Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Richard L. Gieseck"'
Autor:
Shuxi Qiao, Brianna LaViolette, Brianna LaCarubba Paulhus, Xiangping Li, John Litchfield, Zhenhong Li, John C. Stansfield, Richard L. Gieseck III, Bei B. Zhang, Danna M. Breen
Publikováno v:
JCSM Rapid Communications, Vol 6, Iss 2, Pp 122-133 (2023)
Abstract Background Inflammation is a hallmark of cachexia; however, effective anti‐inflammatory treatments have not yet been identified. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a key signalling node linking interleukin‐1 recept
Externí odkaz:
https://doaj.org/article/e431d4d801b04a6dae39ebe825e67012
Autor:
Thiago A. Pereira, Richard L. Gieseck, Marion T. Kasaian, Trisha S. Pasricha, Fang Jin, Lioudmila Tchistiakova, Farmer Mark A, Robert W. Thompson, Kayla J. Knilans, Nan Bing, Thomas A. Wynn, Rafael de Queiroz Prado, Kevin M. Vannella, Aaron Kleinman, Thirumalai R. Ramalingam, Martin Hegen, David A. Hinds, Erik P. Karmele
Publikováno v:
Mucosal immunology
There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we foun
Autor:
Richard L Gieseck, Nicholas R F Hannan, Roque Bort, Neil A Hanley, Rosemary A L Drake, Grant W W Cameron, Thomas A Wynn, Ludovic Vallier
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86372 (2014)
Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce the demand for a dwindling number of primary cells used in applications ranging from therapeutic cell infusions to in vitro toxicology studies. However, curren
Externí odkaz:
https://doaj.org/article/9f6b9f4dd535417faa7c438470c69ea3
Autor:
Peter Caravan, Diego dos Santos Ferreira, Nicholas J. Rotile, Richard L. Gieseck, Kenneth K. Tanabe, Gunisha Arora, Thomas A. Wynn, Bryan C. Fuchs, Philip A. Waghorn
Publikováno v:
Invest Radiol
RATIONALE AND OBJECTIVES: Fibrosis is characterized by progressive replacement of normal tissue by extracellular matrix. Diagnosis relies on biopsies as noninvasive methods for detection and quantification of fibrosis are still limited. This work aim
Publikováno v:
Comp Med
An increased incidence of dilated cardiomyopathy and atrial thrombosis was noted in a breeding colony of BALB/c mice deficient in IL4 receptor α. The condition affected mice of both sexes and of various ages, and extensive testing (microbiology, ser
Autor:
Matthias Zilbauer, Olivia C. Tysoe, Daniele Muraro, Ludovic Vallier, Carola M. Morell, Nicholas R.F. Hannan, Stuart J. Forbes, Samantha G. Tilson, Richard L. Gieseck, Thomas A. Wynn, Simone E. Adams, Rute A. Tomaz, Brandon T Wesley, Wei-Yu Lu, Judith Kraiczy, John R. Ferdinand, Kourosh Saeb-Parsy, Gabriel C. Oniscu, Alexander Ross, Casey A. Rimland, Francisco Otaizo-Carrasquero, Nikitas Georgakopoulos, Timothy G. Myers, Fotios Sampaziotis
Publikováno v:
Hepatology
Rimland, C A, Tilson, S G, Morell, C M, Tomaz, R A, Lu, W-Y, Adams, S E, Georgakopoulos, N, Otaizo-Carrasquero, F, Myers, T G, Ferdinand, J R, Gieseck, R L, Sampaziotis, F, Tysoe, O C, Wesley, B, Muraro, D, Oniscu, G C, Hannan, N R, Forbes, S J, Saeb-Parsy, K, Wynn, T A & Vallier, L 2020, ' Regional differences in human biliary tissues and corresponding in vitro derived organoids ', Hepatology . https://doi.org/10.1002/hep.31252
Hepatology (Baltimore, Md.)
Rimland, C A, Tilson, S G, Morell, C M, Tomaz, R A, Lu, W-Y, Adams, S E, Georgakopoulos, N, Otaizo-Carrasquero, F, Myers, T G, Ferdinand, J R, Gieseck, R L, Sampaziotis, F, Tysoe, O C, Wesley, B, Muraro, D, Oniscu, G C, Hannan, N R, Forbes, S J, Saeb-Parsy, K, Wynn, T A & Vallier, L 2020, ' Regional differences in human biliary tissues and corresponding in vitro derived organoids ', Hepatology . https://doi.org/10.1002/hep.31252
Hepatology (Baltimore, Md.)
Background and aims Organoids provide a powerful system to study epithelia in vitro. Recently, this approach was applied successfully to the biliary tree, a series of ductular tissues responsible for the drainage of bile and pancreatic secretions. Mo
Autor:
Sanjay Sinha, Victoria L. Mulcahy, William Gelson, Kourosh Saeb-Parsy, Brandon T Wesley, Sarah A. Teichmann, Laure Gambardella, Timothy E. Beach, Sharayne Robinson, Michael P. Murphy, Paul Gibbs, Stephanie Brown, Richard L. Gieseck, Peter C. Humphreys, Corrina Fear, Anna Osnato, Krishnaa T. Mahbubani, Gareth Corbett, Irum Amin, Olivia C. Tysoe, Daniele Muraro, Christopher J.E. Watson, Espen Melum, Daniel Ortmann, Andrew J. Butler, George F. Mells, Teresa Brevini, Keziah Crick, Sara Upponi, Fotios Sampaziotis, Susan E. Davies, Teik Choon See, Giovanni Canu, Stephen J. Sawiak, Jose Garcia-Bernardo, Edmund Godfrey, Ludovic Vallier, N.L. Berntsen, Lisa Swift, Johannes Bargehr
Publikováno v:
Science (New York, N.Y.). 371(6531)
Organoids regenerate human bile ducts Bile ducts carry bile from the liver and gall bladder to the small intestine, where it aids digestion. Cholangiocytes are epithelial cells that line bile ducts and modify bile as its transported through the bilia
Publikováno v:
Nature Reviews Immunology. 18:62-76
Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this immune response is commonly observed in tissues during allergic inflammation or infection with helminth parasites. However, many of the key cell types associat
Autor:
Richard L. Gieseck, Thomas H. Acciani, Allen W. Cheever, Thirumalai R. Ramalingam, Thomas A. Wynn, Kevin M. Vannella, Kevin M. Hart, Margaret M. Mentink-Kane
Publikováno v:
The Journal of Pathology. 239:344-354
Persistent or dysregulated IL-13 responses are key drivers of fibrosis in multiple organ systems, and this identifies this cytokine as an important therapeutic target. Nevertheless, the mechanisms by which IL-13 blockade leads to the amelioration of
Autor:
Neil C. Henderson, Joshua Sciurba, Kevin M. Vannella, Nikhil Jiwrajka, Erik P. Karmele, Kevin M. Hart, Sandra White, Jamie L Redes, Thomas A. Wynn, Richard L. Gieseck
Publikováno v:
Sciurba, J C, Gieseck, R L, Jiwrajka, N, White, S D, Karmele, E P, Redes, J, Vannella, K M, Henderson, N C, Wynn, T A & Hart, K M 2018, ' Fibroblast-specific integrin alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis ', The Journal of Pathology . https://doi.org/10.1002/path.5215
Fibroproliferative diseases affect a significant proportion of the world's population. Despite this, core mechanisms driving organ fibrosis of diverse etiologies remain ill defined. Recent studies suggest that integrin-alpha V serves as a master driv