheff, Mayra Trentin-Sonoda, Amélie Blais, Jean-François Thibodeau, Chet E. Holterman, Alex Gutsol, Christopher R. J. Kennedy, Richard L. Hébert
Publikováno v:
PLOS ONE. 18:e0281123
Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dys
Autor:
Alex A. Gutsol, Paula Blanco, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Sergey A. Afanasiev, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert, Kevin D. Burns
Publikováno v:
PloS one. 17(2)
Current research on hypertension utilizes more than fifty animal models that rely mainly on stable increases in systolic blood pressure. In experimental hypertension, grading or scoring of glomerulopathy in the majority of studies is based on a wide
Autor:
Jugurtha Ouboudinar, Ramon Corpuz, Martin Leduc, Jean-Simon Duceppe, Alexandre Laverdure, Mikaël Tremblay, Kathy Hince, Amélie Blais, Marie-Pier Cloutier, Richard L. Hébert, Christopher R.J. Kennedy, Alexandra Blais, Liette Gervais, Lilianne Geerts, Lyne Gagnon, Pierre Laurin, Jean-Christophe Simard, Steven R. LaPlante, Sylvie Létourneau, Jean-Francois Thibodeau, François A. Leblond, Brigitte Grouix, Shaun D. Abbott, Boulos Zacharie, Alexandra Felton, Vanessa Marques Quintela, William Gagnon, François Sarra-Bournet
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and is associated with metabolic dysregulation. Although G protein-coupled receptor 84 (GPR84) has been associated with inflammation, its role in metabolic regulation
Autor:
Chet E. Holterman, Jean-Francois Thibodeau, Amélie Blais, Richard L. Hébert, Véronique Cheff, Chris R. J. Kennedy
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Fatty acid receptors have recently been implicated in the progression of fibrotic disorders. GPR40 deletion predisposes to AKI and CKD-induced fibrosis, while deletion of the pro-inflammatory GPR84 receptor was beneficial in this
Autor:
Jean-Francois Thibodeau, Alexandre Laverdure, Kathy Hince, Richard L. Hébert, Alex Gutsol, William Gagnon, Martin Leduc, Eldjonai Kamto, Liette Gervais, Shaun D. Abbott, Christopher R.J. Kennedy, Francois A. Leblond, Jonathan Richard, Pierre Laurin, Chet E. Holterman, Alexandra Felton, Ming-Zhi Zhang, François Sarra-Bournet, Mikaël Tremblay, Jugurtha Ouboudinar, Lilianne Geerts, Christopher Penney, Lyne Gagnon, Jocelyn Dupuis, Jean-Christophe Simard, Jean-Simon Duceppe, Quang Trinh Nguyen, Marie-Pier Cloutier, Raymond C. Harris, Angelino Calderone, Brigitte Grouix, Boulos Zacharie, Sylvie Létourneau
Publikováno v:
The American Journal of Pathology. 188:1132-1148
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein–coupled receptors with
Publikováno v:
PPAR Research, Vol 2009 (2009)
The collecting duct (CD) expresses considerable amounts of PPARδ. While its role is unknown in the CD, in other renal cells it has been shown to regulate both growth and apoptosis. We thus hypothesized that PPARδ reduces apoptotic responses and sti
Externí odkaz:
https://doaj.org/article/14aacc95fa6e4bd99ceba41fb418a9ca